- Metformin Ameliorates Lipotoxic β-Cell Dysfunction through a Concentration-Dependent Dual Mechanism of Action
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Kim HI, Lee JS, Kwak BK, Hwang WM, Kim MJ, Kim YB, Chung SS, Park KS
- KMID: 2466506
- Diabetes Metab J.
- 2019 Dec;43(6):854-866.
- doi: 10.4093/dmj.2018.0179
BACKGROUND: Chronic exposure to elevated levels of free fatty acids contributes to pancreatic β-cell dysfunction. Although it is well known that metformin induces cellular energy depletion and a concomitant activation... -
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- Effect of Ambrisentan Therapy on the Expression of Endothelin Receptor, Endothelial Nitric Oxide Synthase and NADPH Oxidase 4 in Monocrotaline-induced Pulmonary Arterial Hypertension Rat Model
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Lee H, Yeom A, Kim KC, Hong YM
- KMID: 2455794
- Korean Circ J.
- 2019 Sep;49(9):866-876.
- doi: 10.4070/kcj.2019.0006
BACKGROUND AND OBJECTIVES: Elevated endothelin (ET)-1 level is strongly correlated with the pathogenesis of pulmonary arterial hypertension (PAH). Expression level of nicotinamide adenine dinucleotide phosphate oxidase (NOX) 4 is increased... -
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- Efficacy of Diphenyleneiodonium Chloride (DPIC) Against Diverse Plant Pathogens
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Jung B, Li T, Ji S, Lee J
- KMID: 2455605
- Mycobiology.
- 2019 Mar;47(1):105-111.
- doi: 10.1080/12298093.2018.1559122
Many of the fungicides and antibiotics currently available against plant pathogens are of limited use due to the emergence of resistant strains. In this study, we examined the effects of... -
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- Perivascular Cells and NADPH Oxidase Inhibition Partially Restore Hyperglycemia-Induced Alterations in Hematopoietic Stem Cell and Myeloid-Derived Suppressor Cell Populations in the Bone Marrow
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Kim JY, Lee JY, Ha KS, Han ET, Park WS, Min CK, Hong SH
- KMID: 2447225
- Int J Stem Cells.
- 2019 Mar;12(1):63-72.
- doi: 10.15283/ijsc18097
BACKGROUND AND OBJECTIVES: Patients suffer from long-term diabetes can result in severe complications in multiple organs through induction of vascular dysfunctions. However, the effects of chronic hyperglycemic conditions on hematopoiesis... -
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- Selective inhibition of histone deacetylase 8 improves vascular hypertrophy, relaxation, and inflammation in angiotensin II hypertensive mice
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Kee HJ, Ryu Y, Seok YM, Choi SY, Sun S, Kim GR, Jeong MH
- KMID: 2468620
- Clin Hypertens.
- 2019 ;25(1):13.
- doi: 10.1186/s40885-019-0118-8
BACKGROUND: The dysregulation of histone deacetylase (HDAC) protein expression or its enzyme activity is implicated in a variety of diseases. Cardiac HDAC6 and HDAC8 enzyme activity induced by deoxycorticosterone acetate... -
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- Change of voltage-gated potassium channel 1.7 expressions in monocrotaline-induced pulmonary arterial hypertension rat model
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Lee H, Kim KC, Hong YM
- KMID: 2422365
- Korean J Pediatr.
- 2018 Sep;61(9):271-278.
- doi: 10.3345/kjp.2018.06457
PURPOSE: Abnormal potassium channels expression affects vessel function, including vascular tone and proliferation rate. Diverse potassium channels, including voltage-gated potassium (Kv) channels, are involved in pathological changes of pulmonary arterial... -
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- Effects of NADPH Oxidase Inhibitors and Mitochondria-Targeted Antioxidants on Amyloid βâ‚â‚‹â‚„â‚‚-Induced Neuronal Deaths in Mouse Mixed Cortical Cultures
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Hwang S, Kim JK
- KMID: 2420883
- Chonnam Med J.
- 2018 Sep;54(3):159-166.
