- Postnatal Development of Activities of MFO in Hepatic Microsomes from Rats Treated with Alcohol
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Kim KH
- KMID: 2052641
- Ewha Med J.
- 1991 Sep;14(3):223-228.
- doi: 10.12771/emj.1991.14.3.223
General concepts of hepatic drug-metabolizing enzymes in liver microsomes and the characteristics of induction of the enzyme are well known in adult rats. However there are few detailed reports on... -
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- Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes
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Joo SY, Lim YC
- KMID: 2334469
- J Korean Soc Clin Pharmacol Ther.
- 2011 Jun;19(1):52-58.
No abstract available. -
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- Effect of Thiamine Deficiency on Drug Hydroxylation and Level of Cytochrome P-450 in the Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969656
- Ewha Med J.
- 1979 Dec;2(4):195-199.
- doi: 10.12771/emj.1979.2.4.195
Our studies are concerned with cytochrome P-450 content and 2-acetylaminofluorene N-and ring-hydroxylation by thiamine deficient rat liver microsomes. Incubation medium contained 100mM HEPES buffer pH 7.8, 2mM NADPH, 100mM KF,... -
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- The Effects of Vitamin Antioxidants on Lipid Peroxidation in Rat Liver Microsomes
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Ham YA, Hong YS, Sung NE
- KMID: 1969220
- Ewha Med J.
- 1982 Sep;5(3):109-116.
- doi: 10.12771/emj.1982.5.3.109
We observed the effect of the administration of vitamin A,C and E with beta-naphthoflavone and piperonyl butoxide on cytochrome P-450 level and lipid peroxidation in rats liver. The level of... -
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- The Effects of Vitamin A and E on Lipid Peroxidation in Ethanol Administered Rat Liver Microsomes
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Hong YS, Ham YA, Sung NE
- KMID: 2052611
- Ewha Med J.
- 1984 Mar;7(1):3-7.
- doi: 10.12771/emj.1984.7.1.3
Ethanol enhances the activity of microsomal enzyme system and lipid peroxidation. We observed the effect of chronic ethanol administration on cytochrome P-450 level and lipid peroxidation in rat liver microsome.... -
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- Enhancement of O-dealkylation in Mouse Liver by Dietary Administrations of BHA and BHT: Studies with Isolated Perfused Livers and Hepatic Microsomes
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Ji SC, Conway JG, Thurman RG, Cha YN
- KMID: 693021
- Yonsei Med J.
- 1986 Jun;27(2):106-113.
- doi: 10.3349/ymj.1986.27.2.106
Effects of feeding 2(3)-tert-butyl 4-hydroxyanisole (BHA) and 3, 5-di-tert-butyl 4-hydroxytoluene (BHT) on the rates of mixed function oxidation and conjugation enzyme reactions have been determined using isolated hepatic microsomal fractions... -
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- The Effect of Phenobarbital on the Monooxygenase System in the Liver Microsomes of Neonatal, Immature and Adult Rats
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Hong YS, Lee JS
- KMID: 2052626
- Ewha Med J.
- 1988 Sep;11(3):131-142.
- doi: 10.12771/emj.1988.11.3.131
A variety of compounds including drugs, carcinogens, steroids and fatty acids are metabolized by microsomal monooxygenase system in the liver. The effect of phenobarbital(PB) on the monooxygenase system in the... -
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- Study on Mixed Function and Lipid Peroxidation of Neonatal Hepatic Microsomes after Exposure to Alcohol During the Fetal and Lactating Period
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Hong YS, Ham YA, Lee HL
- KMID: 1965786
- Ewha Med J.
- 1989 Sep;12(3):145-150.
- doi: 10.12771/emj.1989.12.3.145
Maternal ingestion of alcohol produce not only change of drug metabolism but also proliferation of hepatic smooth endoplasmic reticulum and many developmental defects of the central nervous system. The present investigation... -
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- Comparison of the Glucurinidation Ability of Liver Microsomes from Rats Treated with Alcohol
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Kim KH
- KMID: 1965224
- Ewha Med J.
- 1990 Sep;13(3):149-155.
- doi: 10.12771/emj.1990.13.3.149
Glucuronidation is low or undectable in embryonic and early fetal tissues and changes to adult levels at rates depending on the acceptor, tissue and species. The present investigation examined the effects... -
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- Reduction in Binding of Aflatoxin B1 to Rat Liver DNA by Vitamin A and E Pretreatment
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Hong YS
- KMID: 1967556
- Ewha Med J.
- 1984 Jun;7(2):71-78.
- doi: 10.12771/emj.1984.7.2.71
We examined pattern of covalent modification of DNA produced in rat liver after exposure to single dose of aflatoxin B1. DNA-bound aflatoxin B1 adducts obtained from rat liver microsomes were... -
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- The Inhibitory Effect of the Second Generation Sulfonylurea Drugs on Cytochrome P450-catalyzed Reaction by Human Liver Microsomes
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Choi JY, Kim SY, Kim KA, Park JY
- KMID: 2199993
- J Korean Soc Endocrinol.
