- The MicroRNA hsa-let-7g Promotes Proliferation and Inhibits Apoptosis in Lung Cancer by Targeting HOXB1
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Cui F, Zhou Q, Xiao K, Ma S
- KMID: 2470917
- Yonsei Med J.
- 2020 Mar;61(3):210-217.
- doi: 10.3349/ymj.2020.61.3.210
PURPOSE: The goal of this study was to explore the effects of hsa-let-7g on cell proliferation and apoptosis, and elucidate its role in lung cancer development. MATERIALS AND METHODS: The expression... -
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- Role of MicroRNA-34a in Anti-Apoptotic Effects of Granulocyte-Colony Stimulating Factor in Diabetic Cardiomyopathy
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Park IH, Song YS, Joo HW, Shen GY, Seong JH, Shin NK, Cho YJ, Lee Y, Shin JH, Lim YH, Kim H, Kim KS
- KMID: 2470965
- Diabetes Metab J.
- 2020 Feb;44(1):173-185.
- doi: 10.4093/dmj.2018.0211
BACKGROUND: Recent studies have shown that microRNAs (miRNAs) are involved in the process of cardiomyocyte apoptosis. We have previously reported that granulocyte-colony stimulating factor (G-CSF) ameliorated diastolic dysfunction and attenuated... -
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- Effect of Dialysis on Aryl Hydrocarbon Receptor Transactivating Activity in Patients with Chronic Kidney Disease
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Kim JT, Kim SH, Min HK, Jeon SJ, Sung SA, Park WH, Lee HK, Choi HS, Pak YK, Lee SY
- KMID: 2466336
- Yonsei Med J.
- 2020 Jan;61(1):56-63.
- doi: 10.3349/ymj.2020.61.1.56
PURPOSE: Elevated aryl hydrocarbon receptor (AhR) transactivating (AHRT) activity and uremia in chronic kidney disease (CKD) may interact with each other, further complicating the disease course. In this study, we... -
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- Kinesin Family Member 11 Enhances the Self-Renewal Ability of Breast Cancer Cells by Participating in the Wnt/β-Catenin Pathway
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Pei YY, Li GC, Ran J, Wan XH, Wei FX, Wang L
- KMID: 2470890
- J Breast Cancer.
- 2019 Dec;22(4):522-532.
- doi: 10.4048/jbc.2019.22.e51
PURPOSE: Our previous studies have shown that kinesin family member 11 (KIF11) is markedly overexpressed in human breast cancer cells or tissues and positively correlated with distant metastasis and prognosis... -
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- The Activation of PPAR-α and Wnt/β-catenin by Luffa cylindrica Supercritical Carbon Dioxide Extract
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Kim B
- KMID: 2468068
- Nat Prod Sci.
- 2019 Dec;25(4):341-347.
- doi: 10.20307/nps.2019.25.4.341
Luffa cylindrica (LC) is a very fast-growing climber and its fruit have been considered as agricultural wastes. We conducted to check the comparative qualities of ethanol solvent extraction (LCE) and... -
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- Genipin Inhibits Hypoxia-Induced Accumulation of HIF-1α and VEGF Expressions in Human Cervical Carcinoma Cells
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Jin CE, Lee JH, Kim GJ, Lee TH
- KMID: 2467971
- Kosin Med J.
- 2019 Dec;34(2):106-116.
- doi: 10.7180/kmj.2019.34.2.106
OBJECTIVES: Hypoxia—a characteristic of almost all types of solid tumors—has been associated with poor outcomes in several human malignancies. Genipin—an active constituent of Gardenia fruit— has been reported to exert... -
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- MicroRNA-138 Suppresses Adipogenic Differentiation in Human Adipose Tissue-Derived Mesenchymal Stem Cells by Targeting Lipoprotein Lipase
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Wang Y, Lin L, Huang Y, Sun J, Wang X, Wang P
- KMID: 2463798
- Yonsei Med J.
- 2019 Dec;60(12):1187-1194.
