- Strain Differences in the Chronic Mild Stress Animal Model of Depression and Anxiety in Mice
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Jung YH, Hong SI, Ma SX, Hwang JY, Kim JS, Lee JH, Seo JY, Lee SY, Jang CG
- KMID: 2380324
- Biomol Ther.
- 2014 Sep;22(5):453-459.
- doi: 10.4062/biomolther.2014.058
Chronic mild stress (CMS) has been reported to induce an anhedonic-like state in mice that resembles some of the symptoms of human depression. In the present study, we used a... -
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- Abuse Potential of Synthetic Cannabinoids: AM-1248, CB-13, and PB-22
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Hur KH, Ma SX, Lee BR, Ko YH, Seo JY, Ryu HW, Kim HJ, Yoon S, Lee YS, Lee SY, Jang CG
- KMID: 2517156
- Biomol Ther.
- 2021 Jul;29(4):384-391.
- doi: 10.4062/biomolther.2020.212
Currently, the expanding recreational use of synthetic cannabinoids (SCBs) threatens public health. SCBs produce psychoactive effects similar to those of tetrahydrocannabinol, the main component of cannabis, and additionally induce unexpected... -
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- Inhibitory Effects of Eucommia ulmoides Oliv. Bark on Scopolamine-Induced Learning and Memory Deficits in Mice
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Kwon SH, Ma SX, Joo HJ, Lee SY, Jang CG
- KMID: 2170664
- Biomol Ther.
- 2013 Nov;21(6):462-469.
Eucommia ulmoides Oliv. Bark (EUE) is commonly used for the treatment of hypertension, rheumatoid arthritis, lumbago, and ischialgia as well as to promote longevity. In this study, we tested the... -
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- Quinpirole Increases Melatonin-Augmented Pentobarbital Sleep via Cortical ERK, p38 MAPK, and PKC in Mice
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Hong SI, Kwon SH, Hwang JY, Ma SX, Seo JY, Ko YH, Kim HC, Lee SY, Jang CG
- KMID: 2170522
- Biomol Ther.
- 2016 Mar;24(2):115-122.
- doi: 10.4062/biomolther.2015.097
Sleep, which is an essential part of human life, is modulated by neurotransmitter systems, including gamma-aminobutyric acid (GABA) and dopamine signaling. However, the mechanisms that initiate and maintain sleep remain... -
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- The Anti-Inflammatory Activity of Eucommia ulmoides Oliv. Bark. Involves NF-κB Suppression and Nrf2-Dependent HO-1 Induction in BV-2 Microglial Cells
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Kwon SH, Ma SX, Hwang JY, Ko YH, Seo JY, Lee BR, Lee SY, Jang CG
- KMID: 2164219
- Biomol Ther.
- 2016 May;24(3):268-282.
- doi: 10.4062/biomolther.2015.150
In the present study, we investigated the anti-inflammatory properties of Eucommia ulmoides Oliv. Bark. (EUE) in lipopolysaccharide (LPS)-stimulated microglial BV-2 cells and found that EUE inhibited LPS-mediated up-regulation of pro-inflammatory... -
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- Vaccinium bracteatum Thunb. Exerts Anti-Inflammatory Activity by Inhibiting NF-κB Activation in BV-2 Microglial Cells
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Kwon SH, Ma SX, Ko YH, Seo JY, Lee BR, Lee TH, Kim SY, Lee SY, Jang CG
- KMID: 2351680
- Biomol Ther.
- 2016 Sep;24(5):543-551.
- doi: 10.4062/biomolther.2015.205
This study was designed to evaluate the pharmacological effects of Vaccinium bracteatum Thunb. methanol extract (VBME) on microglial activation and to identify the underlying mechanisms of action of these effects.... -
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