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Successful long-term management of late-stage precursor-targeted immune-mediated anemia with prednisolone and mycophenolate mofetil in a dog

Kim D, Song WJ, Kim SS, Jeong S, Hong HJ, Yun Y

A 13-year-old neutered male Maltese dog presented to our hospital with lethargy and anorexia. Laboratory abnormalities included severe non-regenerative anemia (hematocrit, 12.9%; reticulocyte count 12.8 K/μL). The cytology of bone...
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A multicenter, randomized, open-label, comparative, phase IV study to evaluate the efficacy and safety of combined treatment with mycophenolate mofetil and corticosteroids in advanced immunoglobulin A nephropathy

Han SY, Jung CY, Lee SH, Lee DW, Lee S, Kim CD, Choi BS, Kim BS

Background: It remains unclear whether immunosuppressive agents are effective in patients with immunoglobulin A nephropathy (IgAN). We investigated the efficacy of a mycophenolate mofetil (MMF) and corticosteroid combination therapy in...
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The Efficacy of Mycophenolate Mofetil in Remission Maintenance Therapy for Microscopic Polyangiitis and Granulomatosis with Polyangiitis

Pyo JY, Lee LE, Ahn SS, Song JJ, Park YB, Lee SW

Purpose: The present study compared the efficacy of mycophenolate mofetil (MMF) with that of azathioprine (AZA) in Korean patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA). Materials and Methods:...
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The impact of omeprazole on mycophenolate pharmacokinetics in kidney transplant recipients

AbdElhalim MS, Kenawy AS, El Demellawy HH, Azouz AA, Alghanem SS, Al-Otaibi T, Gheith O, ElMonem MA, Afifi MK, Hussein RRS

Background: The absorption rates of mycophenolate mofetil (MMF) and enteric-coated mycophenolate sodium (EC- MPS) may be influenced by the concomitant use of omeprazole. Methods: One hundred kidney transplant patients were recruited during...
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Cross-sectional analysis of immunosuppressive regimens focused on everolimus after liver transplantation in a Korean high-volume transplantation center

Kang SH, Hwang S, Ha TY, Song GW, Jung DH, Ahn CS, Moon DB, Kim KH, Park GC, Yoon YI, Park YH, Cho HD, Kwon JH, Chung YK, Choi JU, Lee SG

BACKGROUND: The mammalian target of the rapamycin inhibitor has dual inhibitory effects on cell growth and angiogenesis. This study aimed to analyze the usage of everolimus on actual immunosuppression (IS)...
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The Effect of Mycophenolate Mofetil on Non-Renal Manifestations in Systemic Lupus Erythematosus: Results from Korean Lupus Network Registry

Jung UH, Kwak SG, Choe JY, Lee SS, Kim SK

BACKGROUND: The objective of this study was to identify the effects of mycophenolate mofetil (MMF) on non-renal manifestations in systemic lupus erythematosus (SLE). METHODS: The study population comprised 439 SLE patients...
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A cross-sectional analysis of long-term immunosuppressive regimens after liver transplantation at Asan Medical Center: Increased preference for mycophenolate mofetil

Hwang S, Ahn CS, Kim KH, Moon DB, Ha TY, Song GW, Jung DH, Park GC, Lee SG

BACKGROUNDS/AIMS: Long-term immunosuppression regimens after liver transplantation (LT) are rarely reported in detail. We aimed to provide information on actual long-term immunosuppression regimens through this cross-sectional study. METHODS: Our institutional LT...
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The Effect of Mycophenolate Mofetil versus Cyclosporine as Combination Therapy with Low Dose Corticosteroids in High-risk Patients with Idiopathic Membranous Nephropathy: a Multicenter Randomized Trial

Choi JY, Kim DK, Kim YW, Yoo TH, Lee JP, Chung HC, Cho KH, An WS, Lee DH, Jung HY, Cho JH, Kim CD, Kim YL, Park SH

BACKGROUND: Appropriate immunosuppressive therapy for patients with idiopathic membranous nephropathy (MN) remains controversial. The effect of mycophenolate mofetil (MMF) versus cyclosporine (CsA) combined with low-dose corticosteroids was evaluated in patients...
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The use of immunosuppression in autoimmune hepatitis: A current literature review

Cropley A, Weltman M

Autoimmune hepatitis (AIH) is an organ specific autoimmune condition which can manifest at any age of life. The heterogeneous nature of this condition means that great variation can be seen...
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Intra-individual variability of mycophenolic acid concentration according to renal function in liver transplant recipients receiving mycophenolate monotherapy

