- Cellular NAD⺠Level: A Key Determinant of Mitochondrial Quality and Health
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Hwang ES, Hwang SY
- KMID: 2401128
- Ann Geriatr Med Res.
- 2017 Dec;21(4):149-157.
- doi: 10.4235/agmr.2017.21.4.149
The quality of mitochondria is a key determinant of mitochondrial ATP production and reactive oxygen species generation; therefore, it plays critical roles in energy homeostasis and cellular health. Mitochondrial quality... -
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- Post-Translational Modifications of Cardiac Mitochondrial Proteins in Cardiovascular Disease: Not Lost in Translation
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Marquez J, Lee SR, Kim N, Han J
- KMID: 2223763
- Korean Circ J.
- 2016 Jan;46(1):1-12.
- doi: 10.4070/kcj.2016.46.1.1
Protein post-translational modifications (PTMs) are crucial in regulating cellular biology by playing key roles in processes such as the rapid on and off switching of signaling network and the regulation... -
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- miR-27 regulates mitochondrial networks by directly targeting the mitochondrial fission factor
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Tak H, Kim J, Jayabalan , Lee H, Kang H, Cho DH, Ohn T, Nam SW, Kim W, Lee EK
- KMID: 2155388
- Exp Mol Med.
- 2014 Nov;46(11):e123.
- doi: 10.1038/emm.2014.73
Mitochondrial morphology is dynamically regulated by forming small, fragmented units or interconnected networks, and this is a pivotal process that is used to maintain mitochondrial homeostasis. Although dysregulation of mitochondrial... -
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- Mitochondrial Protein Nfu1 Influences Homeostasis of Essential Metals in the Human Fungal Pathogen Cryptococcus neoformans
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Kim J, Park M, Do E, Jung WH
- KMID: 2408979
- Mycobiology.
- 2014 Dec;42(4):427-431.
- doi: 10.5941/MYCO.2014.42.4.427
Mitochondrial protein Nfu1 plays an important role in the assembly of mitochondrial Fe-S clusters and intracellular iron homeostasis in the model yeast Saccharomyces cerevisiae. In this study, we identified the... -
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- Positioning Metabolism as a Central Player in the Diabetic Heart
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Mereweather LJ, Montes Aparicio CN, Heather LC
- KMID: 2470803
- J Lipid Atheroscler.
- 2020 Jan;9(1):92-109.
- doi: 10.12997/jla.2020.9.1.92
In type 2 diabetes (T2D), the leading cause of death is cardiovascular complications. One mechanism contributing to cardiac pathogenesis is alterations in metabolism, with the diabetic heart exhibiting increased fatty... -
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- Peroxiredoxin-3 Is Involved in Bactericidal Activity through the Regulation of Mitochondrial Reactive Oxygen Species
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Lee S, Wi SM, Min Y, Lee KY
- KMID: 2362802
- Immune Netw.
- 2016 Dec;16(6):373-380.
- doi: 10.4110/in.2016.16.6.373
Peroxiredoxin-3 (Prdx3) is a mitochondrial protein of the thioredoxin family of antioxidant peroxidases and is the principal peroxidase responsible for metabolizing mitochondrial hydrogen peroxide. Recent reports have shown that mitochondrial... -
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- Mitochondrial Control of Innate Immunity and Inflammation
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Jin HS, Suh HW, Kim SJ, Jo EK
- KMID: 2376865
- Immune Netw.
- 2017 Apr;17(2):77-88.
- doi: 10.4110/in.2017.17.2.77
Mitochondria are key organelles involved in energy production, functioning as the metabolic hubs of cells. Recent findings emphasize the emerging role of the mitochondrion as a key intracellular signaling platform... -
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- Reactive Oxygen Species Modulator 1 (ROMO1), a New Potential Target for Cancer Diagnosis and Treatment
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Amini MA, Talebi SS, Karimi J
- KMID: 2458565
- Chonnam Med J.
- 2019 Sep;55(3):136-143.
- doi: 10.4068/cmj.2019.55.3.136
Today, the incidence of cancer in the world is rising, and it is expected that in the next several decades, the number of people suffering from cancer or (the cancer... -
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- A Case of Diphyllobothrium nihonkaiense Infection as Confirmed by Mitochondrial COX1 Gene Sequence Analysis
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Park SH, Eom KS, Park MS, Kwon OK, Kim HS, Yoon JH
- KMID: 1715695
- Korean J Parasitol.
- 2013 Aug;51(4):471-473.
- doi: 10.3347/kjp.2013.51.4.471
Diphyllobothrium nihonkaiense has been reported in Korea as Diphyllobothrium latum because of their close morphologic resemblance. We have identified a human case of D. nihonkaiense infection using the mitochondrial cytochrome... -
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- Mitochondrial Permeability Transition Pore and Cardioprotection Against Ischemia-reperfusion Injury
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Lee JW, Shim YH
- KMID: 2188082
- J Korean Med Assoc.
- 2009 Oct;52(10):1007-1019.
- doi: 10.5124/jkma.2009.52.10.1007
Opening of mitochondrial permeability transition pore (mPTP) was found to have a critical role in cell death from ischemia/reperfusion (I/R) injury experimentally in the late 1980's. Thereafter, tremendous efforts have... -
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- Systematic Analysis of Translocator Protein 18 kDa (TSPO) Ligands on Toll-like Receptors-mediated Pro-inflammatory Responses in Microglia and Astrocytes
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Lee JW, Nam H, Yu SW
- KMID: 2354879
- Exp Neurobiol.
