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Pharmacological Treatment of Nonalcoholic Fatty Liver Disease: Antidiabetic Agents

Kim KS

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorders and is associated with various metabolic diseases, including type 2 diabetes mellitus (T2DM). There are no approved drugs for...
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Human Tissue-Engineered Skeletal Muscle: A Tool for Metabolic Research

Kim JH, Yu SM, Son JW

Skeletal muscle is now regarded as an endocrine organ based on its secretion of myokines and exerkines, which, in response to metabolic stimuli, regulate the crosstalk between the skeletal muscle...
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A review of recent evidence of dietary protein intake and health

Park YJ, Chung S, Hwang JT, Shon J, Kim E

The Korea National Health and Nutrition Examination Survey of 2013 to 2017 reported that the average protein consumption of the Korean population is above the current recommended nutrient intake of...
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Betulin Targets Lipin1/2-Meidated P2X7 Receptor as a Therapeutic Approach to Attenuate Lipid Accumulation and Metaflammation

Dou JY, Jiang YC, Hu ZH, Yao KC, Yuan MH, Bao XX, Zhou MJ, Liu Y, Li ZX, Lian LH, Nan JX, Wu YL

The present study focused on the potential mechanism of betulin (BT), a pentacyclic triterpenoid isolated from the bark of white birch (Betula pubescens), against chronic alcohol-induced lipid accumulation and metaflammation....
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Effects of interleukin-17 inhibitors on hepatic fibrosis index in patients with psoriasis and metabolic dysfunction-associated fatty liver disease: Directed acyclic graphs

Takamura S, Teraki Y, Katayama E, Kawaguchi T, Kawaguchi M, Nakano D, Tsutsumi T, Nagoshi S, Nakama T, Torimura T

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The Role of T Cells in Obesity-Associated Inflammation and Metabolic Disease

Park CS, Shastri N

Chronic inflammation plays a critical role in the development of obesity-associated metabolic disorders such as insulin resistance. Obesity alters the microenvironment of adipose tissue and the intestines from anti-inflammatory to...
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Bariatric surgery versus medical therapy in Korean obese patients: prospective multicenter nonrandomized controlled trial (KOBESS trial)

Park DJ, An S, Park YS, Lee JH, Lee HJ, Ha TK, Kim YJ, Ryu SW, Han SM, Yoo MW, Park S, Han SU, Kang JH, Kwon JW, Heo Y

Purpose: The aim of this study was to show that bariatric surgery (BS) is more effective than medical therapy (MT) in Asian obese patients. Methods: In this prospective, multicenter, nonrandomized, controlled...
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Is the Sleeve Gastrectomy Sufficient or Does it Require Additional Surgical Procedures?

Choi SI

Laparoscopic sleeve gastrectomy is a relatively simple procedure and has become the most well-known bariatric surgical procedure in Korea and Western countries. However, this procedure has several disadvantages in terms...
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Iron Reshapes the Gut Microbiome and Host Metabolism

Botta A, Barra NG, Lam NH, Chow S, Pantopoulos K, Schertzer JD, Sweeney G

Compelling studies have established that the gut microbiome is a modifier of metabolic health. Changes in the composition of the gut microbiome are influenced by genetics and the environment, including...
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Clinical and Histologic Features of Patients with Biopsy-Proven Metabolic Dysfunction-Associated Fatty Liver Disease

Huang SC, Su HJ, Kao JH, Tseng TC, Yang HC, Su TH, Chen PJ, Liu CJ

Background/Aims: Fatty liver disease is defined as a cluster of diseases with heterogeneous etiologies, and its definition continues to evolve. The novel conceptional criteria for metabolic dysfunction-associated fatty liver disease...
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The impacts of exercise on pediatric obesity

Headid III RJ, Park SY

Over the last few decades, the rates of pediatric obesity have more than doubled regardless of sociodemographic categorization, and despite these rates plateauing in recent years there continues to be...
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Effects of Exercise and a High-Fat, High-Sucrose Restriction Diet on Metabolic Indicators, Nr4a3, and Mitochondria-Associated Protein Expression in the Gastrocnemius Muscles of Mice with Diet-Induced Obesity

Lee JH, Zhang D, Kwak SE, Shin HE, Song W

Background: Exercise and high fat, high sucrose restriction diets are well known treatments for obesity. The aim of this study was to measure the effects of those lifestyle interventions on...
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Metabolic disease as a risk of hepatocellular carcinoma

Nishida N

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Gut Microbial Dysbiosis in the Pathogenesis of Gastrointestinal Dysmotility and Metabolic Disorders

Singh R, Zogg H, Wei L, Bartlett A, Ghoshal UC, Rajender S, Ro S

  • KMID: 2510059
  • J Neurogastroenterol Motil.
  • 2021 Jan;27(1):19-34.
  • doi: 10.5056/jnm20149
Of all microorganisms in the human body, the largest and most complex population resides in the gastrointestinal (GI) tract. The gut microbiota continuously adapts to the host environment and serves...
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Early menarche and its consequence in Korean female: reducing fructose intake could be one solution

Kim JH, Lim JS

The mean age at menarche (AAM) of Korean females has been rapidly decreasing over the last 50 years; currently, the prevalence of early menarche (
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Vitamin D regulation of adipogenesis and adipose tissue functions

Nimitphong H, Park E, Lee MJ

Vitamin D insufficiency is associated with obesity and its related metabolic diseases. Adipose tissues store and metabolize vitamin D and expression levels of vitamin D metabolizing enzymes are known to...
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Sedentary Lifestyle: Overview of Updated Evidence of Potential Health Risks

Park JH, Moon JH, Kim HJ, Kong MH, Oh YH

One-third of the global population aged 15 years and older engages in insufficient physical activities, which affects health. However, the health risks posed by sedentary behaviors are not well known....
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Beneficial effect of anti-diabetic drugs for nonalcoholic fatty liver disease

Kim KS, Lee BW

Nonalcoholic fatty liver disease (NAFLD) is the most common liver disorder and is associated with various metabolic diseases, including type 2 diabetes mellitus. There are no approved drugs for NAFLD,...
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Revisiting the Bacterial Phylum Composition in Metabolic Diseases Focused on Host Energy Metabolism

Lee Y, Lee HY

Over a hundred billion bacteria are found in human intestines. This has emerged as an environmental factor in metabolic diseases, such as obesity and related diseases. The majority of these...
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Sex-, Age-, and Metabolic Disorder-Dependent Distributions of Selected Inflammatory Biomarkers among Community-Dwelling Adults

Cho SMJ, Lee H, Shim JS, Kim HC

Background Inflammatory cytokines are increasingly utilized to detect high-risk individuals for cardiometabolic diseases. However, with large population and assay methodological heterogeneity, no clear reference currently exists. Methods Among participants of the Cardiovascular and...
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