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Tissue engineering a blood vessel substitute: the role of biomechanics

Nerem RM

The engineering of a functional blood vessel substitute has for a quarter of a century been a "holy grail" within the cardiovascular research community. Such a substitute must exhibit long...
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All-trans-retinoic acid attenuates neointima formation with acceleration of reendothelialization in balloon-injured rat aorta

Lee CW, Park SJ, Park SW, Kim JJ, Hong MK, Song JK

Retinoic acids may inhibit vascular smooth muscle cell proliferation, but may promote endothelial cell proliferation in cell culture. However, little data are available about the effects of all-trans-retinoic acid (ATRA)...
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Membrane stretch increases the activity of Ca(2+)-activated K+ channels in rabbit coronary vascular smooth muscles

Lee CJ, Kwon S, Lee YH, Ahn DS, Kang BS

It has been proposed that Ca(2+)-activated K+ channels play an essential role in maintaining vascular tone during stretch of blood vessel. However, the underlying mechanism of stretch-induced change of Ca(2+)-activated...
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In vitro model of atherosclerosis using coculture of arterial wall cells and macrophage

Wada Y, Sugiyama A, Kohro T, Kobayashi , Takeya M, Naito M, Kodama T

In order to determine the precise mechanism of the interactions between different types of cells, which are common phenomena in tissues and organs, the importance of coculture techniques are becoming...
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