- 2002 Aug;17(4):544-553.
BACKGROUND: Sulfonylurea drugs have been used for many decades as one of the main families of drugs for the treatment of type 2 diabetes mellitus. Even though there are many... -
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- The Effects of Vitamin Antioxidants on Lipid Peroxidation in Carbon Tetrachloride, Phenobarbital and Artemisia Messes - Schmidiana Var Viridis - Preteated Rats Liver Microsomes
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Han EK, Hong YS, Sung HE, Pae YS
- KMID: 2009002
- Ewha Med J.
- 1983 Jun;6(2):57-64.
- doi: 10.12771/emj.1983.6.2.57
After rats were treated with CC14, phenobarbital and artemisia messes-schmiaiana var viridis(artemisia), hepatic microsomal cytochrome P-450, cytochrome b5 and lipid peroxidation were investigated. When vitamin A, C and E were... -
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- Induction of Hepatic Microsomal Cytochrome P450 by Styrene in Rat
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Kim KW, Chang SK, Joung HS, Lee JY, Moon YH, Park SS
- KMID: 1529816
- Korean J Occup Environ Med.
- 1997 Dec;9(4):604-613.
The effects of styrene on the induction of cytochrome P-450s (P450), (P4501A1/2, P4502B1/2 and P4502El) and activities of other related enzymes were investigated in the male Sprague Dawley rats which... -
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- Effect of Naloxone on the Mixed- Function Oxidation and Lipid Peroxidation in Rat Liver Microsomes
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Hong YS, Sung NE, Pae YS
- KMID: 1965692
- Ewha Med J.
- 1986 Sep;9(3):153-161.
- doi: 10.12771/emj.1986.9.3.153
The effects of Naloxone, narcotic antagonist, pretreated with normal saline, salicylate and hydrocortisone produced by with hypovolemic shock on the rates of cytochrome components, mixed function oxidation enzyme reactions and... -
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- Induction of Hepatic Microsomal UDP-Glucuronosyltransferase Activity in Nifedipine Treated Rats
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Hong YS, Pae YS
- KMID: 1965213
- Ewha Med J.
- 1990 Jun;13(2):45-51.
- doi: 10.12771/emj.1990.13.2.45
UDP-Glucuronosyltransferase(UDPGT) activity was studies in hepatic microsomal preparation from rats treated with nifedipine. The substrates 1-naphthol, P-nitrophenol, 4-methyl-umbelliferone and bilirubine were used. With 1-naphthol, nifedipine 2 and 4 weeks treatment... -
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- The Effects of Phenobarbital or Cholic Acid on Hepatic Microsomal Cytochrome P450 and Hydroxylation of 2-AAF in Cholestatic Rats
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Kim BH, Hong YS, Sung NE
- KMID: 1969538
- Ewha Med J.
- 1981 Sep;4(3):83-89.
- doi: 10.12771/emj.1981.4.3.83
In cholestatic rats, effects of phenobarbital or cholic acid on hepatic microsomal cytochrome p-450 and b5 were investigated. The total contents of both cytochrome p-450 and cytochrome b5 were decreased... -
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- Effect of Nifedipine on Induction of Cytochrome P-450 1A1 and 2B1 in Spontaneously Hypertensive Rate
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Hong YS, Kim HL, Park HY, Pae YS, Park SS
- KMID: 1964943
- Ewha Med J.
- 1995 Sep;18(3):161-167.
- doi: 10.12771/emj.1995.18.3.161
Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker... -
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- Induction of Hepatic Microsomal Cytochrome P450 by N,N-dimethylformamide in Sprague-Dawley Rats
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Koh SB, Cha BS, Kim KJ, Kang SK, Joung HS
- KMID: 2282984
- Korean J Prev Med.
- 1999 Feb;32(1):88-94.
OBJECTIVES: In order to gain a better understanding of the mechanism of DMF toxicity, recent studies have focused on hepatic drug metabolizing enzymes. In this study, we investigated the effects... -
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- An NH(2)-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
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Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY
- KMID: 1052948
- Exp Mol Med.
- 2008 Apr;40(2):254-260.
- doi: 10.3858/emm.2008.40.2.254
Cytochrome P450 3A4 (CYP3A4), is the dominant human liver hemoprotein enzyme localized in the endoplasmic reticulum (ER), and is responsible for the metabolism of more than 50% of clinically relevant... -
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- A Study of the Regulation of the Glucose Transporter in the Plasma Membranes of Hepatoma Cells Induced by 3'-Me DAB
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Ahn YH, Chai KJ, Kim SN, Kim YS
- KMID: 693085
- Yonsei Med J.
- 1987 Sep;28(3):192-198.
- doi: 10.3349/ymj.1987.28.3.192
5'-nucelotidase and glucose-6-phosphatase are liver plasma and microsomal membranes markers and their respective activities were determined. In the liver homogenate, the activities of 5'-nucleotidase were 0.58 +/- 0.08 and 0.29... -
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