- 2016 Oct;25(5):262-268.
- doi: 10.5607/en.2016.25.5.262
Translocator protein 18 kDa (TSPO) is a mitochondrial protein highly expressed on reactive microglia and astrocytes, and is considered as a biomarker for neurodegeneration and brain damage, especially neuroinflammation. Toll-like... -
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- Temporal Characteristics of Cytosolic Translocation of Mitochondrial Proteins in Permanent Distal Middle Cerebral Artery Occlusion Model of Rats
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Shin BW, Sung JH, Hong JT, Son BC, Lee SW, Park CK
- KMID: 2118517
- J Korean Neurosurg Soc.
- 2007 May;41(5):306-313.
OBJECTIVE: In permanent distal middle cerebral artery occlusion (pdMCAO) model of rats, the temporal order of subcellular translocation is not fully understood yet. We studied translocation sequence of cytochrome c... -
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- Up-regulation of Bax and endonuclease G, and down-modulation of Bcl-X(L) involved in cardiotoxin III-induced apoptosis in K562 cells
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Yang SH, Chien CM, Lu MC, Lin YH, Hu XW, Lin SR
- KMID: 1110128
- Exp Mol Med.
- 2006 Aug;38(4):435-444.
Cardiotoxin III (CTX III), a basic polypeptide with 60 amino acid residues isolated from Naja naja atra venom, has been reported to have anticancer activity. CTX III-induced K562 cell apoptosis... -
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- Tumor Necrosis Factor-Associated Protein 1 (TRAP1) is Released from the Mitochondria Following 6-hydroxydopamine Treatment
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Shin DI, Oh YJ
- KMID: 2009026
- Exp Neurobiol.
- 2014 Mar;23(1):65-76.
- doi: 10.5607/en.2014.23.1.65
Parkinson's disease (PD) is a common neurodegenerative disorder characterized by progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta. Most cases are sporadic and its etiology is incompletely... -
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- Detection of O-Linked-N-Acetylglucosamine Modification and Its Associated Enzymes in Human Degenerated Intervertebral Discs
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Nikolaou G, Zibis AH, Fyllos AH, Katsioulis A, Sotiriou S, Kotrotsios A, Sgantzos M, Vassiou A, Arvanitis
- KMID: 2397623
- Asian Spine J.
- 2017 Dec;11(6):863-869.
- doi: 10.4184/asj.2017.11.6.863
STUDY DESIGN: Human herniated discs were obtained from discectomy specimens for the immunohistochemical detection of O-GlcNAc and O-GlcNAcase (OGA)/O-GlcNAc transferase (OGT). PURPOSE: This study aimed to quantify the extent of O-GlcNAcylation... -
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- Inhibitors of Apoptosis Proteins Expression and Their Prognostic Significance in Colorectal Carcinoma
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Lee KH, Lee S, Lee HM, Back SC, Cho SB, Lee JH
- KMID: 2277504
- Korean J Pathol.
- 2011 Aug;45(4):397-405.
BACKGROUND: The expression of the inhibitor of apoptosis proteins (IAPs) family has not been fully investigated in colorectal carcinomas. This study investigated IAP expression in colorectal carcinomas and assessed their... -
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- Effect of Ovariectomy and Genistein on Hepatic Mitochondrial Function
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Lee YM, Jung MH, Lee YS, Song J
- KMID: 2269803
- Korean J Nutr.
- 2004 Nov;37(9):786-793.
Women with menopause or rats with ovariectomy is associated with increased body weight, body fat and insulin resistance, which are components of metabolic syndrome. Increased prevalence of metabolic syndrome after... -
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- Recent Research Trend for Ménière's Disease
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Nam SI
- KMID: 2385913
- Res Vestib Sci.
- 2017 Jun;16(2):39-46.
- doi: 10.21790/rvs.2017.16.2.39
Ménière's disease is a poorly understood disorder of the inner ear characterized by intermittent episodic vertigo, fluctuating hearing loss, ear fullness and tinnitus. In this paper, we present a review... -
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- Niacinamide Protects Skin Cells from Oxidative Stress Induced by Particulate Matter
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Zhen AX, Piao MJ, Kang KA, Madushan Fernando PDS, Kang HK, Koh YS, Yi JM, Hyun JW
- KMID: 2462883
- Biomol Ther.
- 2019 Nov;27(6):562-569.
- doi: 10.4062/biomolther.2019.061
Niacinamide (NIA) is a water-soluble vitamin that is widely used in the treatment of skin diseases. Moreover, NIA displays antioxidant effects and helps repair damaged DNA. Recent studies showed that... -
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- A MELAS syndrome family harboring two mutations in mitochondrial genome
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Choi BO, Hwang JH, Kim J, Cho EM, Cho SY, Hwang SJ, Lee HW, Kim SJ, Chung KW
- KMID: 756338
- Exp Mol Med.
- 2008 Jun;40(3):354-360.
- doi: 10.3858/emm.2008.40.3.354
Mitochondrial myopathy, encephalopathy, lactic acidosis, and stroke-like episodes (MELAS) syndrome is a genetically heterogeneous mitochondrial disorder with variable clinical symptoms. Here, from the sequencing of the entire mitochondrial genome, we... -
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