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Bioprospecting of Endophytic Fungi as Promising Anti-MRSA Agents

Wei YM, Tan JS, Tang HW, Tong WY, Leong CR, Tan WN

Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to the global healthcare system. Ineffective and resistance to antibiotic treatments have increased morbidity and mortality rates worldwide. New and effective antibiotics are...
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Feasibility of Loop-Mediated Isothermal Amplification for Rapid Detection of Methicillin-Susceptible and Methicillin-Resistant Staphylococcus aureus in Tissue Samples

Kim SG, Choi GW, Choi WS, Lim CS, Jang WS, Bae JH

Background: To date, few studies have investigated the feasibility of the loop-mediated isothermal amplification (LAMP) assay for identifying pathogens in tissue samples. This study aimed to investigate the feasibility of...
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Antibiotics for multidrug-resistant gram-positive bacteria

Song KH

Background: Antimicrobial resistance is a major global threat to public health and is associated with increased morbidity and mortality. A few therapeutic options for the treatment of multidrug resistant (MDR)...
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Current status of multidrug-resistant bacteria

Kim D, Jeong SH

Background: The dissemination of multidrug-resistant (MDR) pathogen is of major public health concern as it leads to increased mortality rate, length of hospital stays, and medical expenses. Current Concepts: Korean Government...
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Effects of Stepwise Application of Active Surveillance Culture, Preemptive Isolation, and Chlorhexidine Bed Bath on the Acquisition of Methicillin-resistant Staphylococcus aureus in Children Undergoing Cardiac Surgery in the Paediatric Intensive Care Unit

Cho SY, Jeong JS, Kim EO, Kim YH

Background: This study aimed to investigate the effects of stepwise strengthening of methicillinresistant Staphylococcus aureus (MRSA) infection control on the acquisition and identification of risk factors for acquiring MRSA in...
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Scalp Reconstruction and Cranioplasty using the Latissimus Dorsi Musculocutaneous Flap in a Patient with Recurrent Wound Dehiscence Accompanied by MRSA Infection

Yoon T, Kim SW

The latissimus dorsi flap has high vascularity and is helpful for the reconstruction of infected areas. Herein, we present a patient with recurrent infections and soft-tissue defects who underwent cranial...
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Urgent need for novel antibiotics in Republic of Korea to combat multidrug-resistant bacteria

Lee HJ, Lee DG

Multidrug resistance in bacteria is an important issue and is increasing in frequency worldwide because of the limitations of therapeutic agents. From 2010 to 2019, 14 new systemic antibiotics received...
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Clinical Efficacy and Safety of Arbekacin against Pneumonia in Febrile Neutropenia: A Retrospective Study in Patients with Hematologic Malignancies

Ohashi T, Fujita Y, Irisawa H, Nakaminami H, Arai T, Takahashi M, Momiyama E, Murata N, Murayama K, Saito T

Background: Arbekacin (ABK) is an aminoglycoside that exhibits anti-methicillin-resistant Staphylococcus aureus (MRSA) and anti-Pseudomonas aeruginosa activities. Therefore, for patients with febrile neutropenia (FN) and concurrent pneumonia suspected to be caused...
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Evaluation of copper alloys for reducing infection by methicillin resistant Staphylococcus aureus and vancomycin resistant Enterococcus faecium in intensive care unit and in vitro

Choi SI, Chang MS, Kim T, Chung KH, Bae S, Kim SH, Yoon CJ, Kim YK, Woo JH

Background/Aims: Multi-drug resistant pathogens are increasing among healthcare-associated infections. It is well known that copper and copper alloys have antimicrobial activity. We evaluated the activity of copper against bacteria in...
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Ten-Year Prevalence Trends of Phenotypically Identified Community-Associated Methicillin-Resistant Staphylococcus aureus Strains in Clinical Specimens

Yu SH, Lee JH, Kim MC, Choi SH, Chung JW, Lee MK

Background: Community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) strains were first detected in hospitals in Korea between the late 2000s and early 2010s. However, there is limited information regarding the prevalence of CA-MRSA...
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Outbreak of Neonatal Staphylococcal Scalded Skin Syndrome in a Maternal Unit

Jeon Y, Hwang Y, Park Y, Kim C, Lim R

Objective: Staphylococcal scalded skin syndrome (SSSS) is a relatively rare superficial blistering skin disease caused by exfoliating toxins produced by Staphylococcus aureus. We experienced a 3-month outbreak of neonatal...
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CD11b Deficiency Exacerbates Methicillin-Resistant Staphylococcus aureus-Induced Sepsis by Upregulating Inflammatory Responses of Macrophages

Sim H, Jeong D, Kim HI, Pak S, Thapa B, Kwon HJ, Lee K

Macrophages are important for the first line of defense against microbial pathogens. Integrin CD11b, which is encoded by Itgam, is expressed on the surface of macrophages and has been implicated...
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Linezolid Resistance in Methicillin-Resistant Staphylococcus aureus in Korea: High Rate of False Resistance to Linezolid by the VITEK 2 System

Yoo IY, Kang OK, Shim HJ, Huh HJ, Lee NY

As various linezolid resistance mechanisms have been identified in methicillin-resistant Staphylococcus aureus (MRSA), we investigated the molecular characteristics of MRSA with elevated linezolid minimum inhibitory concentrations (MICs), using the VITEK...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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Clinical Review of Staphylococcal Scalded Skin Syndrome in a Single Institution for 18 Years, 2001–2018

Lee SJ, Lee DW

Staphylococcal scalded skin syndrome (SSSS) is a disease caused by exfoliative toxin. The purpose of this study is to analyze clinical features, laboratory findings and treatment outcome of patients who...
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Molecular Epidemiologic Study of a Methicillin-resistant Staphylococcus aureus Outbreak at a Newborn Nursery and Neonatal Intensive Care Unit

Kang HM, Park KC, Lee KY, Park J, Park SH, Lee DG, Kim JH

PURPOSE: This study aimed to investigate the molecular epidemiology of a methicillin-resistant Staphylococcus aureus (MRSA) outbreak at a newborn nursery and neonatal intensive care unit (NICU). METHODS: During the outbreak, from...
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Changing Susceptibility of Staphylococcus aureus in Children with Skin and Soft Tissue Infections: a Single Center Experience from 2010 to 2018

Cho YS, Lee SH, Lee TJ

PURPOSE: Staphylococcus aureus is a major cause of skin and soft tissue infections (SSTIs). This study aimed to determine the temporal trends in antibiotic susceptibility of S. aureus in SSTI...
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Awareness and Competency of Multi-Drug Resistant Organisms Infection Control in Nursing Students with Clinical Practice

Ryu D, Ryu E

PURPOSE: The aim of this study was to identify awareness and competency for Multi-Drug Resistant Organisms (MDRO) infection control in nursing students with experience of clinical practice. METHODS: This cross-sectional descriptive...
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Methicillin-resistant Staphylococcus aureus screening is important for surgeons

Hyun IK, Park PJ, Park D, Choi SB, Han HJ, Song TJ, Jung CW, Kim WB

BACKGROUNDS/AIMS: Perioperative surgical site infection (SSI) remains a morbid complication even in successful surgical procedures. We encountered an unusual experience of a methicillin-resistant Staphylococcus aureus (MRSA)-related SSI outbreak in our...
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