Hwang S, Song GW, Jung DH, Park GC, Ahn CS, Moon DB, Ha TY, Kim KH, Lee SG

BACKGROUNDS/AIMS: Mycophenolate mofetil (MMF) has wide inter- and intra-individual variability of mycophenolic acid (MPA) after liver transplantation (LT). On this study, we aimed to analyse the intra-individual variability of MPA...
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Mycophenolate mofetil as an alternative treatment for autoimmune hepatitis

Park SW, Um SH, Lee HA, Kim SH, Sim Y, Yim SY, Seo YS, Ryu HS

Autoimmune hepatitis (AIH) is an immune-mediated chronic liver disease characterized by hepatocellular inflammation, necrosis, and fibrosis, which can progress to cirrhosis and fulminant hepatic failure. The standard treatment for AIH...
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Mycophenolate Mofetil for Chronic Uveitis in Koreans

Ahn MW, Kim HW, Lee JE

PURPOSE: To evaluate the therapeutic effect and safety of mycophenolate mofetil (MMF) on chronic uveitis in Korean patients. METHODS: This study included 25 patients with chronic uveitis who used MMF and...
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Mycophenolate Mofetil for Treatment of Autoimmune Hemolytic Anemia and Nephrotic Syndrome after Cord Blood Transplantation

Lee JM, Kim SY, Kim YK

We report on a 2-year-old girl who developed autoimmune hemolytic anemia, which occurred with minimal change nephrotic syndrome 3 months after umbilical cord blood transplantation for acute megakaryocytic leukemia. Because...
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A multicenter experience with generic mycophenolate mofetil conversion in stable liver transplant recipients

Kim JM, Kwon CH, Yun IJ, Lee KW, Yu HC, Suh KS, Joh JW, Cho BH

PURPOSE: Generic substitution of brand-name medications can lead to significant cost savings and is an accepted medical practice. This study evaluated clinical and safety outcomes among liver transplant recipients whose...
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Application of mycophenolate mofetil for immune-mediated hemolytic anemia in two dogs

Park HJ, Lee DY, Song KH

  • KMID: 1435836
  • Korean J Vet Res.
  • 2012 Sep;52(3):209-211.
A 5-year-old castrated male Shih-tzu dog and a 9-year-old intact female Schnauzer dog were presented with anorexia and depression. These 2 dogs were diagnosed based on which criteria as primary...
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Increased Incidence of Endoscopic Erosive Esophagitis in Solid Organ Transplant Recipients

Kim IS, Lee H, Park JC, Shin SK, Lee SK, Lee YC

  • KMID: 2053498
  • Gut Liver.
  • 2012 Jul;6(3):349-354.
BACKGROUND/AIMS: Solid organ transplant recipients frequently report gastrointestinal symptoms, especially heartburn or dyspepsia. However, the prevalence of endoscopic erosive esophagitis (EE) and associated risk factors after transplantation are unknown. The...
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Prospective Controlled Protocol for Three Months Steroid Withdrawal with Tacrolimus, Basiliximab, and Mycophenolate Mofetil in Renal Transplant Recipients

Oh CK, Kim SJ, Kim JH, Lee JH

During the past few years, new immunosuppressants, such as tacrolimus, mycophenolate mofetil (MMF) and basiliximab, have been shown to successfully decrease the incidence of acute rejection, possibly acting as potent...
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A Case of Minimal Change Disease Treated Successfully with Mycophenolate Mofetil in a Patient with Systemic Lupus Erythematosus

Hong YH, Yun DY, Jung YW, Oh MJ, Kim HJ, Lee CK

The World Health Organization classifies lupus nephritis as class I to V or VI. However, a few cases of minimal change glomerulopathy have been reported in association with systemic lupus...
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Oral Ulceration an Overlooked Complication of Mycophenolate Mofetil in a Renal Transplant Recipient

Ahn SH, Min SK, Min SI, Kim SY, Kim SJ, Ha J

  • KMID: 2324204
  • J Korean Soc Transplant.
  • 2011 Jun;25(2):113-115.
Mycophenolate mofetil (MMF) is being widely used as a maintenance imunosuppressive therapy in renal transplant patients. Myelotoxicity and gastrointestinal symptoms are the well-known adverse effects of this immunosuppressant. However, there...
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Improved Gastrointestinal Symptoms and Quality of Life after Conversion from Mycophenolate Mofetil to Enteric-Coated Mycophenolate Sodium in Renal Transplant Patients Receiving Tacrolimus

Hwang HS, Hyoung BJ, Kim S, Oh HY, Kim YS, Kim JK, Kim YH, Kim YL, Kim CD, Shin GT, Yang CW

It is reported that a conversion from mycophenolate mofetil (MMF) to enteric-coated mycophenolate sodium (EC-MPS) relieves gastrointestinal (GI) symptom burden and improves health-related quality of life (HRQoL). However, it is...
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