- Pharmacokinetic Interaction of Chrysin with Caffeine in Rats
-
Noh K, Oh DG, Nepal MR, Jeong KS, Choi Y, Kang MJ, Kang W, Jeong HG, Jeong TC
- KMID: 2351695
- Biomol Ther.
- 2016 Jul;24(4):446-452.
- doi: 10.4062/biomolther.2015.197
Pharmacokinetic interaction of chrysin, a flavone present in honey, propolis and herbs, with caffeine was investigated in male Sprague-Dawley rats. Because chrysin inhibited CYP1A-selective ethoxyresorufin O-deethylase and methoxyresorufin O-demethylase activities... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Baicalin on Oral Pharmacokinetics of Caffeine in Rats
-
Noh K, Nepal MR, Jeong KS, Kim SA, Um YJ, Seo CS, Kang MJ, Park PH, Kang W, Jeong HG, Jeong TC
- KMID: 2380355
- Biomol Ther.
- 2015 Mar;23(2):201-206.
- doi: 10.4062/biomolther.2014.134
Scutellaria baicalensis is one of the most widely used herbal medicines in East Asia. Because baicalein and baicalin are major components of this herb, it is important to understand the... -
- CITED
-
- Close
- SHARE
-
- Close
- A Comparison of the In Vitro Inhibitory Effects of Thelephoric Acid and SKF-525A on Human Cytochrome P450 Activity
-
Song M, Do H, Kwon OK, Yang EJ, Bae JS, Jeong TC, Song KS, Lee S
- KMID: 2170656
- Biomol Ther.
- 2014 Mar;22(2):155-160.
Thelephoric acid is an antioxidant produced by the hydrolysis of polyozellin, which is isolated from Polyozellus multiplex. In the present study, the inhibitory effects of polyozellin and thelephoric acid on... -
- CITED
-
- Close
- SHARE
-
- Close
- Inhibitory Effects of 6-Gingerol on Cytochrome P450 in Human Liver Microsomes
-
Joo SY, Lim YC
- KMID: 2334469
- J Korean Soc Clin Pharmacol Ther.
- 2011 Jun;19(1):52-58.
No abstract available. -
- CITED
-
- Close
- SHARE
-
- Close
- An NH(2)-terminal truncated cytochrome P450 CYP3A4 showing catalytic activity is present in the cytoplasm of human liver cells
-
Jeon S, Kim KH, Yun CH, Hong BW, Chang YS, Han HS, Yoon YS, Choi WB, Kim S, Lee AY
- KMID: 1052948
- Exp Mol Med.
- 2008 Apr;40(2):254-260.
- doi: 10.3858/emm.2008.40.2.254
Cytochrome P450 3A4 (CYP3A4), is the dominant human liver hemoprotein enzyme localized in the endoplasmic reticulum (ER), and is responsible for the metabolism of more than 50% of clinically relevant... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of DHEA Administration on PUFA/SFA Ratio and Lipid Peroxide in Rat Liver Microsome
-
Kwak CS, Kim MY
- KMID: 2257565
- Korean J Nutr.
- 2005 May;38(4):297-306.
It is known that dehydroepiandrosterone (DHEA) shows a dual effect, prooxidant or antioxidant, depending on the dosage or physiological status of animals. The purpose of this study was to determine... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of diet on aflatoxin B1-DNA binding and aflatoxin B1-induced glutathione S-transferase placental form positive hepatic foci in the rat
-
Kimura M, Lehmann K, Gopalan-Kriczky P, Lotlikar P
- KMID: 1094079
- Exp Mol Med.
- 2004 Aug;36(4):351-357.
Effects of diets on hepatic aflatoxin B1 (AFB1)- DNA binding and AFB1-induced glutathione S- transferase placental (GST-P) form positive hepatic foci have been examined in young male Fischer rats. Animals... -
- CITED
-
- Close
- SHARE
-
- Close
- A Simple and Accurate Method for Determining Antioxidative Activity
-
Bae JW, Lee MH
- KMID: 1517044
- Korean J Physiol Pharmacol.
- 2003 Oct;7(5):275-278.
Antioxidative activity is an important factor in inhibiting oxidative stress. The usual methods for determining antioxidative activity are time-consuming and cumbersome. They are also indirect processes that use biological material... -
- CITED
-
- Close
- SHARE
-
- Close
- The Inhibitory Effect of the Second Generation Sulfonylurea Drugs on Cytochrome P450-catalyzed Reaction by Human Liver Microsomes
-
Choi JY, Kim SY, Kim KA, Park JY
- KMID: 2199993
- J Korean Soc Endocrinol.
- 2002 Aug;17(4):544-553.
BACKGROUND: Sulfonylurea drugs have been used for many decades as one of the main families of drugs for the treatment of type 2 diabetes mellitus. Even though there are many... -
- CITED
-
- Close
- SHARE
-
- Close
- Arylamine N-methyltransferase and thiol methyltransferase activities in cholestatic rat liver induced by common bile duct ligation
-
Kim YH, Joo I
- KMID: 755113
- Exp Mol Med.
- 2001 Mar;33(1):23-28.
Methylation catalyzed by methyltransferases is a major metabolic pathway for an inactivation of some catecholamines, niacinamide as well as aliphatic sulfhydryl drugs and toxic hydrogen sulfides. To investigate the effects... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of Hepatic Microsomal Cytochrome P450 by N,N-dimethylformamide in Sprague-Dawley Rats
-
Koh SB, Cha BS, Kim KJ, Kang SK, Joung HS
- KMID: 2282984
- Korean J Prev Med.
