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MiR-484 Protects Rat Myocardial Cells from Ischemia-Reperfusion Injury by Inhibiting Caspase-3 and Caspase-9 during Apoptosis

Liu H, Li S, Jiang W, Li Y

BACKGROUND AND OBJECTIVES: To reveal the detail mechanism of miR-484 on myocardial ischemia-reperfusion (MI/R) injury. METHODS: Rats model of MI/R injury was established based on control (Con; sham operate) group, ischemia-reperfusion...
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Decreased inward rectifier and voltage-gated K⁺ currents of the right septal coronary artery smooth muscle cells in pulmonary arterial hypertensive rats

Kim SE, Yin MZ, Kim HJ, Vorn R, Yoo HY, Kim SJ

In vascular smooth muscle, K⁺ channels, such as voltage-gated K⁺ channels (Kv), inward-rectifier K⁺ channels (Kir), and big-conductance Ca²⁺-activated K⁺ channels (BK(Ca)), establish a hyperpolarized membrane potential and counterbalance the...
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Involvement of a Novel Organic Cation Transporter in Paeonol Transport Across the Blood-Brain Barrier

Gyawali A, Krol S, Kang YS

Paeonol has neuroprotective function, which could be useful for improving central nervous system disorder. The purpose of this study was to characterize the functional mechanism involved in brain transport of...
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Control of Motility in the Internal Anal Sphincter

Keef KD, Cobine CA

  • KMID: 2449091
  • J Neurogastroenterol Motil.
  • 2019 Apr;25(2):189-204.
  • doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During...
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Development of Artificial Intelligence to Support Needle Electromyography Diagnostic Analysis

Nam S, Sohn MK, Kim HA, Kong HJ, Jung IY

OBJECTIVES: This study proposes a method for classifying three types of resting membrane potential signals obtained as images through diagnostic needle electromyography (EMG) using TensorFlow-Slim and Python to implement an...
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A physiology based model of heart rate variability

von Rosenberg W, Hoting MO, Mandic DP

Heart rate variability (HRV) is governed by the autonomic nervous system (ANS) and is routinely used to estimate the state of body and mind. At the same time, recorded HRV...
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Rejuvenating Aged Hematopoietic Stem Cells Through Improvement of Mitochondrial Function

Moon J, Kim HR, Shin MG

Mitochondria are the powerhouses of the cell as well as the primary site of hematopoiesis, which also occurs in the cytoplasm. Hematopoietic stem cells (HSCs) are characterized by a very...
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Comparison of electrophysiological properties of two types of pre-sympathetic neurons intermingled in the hypothalamic paraventricular nucleus

Shen Y, Han SK, Ryu PD

The hypothalamic paraventricular nucleus (PVN) contains two types of neurons projecting to either the rostral ventrolateral medulla (PVN(RVLM)) or the intermediolateral horn (IML) of the spinal cord (PVN(IML)). These two...
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Nobiletin attenuates neurotoxic mitochondrial calcium overload through K⁺ influx and ΔΨ(m) across mitochondrial inner membrane

Lee JH, Amarsanaa , Wu J, Jeon SC, Cui Y, Jung SC, Park DB, Kim SJ, Han SH, Kim HW, Rhyu IJ, Eun SY

Mitochondrial calcium overload is a crucial event in determining the fate of neuronal cell survival and death, implicated in pathogenesis of neurodegenerative diseases. One of the driving forces of calcium...
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Mitochondrial dysfunction reduces the activity of KIR2.1 K⁺ channel in myoblasts via impaired oxidative phosphorylation

Woo J, Kim HJ, Nam YR, Kim YK, Lee EJ, Choi I, Kim SJ, Lee W, Nam JH

Myoblast fusion depends on mitochondrial integrity and intracellular Ca²⁺ signaling regulated by various ion channels. In this study, we investigated the ionic currents associated with [Ca²⁺]i regulation in normal and...
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Electrophysiological characteristics of R47W and A298T mutations in CLC-1 of myotonia congenita patients and evaluation of clinical features

