- Fucoidan Induces Apoptosis in A2058 Cells through ROS-exposed Activation of MAPKs Signaling Pathway
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Ryu YS, Hyun JW, Chung HS
- KMID: 2507448
- Nat Prod Sci.
- 2020 Sep;26(3):191-199.
- doi: 10.20307/nps.2020.26.3.191
Fucoidan, a natural component of brown seaweed, has various biological activities such as anticancer activity, anti-oxidant, and anti-inflammatory against various cancer cells. However, the fucoidan has been implicated in melanoma... -
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- Eupatilin downregulates phorbol 12-myristate 13-acetate-induced MUC5AC expression via inhibition of p38/ERK/JNK MAPKs signal pathway in human airway epithelial cells
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Cheon YH, Kim MS, Kim JY, Kim DH, Han SY, Lee JH
- KMID: 2471037
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):157-163.
- doi: 10.4196/kjpp.2020.24.2.157
Chronic inflammatory airway diseases, such as chronic rhinosinusitis, chronic obstructive pulmonary disease, and asthma, are associated with excessive mucus production. Hence, the regulation of mucus production is important for the... -
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- Transduced Tat-aldose Reductase Protects Hippocampal Neuronal Cells against Oxidative Stress-induced Damage
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Cho SB, Eum WS, Shin MJ, Kwon HJ, Park JH, Choi YJ, Park J, Han KH, Kang JH, Kim DS, Cho SW, Kim DW, Choi SY
- KMID: 2463716
- Exp Neurobiol.
- 2019 Oct;28(5):612-627.
- doi: 10.5607/en.2019.28.5.612
Aldose reductase (AR) protein, a member of the NADPH-dependent aldo-keto reductase family, reduces a wide range of aldehydes and enhances cell survival by inhibition of oxidative stress. Oxidative stress is... -
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- Immunomodulating activity of Sargassum horneri extracts in RAW264.7 macrophages
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Kim DS, Sung NY, Park SY, Kim G, Eom J, Yoo JG, Seo IR, Han IJ, Cho YB, Kim KA
- KMID: 2455839
- J Nutr Health.
- 2018 Dec;51(6):507-514.
- doi: 10.4163/jnh.2018.51.6.507
PURPOSE: Sargassum horneri (S. horneri) is a species of brown macroalgae that is common along the coast of Japan and Korea. The present study investigated the immuno-modulatory effects of different... -
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- Role of mitogen-activated protein kinases and nuclear factor-kappa B in 1,3-dichloro-2-propanol-induced hepatic injury
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Lee IC, Lee SM, Ko JW, Park SH, Shin IS, Moon C, Kim SH, Kim JC
- KMID: 2312151
- Lab Anim Res.
- 2016 Mar;32(1):24-33.
- doi: 10.5625/lar.2016.32.1.24
In this study, the potential hepatotoxicity of 1,3-dichloro-2-propanol and its hepatotoxic mechanisms in rats was investigated. The test chemical was administered orally to male rats at 0, 27.5, 55, and... -
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- Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-kappaB Pathways
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Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC
- KMID: 2380352
- Biomol Ther.
- 2015 Mar;23(2):180-188.
- doi: 10.4062/biomolther.2014.126
This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines... -
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- Characterization of Proinflammatory Responses and Innate Signaling Activation in Macrophages Infected with Mycobacterium scrofulaceum
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Kim KH, Kim TS, Lee JG, Park JK, Yang M, Kim JM, Jo EK, Yuk JM
- KMID: 2150821
- Immune Netw.
- 2014 Dec;14(6):307-320.
- doi: 10.4110/in.2014.14.6.307
Mycobacterium scrofulaceum is an environmental and slow-growing atypical mycobacterium. Emerging evidence suggests that M. scrofulaceum infection is associated with cervical lymphadenitis in children and pulmonary or systemic infections in immunocompromised... -
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- Dexamethasone Induces Apoptosis of Nasal Polyp-Derived Tissue Cultures Through JNK and p38 MAPK Activation
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Lee TH, Nam JG, Lee HM, Kim BY, Kang MK, Bae WY, Hur DY, Park SK
- KMID: 2278384
- Clin Exp Otorhinolaryngol.
- 2014 Jun;7(2):112-118.
OBJECTIVES: Glucocorticoids, such as dexamethasone (DEX), increase apoptosis in a variety of white cells in nasal polyps and apoptosis is an important factor in the resolution of inflammation. However, the... -
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- Mitogen-activated Protein Kinases in Inflammation
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Manzoor Z, Koh YS
- KMID: 1434747
- J Bacteriol Virol.
- 2012 Sep;42(3):189-195.
- doi: 10.4167/jbv.2012.42.3.189
Mitogen-activated protein kinases (MAPKs) play critical regulatory roles in the production of the pro-inflammatory cytokines and downstream signaling events which lead to inflammation. Inflammation is a primarily localized and protective... -
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- Dendritic Cell Activation by Glucan Isolated from Umbilicaria Esculenta
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Kim HS, Kim JY, Lee HK, Kim MS, Lee SR, Kang JS, Kim HM, Lee KA, Hong JT, Kim Y, Han SB
- KMID: 2150674
- Immune Netw.
- 2010 Dec;10(6):188-197.
- doi: 10.4110/in.2010.10.6.188
BACKGROUND: Lichen-derived glucans have been known to stimulate the functions of immune cells. However, immunostimulatory activity of glucan obtained from edible lichen, Umbilicaria esculenta, has not been reported. Thus we... -
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- TNF-alpha-induced Increase of Human beta-defensin-2 Expression in HaCaT Cell Lines
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Park YD, Lee KS
- KMID: 2248097
- Korean J Dermatol.
- 2008 Jul;46(7):867-873.
BACKGROUND: Several kinds of epithelial cells and focal lymph nodes are known to be involved in the skin's immune reaction. Especially, internal antimicrobial peptide play an important role in protecting... -
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- The Immunohistochemical Study of MAPKs Expression in Psoriatic Epidermis
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Kim SH, Ko JH, Choi KC, Chung BS
- KMID: 2158525
- Ann Dermatol.
- 2004 Sep;16(3):99-104.
- doi: 10.5021/ad.2004.16.3.99
No abstract available. -
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- Role of sphingomyelin-MAPKs pathway in heat-induced apoptosis
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Chung HS, Park SR, Choi EK, Park HJ, Griffin RJ, Song CW, Park H
- KMID: 1094699
- Exp Mol Med.
- 2003 Jun;35(3):181-188.
The role of sphingomyelinase (SMase) activation and mitogen activated protein kinases (MAPKs) activation in cellular apoptosis was investigated during the hyperthermic treatment of HL-60 human leukemia cells. Treating the cells... -
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