- 1999 Feb;32(1):88-94.
OBJECTIVES: In order to gain a better understanding of the mechanism of DMF toxicity, recent studies have focused on hepatic drug metabolizing enzymes. In this study, we investigated the effects... -
- CITED
-
- Close
- SHARE
-
- Close
- Effects of Ischemia/Reperfusion on Hepatic Secretion and Microsomal Drug- Metabolism in rat
-
Cho JP, Jung YS
- KMID: 2100503
- J Korean Soc Emerg Med.
- 1997 Dec;8(4):479-489.
Ischemia causes tissue necrosis in a wide variety of pathologic conditions. Permanent deprivation of blood flow is lethal to any tissue and the prudent therapy for ischemia unquestionably is reperfusion.... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of Hepatic Microsomal Cytochrome P450 by Styrene in Rat
-
Kim KW, Chang SK, Joung HS, Lee JY, Moon YH, Park SS
- KMID: 1529816
- Korean J Occup Environ Med.
- 1997 Dec;9(4):604-613.
The effects of styrene on the induction of cytochrome P-450s (P450), (P4501A1/2, P4502B1/2 and P4502El) and activities of other related enzymes were investigated in the male Sprague Dawley rats which... -
- CITED
-
- Close
- SHARE
-
- Close
- Effect of Nifedipine on Induction of Cytochrome P-450 1A1 and 2B1 in Spontaneously Hypertensive Rate
-
Hong YS, Kim HL, Park HY, Pae YS, Park SS
- KMID: 1964943
- Ewha Med J.
- 1995 Sep;18(3):161-167.
- doi: 10.12771/emj.1995.18.3.161
Cytochrome P-450(CYP) enzymes are important in catalyzing the hiotransffrmation on manyendogeneous compounds and xenobiotics, including drugs and carcinogens. In the presentstudy, effect of nifedipine a voltage dependent calcium channel blocker... -
- CITED
-
- Close
- SHARE
-
- Close
- Postnatal Development of Activities of MFO in Hepatic Microsomes from Rats Treated with Alcohol
-
Kim KH
- KMID: 2052641
- Ewha Med J.
- 1991 Sep;14(3):223-228.
- doi: 10.12771/emj.1991.14.3.223
General concepts of hepatic drug-metabolizing enzymes in liver microsomes and the characteristics of induction of the enzyme are well known in adult rats. However there are few detailed reports on... -
- CITED
-
- Close
- SHARE
-
- Close
- A study on the regulation of translocation of glucose transporters during hepatocarcinogenesis induced by 3'-Me DAB
-
Kim YS, Paik EM, Lee MS, Kim KS, Chai KJ, Ahn YH
- KMID: 1729578
- Yonsei Med J.
- 1990 Dec;31(4):315-324.
- doi: 10.3349/ymj.1990.31.4.315
The mechanism of glucose transported (GT) expression on the plasma membranes of hepatoma cells in rats induced by 3'-methyl-4-dimethylaminoazobenzene (3'-MeDAB) was studied. Cytochalasin B binding to plasma membrane fractions from... -
- CITED
-
- Close
- SHARE
-
- Close
- Comparison of the Glucurinidation Ability of Liver Microsomes from Rats Treated with Alcohol
-
Kim KH
- KMID: 1965224
- Ewha Med J.
- 1990 Sep;13(3):149-155.
- doi: 10.12771/emj.1990.13.3.149
Glucuronidation is low or undectable in embryonic and early fetal tissues and changes to adult levels at rates depending on the acceptor, tissue and species. The present investigation examined the effects... -
- CITED
-
- Close
- SHARE
-
- Close
- Induction of Hepatic Microsomal UDP-Glucuronosyltransferase Activity in Nifedipine Treated Rats
-
Hong YS, Pae YS
- KMID: 1965213
- Ewha Med J.
- 1990 Jun;13(2):45-51.
- doi: 10.12771/emj.1990.13.2.45
UDP-Glucuronosyltransferase(UDPGT) activity was studies in hepatic microsomal preparation from rats treated with nifedipine. The substrates 1-naphthol, P-nitrophenol, 4-methyl-umbelliferone and bilirubine were used. With 1-naphthol, nifedipine 2 and 4 weeks treatment... -
- CITED
-
- Close
- SHARE
-
- Close
- Study on Mixed Function and Lipid Peroxidation of Neonatal Hepatic Microsomes after Exposure to Alcohol During the Fetal and Lactating Period
-
Hong YS, Ham YA, Lee HL
- KMID: 1965786
- Ewha Med J.
- 1989 Sep;12(3):145-150.
- doi: 10.12771/emj.1989.12.3.145
Maternal ingestion of alcohol produce not only change of drug metabolism but also proliferation of hepatic smooth endoplasmic reticulum and many developmental defects of the central nervous system. The present investigation... -
- CITED
-
- Close
- SHARE
-
- Close
- The Effect of Phenobarbital on the Monooxygenase System in the Liver Microsomes of Neonatal, Immature and Adult Rats
-
Hong YS, Lee JS
- KMID: 2052626
- Ewha Med J.
- 1988 Sep;11(3):131-142.
- doi: 10.12771/emj.1988.11.3.131
A variety of compounds including drugs, carcinogens, steroids and fatty acids are metabolized by microsomal monooxygenase system in the liver. The effect of phenobarbital(PB) on the monooxygenase system in the... -
- CITED
-
- Close
- SHARE
-
- Close
