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Receptor-Mediated Muscle Homeostasis as a Target for Sarcopenia Therapeutics

Yoon JH, Kwon KS

Sarcopenia is a disease characterized by age-related decline of skeletal muscle mass and function. The molecular mechanisms of the pathophysiology of sarcopenia form a complex network due to the involvement...
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Reference Values for Skeletal Muscle Mass at the Third Lumbar Vertebral Level Measured by Computed Tomography in a Healthy Korean Population

Yoon JK, Lee S, Kim KW, Lee JE, Hwang JA, Park T, Lee J

Background: Sarcopenia is defined as the loss of skeletal muscle mass and is associated with negative clinical outcomes. This study aimed to establish sex-specific cutoff values for the skeletal muscle...
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MondoA Is Required for Normal Myogenesis and Regulation of the Skeletal Muscle Glycogen Content in Mice

Ran H, Lu Y, Zhang Q, Hu Q, Zhao J, Wang K, Tong X, Su Q

Background Skeletal muscle is the largest tissue in the human body, and it plays a major role in exerting force and maintaining metabolism homeostasis. The role of muscle transcription factors in...
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Age- and Sex-Related Differential Associations between Body Composition and Diabetes Mellitus

Roh E, Hwang SY, Kim JA, Lee YB, Hong Sh, Kim NH, Seo JA, Kim SG, Kim NH, Choi KM, Baik SH, Yoo HJ

Background The age- and sex-related differences on the impacts of body composition on diabetes mellitus (DM) remain uncertain. Methods The fourth and fifth Korea National Health and Nutrition Examination Survey included 15,586 subjects...
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Rodent Model of Muscular Atrophy for Sarcopenia Study

Baek KW, Jung YK, Kim JS, Park JS, Hah YS, Kim SJ, Yoo JI

The hallmark symptom of sarcopenia is the loss of muscle mass and strength without the loss of overall body weight. Sarcopenia patients are likely to have worse clinical outcomes and...
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Impact of Skeletal Muscle Mass on Metabolic Health

Kim G, Kim JH

Skeletal muscle is regarded as an endocrine and paracrine organ. Muscle-derived secretory proteins, referred to as myokines, mediate interactions between skeletal muscle mass and other organs such as the liver,...
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MRI Findings of Accessory Popliteus Muscle: A Case Report

Hahn HJ, Shim JC, Kim KH, Lee KE, Hwang DH, Lee GJ, Kim HK

Accessory muscles located in the region of the popliteal fossa are very rare. MRI scan performed in a 52-year-old man with right knee pain revealed an anomalous muscle in the...
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Proportion and Characteristics of the Subjects with Low Muscle Mass and Abdominal Obesity among the Newly Diagnosed and Drug-Naïve Type 2 Diabetes Mellitus Patients

Kim JA, Hwang SY, Chung HS, Kim NH, Seo JA, Kim SG, Kim NH, Choi KM, Baik SH, Yoo HJ

BACKGROUND: Sarcopenic obesity (SO) is a serious public health concern, few studies have examined the clinical implications of SO in newly-diagnosed type 2 diabetes mellitus (T2DM) patients. We evaluated the...
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Arginine methylation as a key post-translational modification in skeletal muscle homeostasis: a review

Kim H, Kang JS, Jeong HJ

Arginine methylation mediated by protein arginine methyltransferases (PRMTs) has emerged as a key post-translational modification of histone or nonhistone substrates. It involves or controls signaling pathways or gene expression implicated...
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Longitudinal Changes of Body Composition Phenotypes and Their Association with Incident Type 2 Diabetes Mellitus during a 5-Year Follow-up in Koreans

Kim HK, Lee MJ, Kim EH, Bae SJ, Choe J, Kim CH, Park JY

BACKGROUND: To elucidate longitudinal changes of complex body composition phenotypes and their association with incident type 2 diabetes mellitus. METHODS: A total of 17,280 (mean age, 48.1±8.2 years) Korean adults who...
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Association of Thigh Muscle Mass with Insulin Resistance and Incident Type 2 Diabetes Mellitus in Japanese Americans

