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Aldosterone Inhibits In Vitro Myogenesis by Increasing Intracellular Oxidative Stress via Mineralocorticoid Receptor

Lee JY, Kim DA, Choi E, Lee YS, Park SJ, Kim BJ

Background: Despite clinical evidence indicating poor muscle health in subjects with primary aldosteronism (PA), it is still unclear whether the role of aldosterone in muscle metabolism is direct or mediated...
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Effect of CCL11 on In Vitro Myogenesis and Its Clinical Relevance for Sarcopenia in Older Adults

Kim DA, Park SJ, Lee JY, Kim JH, Lee S, Lee E, Jang IY, Jung HW, Park JH, Kim BJ

Background: The C-C motif chemokine ligand 11 (CCL11) has been receiving attention as a potential pro-aging factor. Accordingly, it may be involved in muscle metabolism and sarcopenia, a key component...
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Secretion of adenylate kinase 1 is required for extracellular ATP synthesis in C2C12 myotubes

Choo HJ, Kim BW, Kwon OB, Lee CS, Choi JS, Ko YG

Extracellular ATP (exATP) has been known to be a critical ligand regulating skeletal muscle differentiation and contractibility. ExATP synthesis was greatly increased with the high level of adenylate kinase 1...
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