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Trichinella Infection Ameliorated Vincristine-Induced Neuroinflammation in Mice

Jo YR, Park HT, Yu HS, Kong HH

Vincristine (VCR) is a chemotherapeutic agent widely used in treatment of malignancies. However, VCR has a limitation in use since it commonly causes a painful neuropathy (VCR-induced peripheral neuropathy, VIPN)....
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The anti-nociceptive effect of BPC-157 on the incisional pain model in rats

Jung YH, Kim H, Kim H, Kim E, Baik J, Kang H

Background: The pentadecapeptide BPC-157 has been shown to have anti-inflammatory and wound healing effects on multiple target tissues and organs. Peptides have potent anti-inflammatory effects on periodontal tissues in rats...
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Glial Cell Line-derived Neurotrophic Factor-overexpressing Human Neural Stem/Progenitor Cells Enhance Therapeutic Efficiency in Rat with Traumatic Spinal Cord Injury

Hwang K, Jung K, Kim IS, Kim M, Han J, Lim J, Shin JE, Jang JH, Park KI

Spinal cord injury (SCI) causes axonal damage and demyelination, neural cell death, and comprehensive tissue loss, resulting in devastating neurological dysfunction. Neural stem/progenitor cell (NSPCs) transplantation provides therapeutic benefits for...
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Preemptive application of QX-314 attenuates trigeminal neuropathic mechanical allodynia in rats

Yoon JH, Son JY, Kim MJ, Kang SH, Ju JS, Bae YC, Ahn DK

The aim of the present study was to examine the effects of preemptive analgesia on the development of trigeminal neuropathic pain. For this purpose, mechanical allodynia was evaluated in male...
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Allopregnanolone suppresses mechanical allodynia and internalization of neurokinin-1 receptors at the spinal dorsal horn in a rat postoperative pain model

Fujita M, Fukuda T, Sato Y, Takasusuki T, Tanaka M

BACKGROUND: To identify a new strategy for postoperative pain management, we investigated the analgesic effects of allopregnanolone (Allo) in an incisional pain model, and also assessed its effects on the...
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The efficacy of combination treatment of gabapentin and electro-acupuncture on paclitaxel-induced neuropathic pain

Kim MJ, Lee JH, Jang JU, Quan FS, Kim SK, Kim W

Paclitaxel, a chemotherapeutic drug, induces severe peripheral neuropathy. Gabapentin (GBT) is a first line agent used to treat neuropathic pain, and its effect is mediated by spinal noradrenergic and muscarinic...
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Intravenous Administration of Substance P Attenuates Mechanical Allodynia Following Nerve Injury by Regulating Neuropathic Pain-Related Factors

Chung E, Yoon TG, Kim S, Kang M, Kim HJ, Son Y

This study aimed to investigate the analgesic effect of substance P (SP) in an animal model of neuropathic pain. An experimental model of neuropathic pain, the chronic constriction injury (CCI)...
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Participation of central GABAA receptors in the trigeminal processing of mechanical allodynia in rats

Kim MJ, Park YH, Yang KY, Ju JS, Bae YC, Han SK, Ahn DK

Here we investigated the central processing mechanisms of mechanical allodynia and found a direct excitatory link with low-threshold input to nociceptive neurons. Experiments were performed on male Sprague-Dawley rats weighing...
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Differential Role of Central GABA Receptors in Nociception of Orofacial Area in Rats

Lee AR, Lim NH, Kim HJ, Kim MJ, Ju JS, Park MK, Lee MK, Yang KY, Ahn DK

The present study investigated the role of central GABA(A) and GABA(B) receptors in orofacial pain in rats. Experiments were conducted on Sprague-Dawley rats weighing between 230 and 280 g. Intracisternal...
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Mechanical Antiallodynic Effect of Intrathecal Nefopam in a Rat Neuropathic Pain Model

Kim KH, Byeon GJ, Kim HY, Baek SH, Shin SW, Koo ST

Nefopam has a pharmacologic profile distinct from that of opioids or other anti-inflammatory drugs. Several recent studies demonstrate that nefopam has a mechanism of action similar to those of anti-depressants...
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Olanzapine Attenuates Mechanical Allodynia in a Rat Model of Partial Sciatic Nerve Ligation

