- Differential Activation of Macrophages Based on Their Environment in Advanced Age
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Lee DY, Lim JS, Cho KA
- KMID: 2468141
- Chonnam Med J.
- 2020 Jan;56(1):12-19.
- doi: 10.4068/cmj.2020.56.1.12
The macrophage displays functional and phenotypic diversity, which appears, in no small part, to stem from the ability of macrophages to adapt functionally to changes in their tissue microenvironment. Here,... -
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- Perivascular Stem Cells Suppress Inflammasome Activation during Inflammatory Responses in Macrophages
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Kim J, Kim WJ, Ha KS, Han ET, Park WS, Yang SR, Hong SH
- KMID: 2465882
- Int J Stem Cells.
- 2019 Nov;12(3):419-429.
- doi: 10.15283/ijsc19115
BACKGROUND AND OBJECTIVES: Perivascular stem cells (PVCs) have been identified as precursors of mesenchymal stem cells (MSCs) that offer promising prospects for application in the development of cellular therapies. Although... -
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- Rhodanthpyrone A and B play an anti-inflammatory role by suppressing the nuclear factor-κB pathway in macrophages
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Kim KS, Han CY, Han YT, Bae EJ
- KMID: 2461042
- Korean J Physiol Pharmacol.
- 2019 Nov;23(6):493-499.
- doi: 10.4196/kjpp.2019.23.6.493
Macrophage-associated inflammation is crucial for the pathogenesis of diverse diseases including metabolic disorders. Rhodanthpyrone (Rho) is an active component of Gentiana rhodantha, which has been used in traditional Chinese medicine... -
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- Two Distinct Subsets Are Identified from the Peritoneal Myeloid Mononuclear Cells Expressing both CD11c and CD115
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Sohn M, Na HY, Ryu SH, Choi W, In H, Shin HS, Park JS, Shim D, Shin SJ, Park CG
- KMID: 2450200
- Immune Netw.
- 2019 Jun;19(3):e15.
- doi: 10.4110/in.2019.19.e15
To this date, the criteria to distinguish peritoneal macrophages and dendritic cells (DCs) are not clear. Here we delineate the subsets of myeloid mononuclear cells in the mouse peritoneal cavity.... -
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- ZFP36L1 and AUF1 Induction Contribute to the Suppression of Inflammatory Mediators Expression by Globular Adiponectin via Autophagy Induction in Macrophages
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Shrestha A, Pun NT, Park PH
- KMID: 2421722
- Biomol Ther.
- 2018 Sep;26(5):446-457.
- doi: 10.4062/biomolther.2018.078
Adiponectin, a hormone predominantly originated from adipose tissue, has exhibited potent anti-inflammatory properties. Accumulating evidence suggests that autophagy induction plays a crucial role in anti-inflammatory responses by adiponectin. However, underlying... -
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- LPS-stimulated Macrophage Activation Affects Endothelial Dysfunction
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Baek N, Sim S, Heo KS
- KMID: 2409051
- J Bacteriol Virol.
- 2018 Mar;48(1):23-30.
- doi: 10.4167/jbv.2018.48.1.23
Intestinal microbiota is involved in the atherosclerotic process by development of an atheromatous core with foam cells in carotid arteries. It has reported that lipopolysaccharide (LPS) from Escherichia coli localizes... -
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- The Preventive and Curative Effect of Cyanidin-3β-D-Glycoside and Its Metabolite Protocatechuic Acid Against TNBS-induced Colitis in Mice
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Jang SE, Choi JR, Han MJ, Kim DH
- KMID: 2366697
- Nat Prod Sci.
- 2016 Dec;22(4):282-286.
- doi: 10.20307/nps.2016.22.4.282
Cyanidin-3β-D-glycoside (C3G), which is widely distributed in herbal medicines and functional foods, exhibits anti-inflammatory, anti-oxidant, and anti-scratching behavioral effects. Orally administered C3G is metabolized to protocatechuic acid (PA) by gut... -
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- A New Triggering Receptor Expressed on Myeloid Cells (TREM) Family Member, TLT-6, is Involved in Activation and Proliferation of Macrophages
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Won KJ, Park SW, Lee S, Kong IK, Chae JI, Kim B, Lee EJ, Kim DK
- KMID: 2150852
- Immune Netw.
- 2015 Oct;15(5):232-240.
- doi: 10.4110/in.2015.15.5.232
The triggering receptor expressed on myeloid cells (TREM) family, which is abundantly expressed in myeloid lineage cells, plays a pivotal role in innate and adaptive immune response. In this study,... -
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- MyD88-BLT2-dependent cascade contributes to LPS-induced interleukin-6 production in mouse macrophage
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Lee AJ, Cho KJ, Kim JH
- KMID: 2070275
- Exp Mol Med.
- 2015 Apr;47(4):e156.
- doi: 10.1038/emm.2015.8
Endotoxic responses to bacterial lipopolysaccharide (LPS) are triggered by Toll-like receptor 4 (TLR4) and involve the production of inflammatory mediators, including interleukin-6 (IL-6), by macrophages. The detailed mechanism of IL-6... -
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- Therapeutic Effects of S-Petasin on Disease Models of Asthma and Peritonitis
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Lee KP, Kang S, Noh MS, Park SJ, Kim JM, Chung HY, Je NK, Lee YG, Choi YW, Im DS
- KMID: 2380362
- Biomol Ther.
- 2015 Jan;23(1):45-52.
- doi: 10.4062/biomolther.2014.069
To explore the anti-allergic and anti-inflammatory effects of extracts of Petasites genus, we studied the effects of s-petasin, a major sesquiterpene from Petasites formosanus (a butterbur species) on asthma and... -
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- IL-33 Priming Enhances Peritoneal Macrophage Activity in Response to Candida albicans
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Tran VG, Cho HR, Kwon B
- KMID: 2150808
- Immune Netw.