- doi: 10.4068/cmj.2018.54.3.159
The Amyloid β peptide (Aβ) is a main component of senile plaques in Alzheimer's disease. Currently, NADPH oxidase (NOX) and mitochondria are considered as primary sources of ROS induced by... -
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- Arginase Inhibition Suppresses Native Low-Density Lipoprotein-Stimulated Vascular Smooth Muscle Cell Proliferation by NADPH Oxidase Inactivation
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Koo BH, Yi BG, Wang WK, Ko IY, Hoe KL, Kwon YG, Won MH, Kim YM, Lim HK, Ryoo S
- KMID: 2407859
- Yonsei Med J.
- 2018 May;59(3):366-375.
- doi: 10.3349/ymj.2018.59.3.366
PURPOSE: Vascular smooth muscle cell (VSMC) proliferation induced by native low-density lipoprotein (nLDL) stimulation is dependent on superoxide production from activated NADPH oxidase. The present study aimed to investigate whether... -
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- YJI-7 Suppresses ROS Production and Expression of Inflammatory Mediators via Modulation of p38MAPK and JNK Signaling in RAW 264.7 Macrophages
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Oh HJ, Magar TB, Pun NT, Lee Y, Kim EH, Lee ES, Park PH
- KMID: 2429059
- Biomol Ther.
- 2018 Mar;26(2):191-200.
- doi: 10.4062/biomolther.2016.276
Chalcone, (2E)-1,3-Diphenylprop-2-en-1-one, and its synthetic derivatives are known to possess anti-oxidative and anti-inflammatory properties. In the present study, we prepared a novel synthetic chalcone compound, (E)-1-(4-hydroxyphenyl)-3-(2-(trifluoromethoxy)phenyl)prop-2-en-1-one name (YJI-7), and investigated... -
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- Correlation between NADPH oxidase-mediated oxidative stress and dysfunction of endothelial progenitor cell in hyperlipidemic patients
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Li TB, Zhang YZ, Liu WQ, Zhang JJ, Peng J, Luo XJ, Ma QL
- KMID: 2411543
- Korean J Intern Med.
- 2018 Mar;33(2):313-322.
- doi: 10.3904/kjim.2016.140
BACKGROUND/AIMS: NADPH (nicotinamide adenine dinucleotide phosphate) oxidase (NOX)-mediated oxidative stress plays a key role in promotion of oxidative injury in the cardiovascular system. The aim of this study is to... -
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- Lignans with NADPH Oxidase 2 (NOX2)-inhibitory Activity from the Fruits of Schisandra chinensis
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Park JM, Pel P, Chin YW, Lee MY
- KMID: 2409611
- Nat Prod Sci.
- 2018 Mar;24(1):59-65.
- doi: 10.20307/nps.2018.24.1.59
An isoform of NADPH oxidase (NOX), NOX2 is a superoxide-generating enzyme involved in diverse pathophysiological events. Although its potential as a therapeutic target has been validated, there is no clinically... -
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- Biphasic augmentation of alpha-adrenergic contraction by plumbagin in rat systemic arteries
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Kim HJ, Yoo HY, Zhang YH, Kim WK, Kim SJ
- KMID: 2395264
- Korean J Physiol Pharmacol.
- 2017 Nov;21(6):687-694.
- doi: 10.4196/kjpp.2017.21.6.687
Plumbagin, a hydroxy 1,4-naphthoquinone compound from plant metabolites, exhibits anticancer, antibacterial, and antifungal activities via modulating various signaling molecules. However, its effects on vascular functions are rarely studied except in... -
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- NADPH Oxidase Mediates β-Amyloid Peptide-Induced Neuronal Death in Mouse Cortical Cultures
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Chay KO, Nam Koong , Hwang S, Kim JK, Bae CS
- KMID: 2390433
- Chonnam Med J.
- 2017 Sep;53(3):196-202.
- doi: 10.4068/cmj.2017.53.3.196
β-Amyloid peptide (Aβ) is the main component of senile plaques in patients with Alzheimer's disease, and is known to be a main pathogenic factor of the disease. Recent evidence indicates... -
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- NOX Inhibitors - A Promising Avenue for Ischemic Stroke
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Kim JY, Park J, Lee JE, Yenari MA
- KMID: 2389006
- Exp Neurobiol.