Han SJ, Boyko EJ, Kim SK, Fujimoto W, Kahn SE, Leonetti D

BACKGROUND: Skeletal muscle plays a major role in glucose metabolism. We investigated the association between thigh muscle mass, insulin resistance, and incident type 2 diabetes mellitus (T2DM) risk. In addition,...
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Hyperglycemia Is Associated with Impaired Muscle Quality in Older Men with Diabetes: The Korean Longitudinal Study on Health and Aging

Yoon JW, Ha YC, Kim KM, Moon JH, Choi SH, Lim S, Park YJ, Lim JY, Kim KW, Park KS, Jang HC

BACKGROUND: The study aimed to investigate the influence of hyperglycemia on muscle quality in older men with type 2 diabetes. METHODS: This was a subsidiary study of the Korean Longitudinal Study...
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Connecting Myokines and Metabolism

Ahima RS, Park HK

Skeletal muscle is the largest organ of the body in non-obese individuals and is now considered to be an endocrine organ. Hormones (myokines) secreted by skeletal muscle mediate communications between...
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Intramuscular Hemangioma in the Anterior Scalene Muscle Diagnosed by Core Needle Biopsy

Cho JK, Cha W, Sung MW

Intramuscular hemangioma (IMH) is a rare, benign vascular lesion that frequently develops within skeletal muscles. Preoperatively, accurate diagnosis of IMH is often extremely difficult because of nonspecific clinical findings and...
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A Case of Extrahepatic Metastasis of Hepatocellular Carcinoma to the Pronator Quadratus Muscle of Right Wrist

Song YW, Lee BS, Kim SH, Lee ES, Lee HY

Hepatocellular carcinoma (HCC) is usually associated with chronic liver disease such as liver cirrhosis. Primary HCC lesions and even recurrent intrahepatic lesions can be treated successfully by using variable modalities...
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Skeletal Muscle Metastasis and Elevated beta-HCG Level Secondary to Tongue Cancer: a Case Report and Review of Literature

Ham JS, Hwang KB, Hwang S, Jeong SH, Lee JY, Lee SH, Park K

Metastases to skeletal muscle and paraneoplastic syndromes involving beta-human chorionic gonadotropin (HCG) production are an extremely rare manifestation of head and neck squamous cell carcinoma. We report a patient with...
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The Role of Skeletal Muscle in Development of Nonalcoholic Fatty Liver Disease

Moon JS, Yoon JS, Won KC, Lee HW

BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is closely correlated with abnormal accumulation of visceral fat, but the role of skeletal muscle remains unclear. The aim of this study was to...
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Expression of Thyroid Stimulating Hormone Receptor mRNA in Mouse C2C12 Skeletal Muscle Cells

Ohn JH, Han SK, Park DJ, Park KS, Park YJ

BACKGROUND: We analyzed whether thyroid stimulating hormone receptor (TSH-R) is expressed in a skeletal muscle cell line and if TSH has influence on the differentiation of muscle cells or on...
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Relative Skeletal Muscle Mass Is Associated with Development of Metabolic Syndrome

Park BS, Yoon JS

BACKGROUND: Visceral adiposity is related to insulin resistance. Skeletal muscle plays a central role in insulin-mediated glucose disposal; however, little is known about the association between muscle mass and metabolic...
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Effects of Rosiglitazone on Inflammation in Otsuka Long-Evans Tokushima Fatty Rats

Lee JW, Nam-Goong , Kim JG, Yun CH, Kim SJ, Choi JI, Kim YI, Kim ES

BACKGROUND: Inflammation plays a role in the response to metabolic stress in type 2 diabetes. However, the effects of rosiglitazone on inflammation of skeletal muscle have not been fully examined...
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