Chin HJ, Kim CH, Ha K, Shin JH, Kim DS, So I

Myotonia congenita (MC) is a genetic disease that displays impaired relaxation of skeletal muscle and muscle hypertrophy. This disease is mainly caused by mutations of CLCN1 that encodes human skeletal...
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Action of Mitochondrial Substrates on Neuronal Excitability in Rat Substantia Gelatinosa Neurons

Lee HI, Chun SW

Recent studies indicate that mitochondria are an important source of reactive oxygen species (ROS) in the spinal dorsal horn. In our previous study, application of malate, a mitochondrial electron transport...
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miR-24-mediated knockdown of H2AX damages mitochondria and the insulin signaling pathway

Jeong JH, Cheol Kang Y, Piao Y, Kang S, Pak YK

Mitochondrial deficits or altered expressions of microRNAs are associated with the pathogenesis of various diseases, and microRNA-operated control of mitochondrial activity has been reported. Using a retrovirus-mediated short-hairpin RNA (shRNA)...
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Transcranial Direct Current Stimulation as an Alternative Treatment in Patients with Alzheimer's Disease

Kim YJ

Transcranial direct current stimulation (tDCS) is one of the brain stimulation techniques, which considered as an alternative treatment for Alzheimer's disease (AD). In AD, cognitive, behavior, and functional deteriorations are...
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Passage-dependent expression of inward rectifying potassium current in human umbilical cord vein-derived mesenchymal stem cells

Park KS, Chai YG, Kim Y

Although stem cells are used as important cell therapies in regenerative medicine, the electrophysiological problems that arise in the expansion of cells have not been known much. This study was...
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Intracellular calcium-dependent regulation of the sperm-specific calcium-activated potassium channel, hSlo3, by the BK(Ca) activator LDD175

Wijerathne TD, Kim J, Yang D, Lee KP

Plasma membrane hyperpolarization associated with activation of Ca²⁺-activated K⁺ channels plays an important role in sperm capacitation during fertilization. Although Slo3 (slowpoke homologue 3), together with the auxiliary γ2-subunit, LRRC52...
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Slow Wave Activity and Modulations in Mouse Jejunum Myenteric Plexus In Situ

Cai Y, Tang H, Jiang F, Dong Z

  • KMID: 2367463
  • J Neurogastroenterol Motil.
  • 2017 Jan;23(1):117-123.
  • doi: 10.5056/jnm16012
BACKGROUND/AIMS: Myenteric plexus interstitial cells of Cajal (ICC-MY) are involved in the generation of gut pacemaker activity and neuronal communication. We performed patch clamp on ICC-MY in situ to observe...
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DAMGO modulates two-pore domain K⁺ channels in the substantia gelatinosa neurons of rat spinal cord

Cho PS, Lee HK, Lee SH, Im JZ, Jung SJ

The analgesic mechanism of opioids is known to decrease the excitability of substantia gelatinosa (SG) neurons receiving the synaptic inputs from primary nociceptive afferent fiber by increasing inwardly rectifying K⁺...
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Mitochondrial pyruvate dehydrogenase phosphatase 1 regulates the early differentiation of cardiomyocytes from mouse embryonic stem cells

Heo HJ, Kim HK, Youm JB, Cho SW, Song IS, Lee SY, Ko TH, Kim N, Ko KS, Rhee BD, Han J

Mitochondria are crucial for maintaining the properties of embryonic stem cells (ESCs) and for regulating their subsequent differentiation into diverse cell lineages, including cardiomyocytes. However, mitochondrial regulators that manage the...
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Effects of analgesics and antidepressants on TREK-2 and TRESK currents

Park H, Kim EJ, Han J, Han J, Kang D

TWIK-related K+ channel-2 (TREK-2) and TWIK-related spinal cord K+ (TRESK) channel are members of two-pore domain K+ channel family. They are well expressed and help to set the resting membrane...
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