- 2014 Aug;14(4):201-206.
- doi: 10.4110/in.2014.14.4.201
IL-33 is a member of the IL-1 cytokine family and plays a role in the host defense against bacteria, viruses, and fungi. In this study, we investigated the function of... -
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- Dimethyl Sulfoxide Suppresses Mouse 4T1 Breast Cancer Growth by Modulating Tumor-Associated Macrophage Differentiation
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Deng R, Wang SM, Yin T, Ye TH, Shen GB, Li L, Zhao JY, Sang YX, Duan XG, Wei YQ
- KMID: 2353080
- J Breast Cancer.
- 2014 Mar;17(1):25-32.
PURPOSE: The universal organic solvent dimethyl sulfoxide (DMSO) can be used as a differentiation inducer of many cancer cells and has been widely used as a solvent in laboratories. However,... -
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- Metformin Down-regulates TNF-alpha Secretion via Suppression of Scavenger Receptors in Macrophages
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Hyun B, Shin S, Lee A, Lee S, Song Y, Ha NJ, Cho KH, Kim K
- KMID: 2150777
- Immune Netw.
- 2013 Aug;13(4):123-132.
- doi: 10.4110/in.2013.13.4.123
Obesity is consistently increasing in prevalence and can trigger insulin resistance and type 2 diabetes. Many lines of evidence have shown that macrophages play a major role in inflammation associated... -
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- Immuno-enhancing Effects of Lactobacillus salivarius JWS 58 and Lactobacillus plantarum JWS 1354 isolated from duck
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Choi HJ, Kim JY, Shin MS, Lee SM, Lee WK
- KMID: 2307899
- Korean J Vet Res.
- 2011 Dec;51(4):281-288.
Lactobacillus salivarius JWS 58 (JWS 58) and Lactobacillus plantarum JWS 1354 (JWS 1354) are isolated from duck intestine and have ability to produce bacteriocin. The objective of this study was... -
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- Use of In Vivo and In Vitro Systems to Select Leishmania amazonensis Expressing Green Fluorescent Protein
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Costa SD, de Assis Golim M, Rossi-Bergmann B, Costa FT, Giorgio S
- KMID: 1715740
- Korean J Parasitol.
- 2011 Dec;49(4):357-364.
- doi: 10.3347/kjp.2011.49.4.357
Various Leishmania species were engineered with green fluorescent protein (GFP) using episomal vectors that encoded an antibiotic resistance gene, such as aminoglycoside geneticin sulphate (G418). Most reports of GFP-Leishmania have... -
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- Biodynamic parameters of micellar diminazene in sheep erythrocytes and blood plasma
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Staroverov SA, Sidorkin V, Fomin AS, Shchyogolev SY, Dykman LA
- KMID: 1365012
- J Vet Sci.
- 2011 Dec;12(4):303-307.
- doi: 10.4142/jvs.2011.12.4.303
In this work, we used a preparation of diminazene, which belongs to the group of aromatic diamidines. This compound acts on the causative agents of blood protozoan diseases produced by... -
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- Recombinant TAT-CD137 Ligand Cytoplasmic Domain Fusion Protein Induces the Production of IL-6 and TNF-alpha in Peritoneal Macrophages
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Kim JD, Lee EA, Quang NN, Cho HR, Kwon B
- KMID: 1449813
- Immune Netw.
- 2011 Aug;11(4):216-222.
- doi: 10.4110/in.2011.11.4.216
BACKGROUND: The ligand for CD137 (CD137L; also called 4-1BBL) is mainly expressed on activated APCs such as dendritic cells, B cells and macrophages. Even though CD137L functions as a trigger... -
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- The Macrophage-Specific Transcription Factor Can Be Modified Posttranslationally by Ubiquitination in the Lipopolysaccharide-Treated Macrophages
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Jung JW, Choi JC, Kim JY, Park IW, Choi BW, Shin JW, Christman
- KMID: 1442860
- Tuberc Respir Dis.
- 2011 Feb;70(2):113-124.
- doi: 10.4046/trd.2011.70.2.113
BACKGROUND: Macrophages are one of the most important inflammatory cells in innate immunity. PU.1 is a macrophage-specific transcription factor. Ubiquitins are the ultimate regulator of eukaryotic transcription. The ubiquitination process... -
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- Immunoregulation of Murine Immunocytes to Bifidobacteria Strain Isolated from Feces of Healthy Korean Children: IL-10 Release and Proportional Change of CD4+CD25+ Cells
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Jin D, Kim BW, Cho HC, Yoon SS, Park YS, Kim SK
- KMID: 2168581
- J Bacteriol Virol.
- 2010 Dec;40(4):171-177.
- doi: 10.4167/jbv.2010.40.4.171
Bifidobacteria is one of the prototypes of probiotics bacteria, normally inhabitating the intestinal tract of humans. To search for a potent immunoregulatory Bifidobacteria strain, we screened the Bifidobacteria strains isolated... -
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- Legionella lipoprotein activates toll-like receptor 2 and induces cytokine production and expression of costimulatory molecules in peritoneal macrophages
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Shim HK, Kim JY, Kim MJ, Sim HS, Park DW, Sohn JW, Kim MJ
- KMID: 1009390
- Exp Mol Med.
- 2009 Oct;41(10):687-694.
- doi: 10.3858/emm.2009.41.10.075
Legionella bacterium, an intracellular pathogen of mononuclear phagocytes, causes acute fatal pneumonia, especially in patients with impaired cellular immune responses. Until recently, however, the toll-like receptor (TLR) engagement of bacterial... -
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