- Asp 280 residue is important in the activity of the Escherichia coli leader peptidase
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Sung MS, Park KS
- KMID: 1029933
- Exp Mol Med.
- 1999 Jun;31(2):64-69.
Leader peptidase is a novel serine protease in Escherichia coli, which catalyzes the cleavage of amino-terminal signal sequences from exported proteins. It is an integral membrane protein containing two transmembrane segments with... -
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- Functional Role of Serine Residues of Transmembrane Dopamin VII in Signal Transduction of CB2 Cannabinoid Receptor
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Rhee MH
- KMID: 1095120
- J Vet Sci.
- 2002 Sep;3(3):185-191.
Using site-directed mutagenesis technique, I have replaced serine 285 and serine 292 with the alanine, and assessed the binding of agonist and signaling such as the inhibition of adenylyl cyclase... -
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- Homo-dimerization of RyR1 C-terminus via charged residues in random coils or in an alpha-helix
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Lee EH, Allen PD
- KMID: 1090962
- Exp Mol Med.
- 2007 Oct;39(5):594-602.
To investigate the mechanism by which the C-terminus (4,938-5,037) of the ryanodine receptor 1 (RyR1) homo-tetramerizes, forming a functional Ca2+ -release channel, the structural requirements for the tetramerization were studied... -
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- Expression and Characterization of the Human Immunodeficiency Virus Type 1 Mutant Envelope Glycoproteins in Mammalian Cells
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Ryu JY, Park JS
- KMID: 1544250
- J Korean Soc Virol.
- 1999 Sep;29(3):183-193.
Human immunodeficiency virus type 1(HIV-1) envelope glycoprotein is synthesized as a 160KDa precursor, gp160, that is cleaved by a cellular protease to form the gp120 and gp41 subunits. Mammalian expression... -
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- Site-Specific Mutagenesis in Human Cells by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives
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Moon KY
- KMID: 2127916
- Cancer Res Treat.
- 2004 Apr;36(2):151-156.
PURPOSE: 7-Bromomethylbenz[a]anthracene is a well- known mutagen and carcinogen. The aim of this study is to determine the mutagenic potency of its two major DNA adducts [N2-(benz[a]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[a]a2G) and N6-(benz[a]anthracen-7-... -
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- Intrinsic Gating in Inward Rectifier Potassium Channels (Kir2.1) with Low Polyamine Affinity Generated by Site Directed Mutagenesis
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So I, Ashmole I, Soh H, Park C, Spencer P, Leyland M, Stanfield
- KMID: 2071587
- Korean J Physiol Pharmacol.
- 2003 Jun;7(3):131-142.
We have studied mutant forms of Kir2.1 in which an aspartate residue (D172), important for gating by intracellular polyamines, is replaced by one of three basic residues (Arg, Lys or... -
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- Ahcyl2 upregulates NBCe1-B via multiple serine residues of the PEST domain-mediated association
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Park PW, Ahn JY, Yang D
- KMID: 2371061
- Korean J Physiol Pharmacol.
- 2016 Jul;20(4):433-440.
- doi: 10.4196/kjpp.2016.20.4.433
Inositol-1,4,5-triphosphate [IP3] receptors binding protein released with IP3 (IRBIT) was previously reported as an activator of NBCe1-B. Recent studies have characterized IRBIT homologue S-Adenosylhomocysteine hydrolase-like 2 (AHCYL2). AHCYL2 is highly... -
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- Functional identification of protein phosphatase 1-binding consensus residues in NBCe1-B
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Lee KP, Kim HJ, Yang D
- KMID: 2398559
- Korean J Physiol Pharmacol.
- 2018 Jan;22(1):91-99.
- doi: 10.4196/kjpp.2018.22.1.91
Protein phosphatase 1 (PP1) is involved in various signal transduction mechanisms as an extensive regulator. The PP1 catalytic subunit (PP1c) recognizes and binds to PP1-binding consensus residues (FxxR/KxR/K) in NBCe1-B.... -
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- Site-Specific Mutagenesis in Escherichia coli by Bulky Exocyclic Amino-Substituted Guanine and Adenine Derivatives in Double-Stranded or Gapped Plasmids
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Moon KY
- KMID: 1807225
- Cancer Res Treat.
- 2003 Feb;35(1):75-80.
PURPOSE: 7-Bromomethylbenz[alpha]anthracene is a known mutagen and carcinogen. The mutagenic potency of its two major DNA adducts, i.e., N2-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyguanosine (b[alpha]a2G) and N6-(benz[alpha]anthracen-7-ylmethyl)-2'-deoxyadenosine (b[alpha]a6A), as well as the simpler benzylated analogs,... -
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- Search for "Proximal Histidine" of Thyroperoxidase Using Site Directed Mutagenesis
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Kim WB, Shong YK
- KMID: 2200381
- J Korean Soc Endocrinol.
- 2003 Aug;18(4):371-378.
BACKGROUND: Thyroperoxidase (TPO), a transmembrane heme containing glycoprotein, catalyzes iodide organification and thyroid hormone synthesis. It is a single peptide making a loop with more than one disulfide bond. The... -
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- An antibody reactive to the Gly63-Lys68 epitope of NT-proBNP exhibits O-glycosylation-independent binding
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Lee Y, Kim H, Chung J
- KMID: 2155379
- Exp Mol Med.