Fukuda T, Yamashita , Hisano S, Tanaka M

BACKGROUND: Neuropathic pain is a global clinical problem; nevertheless, nerve injury treatment methods remain limited. Olanzapine has antinociceptive and anti-nueropathic properties; however, its preventive effects have not been assessed in...
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Effect of superoxide on the development and maintenance of mechanical allodynia in a rat model of chronic post-ischemia pain

Han CG, Han JK, Park KB, Kwak KH, Park SS, Lim DG

BACKGROUND: Reactive oxygen species and inflammatory responses contribute to the development of neuropathic pain. Superoxide serves to mediate cell signaling processes and tissue injury during inflammation. We examined the effects...
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Gender differences in paclitaxel-induced neuropathic pain behavior and analgesic response in rats

Hwang BY, Kim ES, Kim CH, Kwon JY, Kim HK

BACKGROUND: Females show greater sensitivity than males to several modalities of experimental pain. However, the gender differences in paclitaxel-induced neuropathic pain have not been studied. The current study examined the...
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The Long-Lasting Pattern of the Neuropathic Radicular Pain in An Autologous Nucleus Pulposus Model of Rat

Kim WR, Ahn SH, Cho YW, Cho HK, Kim HS, Kim SJ, Seo JM

  • KMID: 2325478
  • J Korean Acad Rehabil Med.
  • 2009 Aug;33(4):477-482.
OBJECTIVE: To observe the long-lasting changes of pain progression with time course in an autologous nucleus pulposus model of rat. METHOD: The subjects were 25 Sprague-Dawley (Sprague- Dawley, 250 gm) male...
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Long-term Follow-up of Cutaneous Hypersensitivity in Rats with a Spinal Cord Contusion

Jung JI, Kim J, Hong SK, Yoon YW

Sometimes, spinal cord injury (SCI) results in various chronic neuropathic pain syndromes that occur diffusely below the level of the injury. It has been reported that behavioral signs of neuropathic...
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Behavioral Manifestation of Neuropathic Pain Following Sciatic Nerve Section in Rats

Yoo DJ, Na HS, Yoon YW

The present study was performed to observe the time course of behavioral signs of painful sensations in sciatic neurectomy animal model and to test the effects of sympathectomy and saphenous...
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The Expression of alpha2-Adrenergic Receptor Subtypes in the Central Nervous System of Peripheral Nerve Injured Rats

Choi SR, Lee HC, Chung CJ, Kim HK

BACKGROUND: The change of expression of the alpha2-adrenergic receptor (alpha(2)-AR) subtypes in the thalamus and hypothalamus were investigated in a neuropathic pain rat model. METHODS: The left sciatic nerve was clamped...
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Clinical Features of Central Neuropathic Pain after Contusive Spinal Cord Injury in Rats

Lee SY, Im HL, Kim JH, Jung SH, Choi IS, Lee SG

  • KMID: 1810946
  • J Korean Acad Rehabil Med.
  • 2006 Apr;30(2):142-147.
OBJECTIVE: To investigate the characteristics of the central neuropathic pain (CNP) after contusive spinal cord injury in rats. METHOD: Twenty Sprague-Dawley rats (300+/-50 g, male) undergone the free-drop contusion injury from...
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The Effect of alpha2 Adrenergic Agonists and Norepinephrine on Mechanical Allodynia by Freund's Complete Adjuvant Induced Inflammation in Rats

Cheong MA, Kim HN, Jun JH, Kim KH, Suh JK, Hwang JH, Park PH, Key WY

BACKGROUND: The Freund's complete adjuvant (FCA)-induced inflammation may produce allodynia against a touch stimulus. The antiallodynic effects of brimonidine, a new selective alpha2 receptor agonist, and of rilmenidine, a new...
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The Effect of Intradermal Norepinephrine on Allodynia in a Neuropathic Pain Rat Model

Hwang JH, Choi DK, Kang HJ, Kim YK, Park JY

BACKGROUND: A spinal nerve ligation (SNL) injury may produce a neuropathic pain syndrome that includes tactile allodynia. This pain state may be diminished by sympathectomy. Intradermal (I.D.) injection...
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