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Deep Tissue Clearing for Three-dimensional Imaging Analysis of Murine Pancreas

Mali NM, Park JM, Kim GH, Choi DH, Ramos R, Lee JH, Ku EJ, Oh JW

Optical imaging of the vascular system is necessary for structural, functional, developmental, and pathological biology. Recent developments in optical tissue-clearing methods have significantly advanced large-scale tissue researches by integrating a...
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Restoration of Immune Privilege in Human Dermal Papillae Controlling Epithelial-Mesenchymal Interactions in Hair Formation

Park JM, Jun MS, Kim JA, Mali NM, Hsi TC, Cho A, Kim JC, Kim JY, Seo I, Kim J, Kim M, Oh JW

BACKGROUND: Hair follicles are among a handful of organs that exhibit immune privilege. Dysfunction of the hair follicle immune system underlies the development of inflammatory diseases, such as alopecia areata. METHODS:...
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Asymmetric Contribution of Blastomere Lineages of First Division of the Zygote to Entire Human Body Using Post-Zygotic Variants

Kwon SG, Bae GH, Choi JH, Mali NM, Jun MS, Kim DS, Han MH, Park S, Ju YS, Choi SH, Oh JW

BACKGROUND: In humans, after fertilization, the zygote divides into two 2n diploid daughter blastomeres. During this division, DNA is replicated, and the remaining mutually exclusive genetic mutations in the genome...
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