- 2014 Sep;46(9):e114.
- doi: 10.1038/emm.2014.57
The N-terminal fragment of prohormone brain natriuretic peptide (NT-proBNP) is a commonly used biomarker for the diagnosis of congestive heart failure, although its biological function is not well known. NT-proBNP... -
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- Volatile General Anesthetics and Tandem Pore Domain K+ Channel
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Shin WJ
- KMID: 1482465
- Hanyang Med Rev.
- 2008 Nov;28(4):63-72.
Two-pore domain K+ (K2P) channels are recently described. They have properties of background K+ channels, and play a crucial role in setting the resting membrane potential and regulating cell excitability.... -
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- Autoantigenic Role of Variant Thyroperoxidase
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Shong YK, Moon DH, Kim GS
- KMID: 2461605
- J Korean Soc Endocrinol.
- 1996 Mar;11(1):61-67.
Background: Thyroperoxidase(TPO) is one of the most important autoantigens in autoimmune thyroid disorders and autoantibody to TPO is found in almost every patients with various autoimmune thyroid diseases. Human TPO... -
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- Identification and characterization of peroxisome proliferator response element in the mouse GLUT2 promoter
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Im SS, Kim JW, Kim TH, Song XL, Kim SY, Kim HI, Ahn YH
- KMID: 755748
- Exp Mol Med.
- 2005 Apr;37(2):101-110.
In the present study, we show that the expression of type 2 glucose transporter isoform (GLUT2) could be regulated by PPAR-gamma in the liver. Rosiglitazone, PPAR-gamma agonist, activated the GLUT2... -
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- IL-33 promotes IL-10 production in macrophages: a role for IL-33 in macrophage foam cell formation
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Zhang HF, Wu MX, Lin YQ, Xie SL, Huang TC, Liu PM, Nie RQ, Meng QQ, Luo NS, Chen YX, Wang JF
- KMID: 2396793
- Exp Mol Med.
- 2017 Nov;49(11):e388.
- doi: 10.1038/emm.2017.183
We evaluated the role of IL-10- in IL-33-mediated cholesterol reduction in macrophage-derived foam cells (MFCs) and the mechanism by which IL-33 upregulates IL-10. Serum IL-33 and IL-10 levels in coronary... -
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- The Binding Properties of Glycosylated and Non-Glycosylated Tim-3 Molecules on CD4+CD25+ T Cells
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Lee MJ, Heo YM, Hong SH, Kim K, Park S
- KMID: 1474596
- Immune Netw.
- 2009 Apr;9(2):58-63.
- doi: 10.4110/in.2009.9.2.58
BACKGROUND: T cell immunoglobulin and mucin domain containing 3 protein (Tim-3) expressed on terminally differentiated Th1 cells plays a suppressive role in Th1-mediated immune responses. Recently, it has been shown... -
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- Safety and immunogenicity of recombinant rabies virus (ERAGS) in mice and raccoon dogs
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Yang DK, Kim HH, Choi SS, Kim JT, Lee KB, Lee SH, Cho IS
- KMID: 2421563
- Clin Exp Vaccine Res.
- 2016 Jul;5(2):159-168.
- doi: 10.7774/cevr.2016.5.2.159
PURPOSE: The development of a genetically modified live rabies vaccine applicable to wild raccoon dogs is necessary for the eradication of rabies in Korea. Thus, we constructed a recombinant rabies... -
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- The role of tonicity responsive enhancer sites in the transcriptional regulation of human hsp70-2 in response to hypertonic stress
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Heo JI, Lee MS, Kim JH, Lee JS, Kim J, Park JB, Lee JY, Han JA, Kim JI
- KMID: 1094155
- Exp Mol Med.
- 2006 Jun;38(3):295-301.
The inducible 70 kDa heat shock proteins (Hsp70) in mice are encoded by two almost identical genes, hsp70.1 and hsp70.3. Studies have found that only hsp70.1 is induced by hypertonic... -
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- Development of two novel nontoxic mutants of Escherichia coli heat-labile enterotoxin
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Park EJ, Chang JH, Kim JS, Chung SI, Yum JS
- KMID: 1029939
- Exp Mol Med.
- 1999 Jun;31(2):101-107.
Escherichia coli heat-labile enterotoxin (LT) is composed of catalytic A and non-catalytic homo-pentameric B subunits and causes diarrheal disease in human and animals. In order to produce a nontoxic LT for vaccine... -
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- Translational Read-Through of a Nonsense Mutation Causing Bartter Syndrome
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Cho HY, Lee BH, Cheong HI
- KMID: 2158027
- J Korean Med Sci.
- 2013 Jun;28(6):821-826.
- doi: 10.3346/jkms.2013.28.6.821
Bartter syndrome (BS) is classified into 5 genotypes according to underlying mutant genes and BS III is caused by loss-of-function mutations in the CLCNKB gene encoding for basolateral ClC-Kb. BS... -
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