- 2017 Aug;26(4):195-205.
- doi: 10.5607/en.2017.26.4.195
NADPH-oxidase (NOX) mediated superoxide originally found on leukocytes, but now recognized in several types of cells in the brain. It has been shown to play an important role in the... -
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- Compound Heterozygous Mutations in the DUOX2/DUOXA2 Genes Cause Congenital Hypothyroidism
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Zheng X, Ma SG, Guo ML, Qiu YL, Yang LX
- KMID: 2419100
- Yonsei Med J.
- 2017 Jul;58(4):888-890.
- doi: 10.3349/ymj.2017.58.4.888
The mutations in the dual oxidase 2 (DUOX2) and dual oxidase maturation factor 2 (DUOXA2) genes can cause congenital hypothyroidism (CH). This study reports the pedigree with goitrous congenital hypothyroidism... -
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- 4-O-Methylhonokiol Protects HaCaT Cells from TGF-β1-Induced Cell Cycle Arrest by Regulating Canonical and Non-Canonical Pathways of TGF-β Signaling
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Kim SC, Kang JI, Hyun JW, Kang JH, Koh YS, Kim YH, Kim KH, Ko JH, Yoo ES, Kang HK
- KMID: 2386909
- Biomol Ther.
- 2017 Jul;25(4):417-426.
- doi: 10.4062/biomolther.2016.003
4-O-methylhonokiol, a neolignan compound from Magnolia Officinalis, has been reported to have various biological activities including hair growth promoting effect. However, although transforming growth factor-β (TGF-β) signal pathway has an... -
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- Inhibitors of DNA methylation support TGF-β1-induced IL11 expression in gingival fibroblasts
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Sufaru IG, Beikircher G, Weinhaeusel A, Gruber R
- KMID: 2377741
- J Periodontal Implant Sci.
- 2017 Apr;47(2):66-76.
- doi: 10.5051/jpis.2017.47.2.66
PURPOSE: Oral wound healing requires gingival fibroblasts to respond to local growth factors. Epigenetic silencing through DNA methylation can potentially decrease the responsiveness of gingival fibroblasts to local growth factors.... -
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- Capsaicin prevents degeneration of dopamine neurons by inhibiting glial activation and oxidative stress in the MPTP model of Parkinson's disease
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Chung YC, Baek JY, Kim SR, Ko HW, Bok E, Shin WH, Won SY, Jin BK
- KMID: 2375785
- Exp Mol Med.
- 2017 Mar;49(3):e298.
- doi: 10.1038/emm.2016.159
The effects of capsaicin (CAP), a transient receptor potential vanilloid subtype 1 (TRPV1) agonist, were determined on nigrostriatal dopamine (DA) neurons in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse model of Parkinson's disease... -
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- Roles of Reactive Oxygen Species in Rheumatoid Arthritis Pathogenesis
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Yoo SJ, Go E, Kim YE, Lee S, Kwon J
- KMID: 2364687
- J Rheum Dis.
- 2016 Dec;23(6):340-347.
- doi: 10.4078/jrd.2016.23.6.340
Rheumatoid arthritis (RA) is an autoimmune disease that starts with decreased tolerance to modified self-antigens and eventually leads to synovitis and destruction of bone and cartilage. Age is a risk... -
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- NADPH Oxidase 1 and NADPH Oxidase 4 Have Opposite Prognostic Effects for Patients with Hepatocellular Carcinoma after Hepatectomy
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Ha SY, Paik YH, Yang JW, Lee MJ, Bae H, Park CK
- KMID: 2412082
- Gut Liver.
- 2016 Sep;10(5):826-835.
- doi: 10.5009/gnl15543
BACKGROUND/AIMS: Nicotinamide adenine dinucleotide phosphate oxidase (NOX)-mediated reactive oxygen species contribute to various liver diseases, including hepatocellular carcinoma (HCC). Uncertainties remain regarding the prognostic relevance of NOX1 and NOX4 protein... -
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