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Detection of Targetable Genetic Alterations in Korean Lung CancerPatients: A Comparison Study of Single-Gene Assays andTargeted Next-Generation Sequencing

Park E, Shim HS

Purpose Epidermal growth factor receptor (EGFR), anaplastic lymphoma kinase (ALK), and ROS proto-oncogene 1 (ROS1) are ‘must-test’ biomarkers in the molecular diagnostics of advanced- stage lung cancer patients. Although single-gene assays are currently...
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Understandings and Prospects of Laboratory Diagnosis of SARS-CoV-2

Kim JS

In 2019, a novel betacoronavirus, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), was detected in the Chinese city of Wuhan. SARS-CoV-2 caused a severe form of pneumonias which is closely...
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Optimization of ultra-fast convection polymerase chain reaction conditions for pathogen detection with nucleic acid lateral flow immunoassay

Kim TH, Hwang HJ, Kim JH

Recently, the importance of on-site detection of pathogens has drawn attention in the field of molecular diagnostics. Unlike in a laboratory environment, on-site detection of pathogens is performed under limited...
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Recent Advancement of the Molecular Diagnosis in Pediatric Brain Tumor

Bae JM, Won JK, Park SH

Recent discoveries of brain tumor-related genes and fast advances in genomic testing technologies have led to the era of molecular diagnosis of brain tumor. Molecular profiling of brain tumor became...
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Molecular Testing of Lymphoproliferative Disorders: Current Status and Perspectives

Jeon YK, Yoon SO, Paik JH, Kim YA, Shin BK, Kim HJ, Cha HJ, Kim JE, Huh J, Ko YH, The Hematopathology Study Group of the Korean Society of Pathologists, The Molecular Pathology Study Group of Korean Society of Pathologists

Molecular pathologic testing plays an important role for the diagnosis, prognostication and decision of treatment strategy in lymphoproliferative disease. Here, we briefly review the molecular tests currently used for lymphoproliferative...
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Comparison of Luminex NxTAG Respiratory Pathogen Panel and xTAG Respiratory Viral Panel FAST Version 2 for the Detection of Respiratory Viruses

Lee CK, Lee HK, Ng CW, Chiu L, Tang JW, Loh TP, Koay ES

Owing to advancements in molecular diagnostics, recent years have seen an increasing number of laboratories adopting respiratory viral panels to detect respiratory pathogens. In December 2015, the NxTAG respiratory pathogen...
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Origins and History of Laboratory Medicine

Lee HJ, Oh SH, Chang CL

Medical diagnostics plays a significant role in clinical decisions. The first medical laboratory test to be developed was urine analysis, in which urine properties were analyzed for diagnosis. Urine analysis...
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External Quality Assessment of MERS-CoV Molecular Diagnostics During the 2015 Korean Outbreak

Seong MW, Lee SJ, Cho SI, Ko K, Kim MN, Sung H, Kim JS, Ahn JS, Yu BS, Kim TS, Kim EC, Park SS

BACKGROUND: The largest outbreak of Middle East respiratory syndrome coronavirus (MERS-CoV) infection outside Middle East Asia in 2015 has necessitated the rapid expansion of laboratories that conduct MERS-CoV molecular testing...
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Identification of Staphylococcus pseudintermedius in canine infective endocarditis using PCR-RFLP analysis

Lee CM, Kang MH, Chae MJ, Yoon JW, Park HM

A 5-year-old, 8.95 kg, female Schnauzer presented anorexia with a 3-day history and increased heart sound intensity. Based on the clinical and echocardiographic findings along with the positive blood culture...
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Evaluation of ExiPrep16 Automated System for the Extraction of Nucleic Acids from Nasopharyngeal Swabs for the Detection of Respiratory Viruses

Lee KS, Park DS, Yoon KH, Lee YJ, Cho JH

  • KMID: 2312228
  • Lab Med Online.
  • 2013 Oct;3(4):227-233.
BACKGROUND: Automated nucleic acid extraction offers a standardized sample treatment method, low error rate, and avoids sample nucleic acid contamination for use in molecular diagnostics. Here, we evaluated the performance...
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