- doi: 10.3349/ymj.2019.60.12.1187
PURPOSE: Adipogenic differentiation of adipose tissue-derived mesenchymal stem cells (AMSCs) is critical to many disease-related disorders, such as obesity and diabetes. Studies have demonstrated that miRNA-138 (miR-138) is closely involved... -
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- Inhibition of miRNA-222-3p Relieves Staphylococcal Enterotoxin B-Induced Liver Inflammatory Injury by Upregulating Suppressors of Cytokine Signaling 1
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Zhang P, Yu J, Gui Y, Sun C, Han W
- KMID: 2460227
- Yonsei Med J.
- 2019 Nov;60(11):1093-1102.
- doi: 10.3349/ymj.2019.60.11.1093
PURPOSE: Staphylococcal enterotoxin B (SEB) has been well-documented to induce liver injury. miRNA-222-3p (miR-222-3p) was implicated in SEB-induced lung injury and several liver injuries. This study aimed to explore the... -
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- LncRNA MALAT1/MiR-145 Adjusts IL-1β-Induced Chondrocytes Viability and Cartilage Matrix Degradation by Regulating ADAMTS5 in Human Osteoarthritis
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Liu C, Ren S, Zhao S, Wang Y
- KMID: 2460226
- Yonsei Med J.
- 2019 Nov;60(11):1081-1092.
- doi: 10.3349/ymj.2019.60.11.1081
PURPOSE: Accumulating evidence suggests that microRNA-145 (miR-145) plays an important role in osteoarthritis (OA), which is a chronic progressive joint disease. Long noncoding RNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1)... -
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- microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling
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Wang L, Zhang H, Lei D
- KMID: 2459145
- Yonsei Med J.
- 2019 Oct;60(10):924-934.
- doi: 10.3349/ymj.2019.60.10.924
PURPOSE: Acute leukemia (AL) is classified as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This study aimed to investigate the effect of miR-146a on childhood AL and its... -
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- The Long Non-Coding RNA CASC2 Suppresses Cell Viability, Migration, and Invasion in Hepatocellular Carcinoma Cells by Directly Downregulating miR-183
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Sun J, Liu L, Zou H, Yu W
- KMID: 2459143
- Yonsei Med J.
- 2019 Oct;60(10):905-913.
- doi: 10.3349/ymj.2019.60.10.905
PURPOSE: Hepatocellular carcinoma (HCC) is the most common malignant tumor of liver cells. Researchers have reported that cancer susceptibility candidate 2 (CASC2), a long non-coding RNA, is down-regulated in various... -
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- Long Intergenic Non-Protein Coding RNA 665 Regulates Viability, Apoptosis, and Autophagy via the MiR-186-5p/MAP4K3 Axis in Hepatocellular Carcinoma
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Shan Y, Li P
- KMID: 2457480
- Yonsei Med J.
- 2019 Sep;60(9):842-853.
- doi: 10.3349/ymj.2019.60.9.842
PURPOSE: Long intergenic non-protein coding RNA 665 (LINC00665) plays a vital role in the development of cancer. Its function in hepatocellular carcinoma (HCC), however, remains largely unknown. MATERIALS AND METHODS: The... -
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- miR-1301/TRIAP1 Axis Participates in Epirubicin-Mediated Anti-Proliferation and Pro-Apoptosis in Osteosarcoma
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Yu L, Meng M, Bao Y, Zhang C, Gao B, Sa R, Luo W
- KMID: 2457479
- Yonsei Med J.
- 2019 Sep;60(9):832-841.
- doi: 10.3349/ymj.2019.60.9.832
PURPOSE: Epirubicin is one of the most effective drugs against osteosarcoma. miR-1301 is involved in the occurrence and development of osteosarcoma. Whether miR-1301 is responsible for the chemosensitivity of osteosarcoma... -
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- Pseudolaric acid B inhibits PAX2 expression through Wnt signaling and induces BAX expression, therefore promoting apoptosis in HeLa cervical cancer cells
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Guan D, Li C, Lv X, Yang Y
- KMID: 2457155
- J Gynecol Oncol.
- 2019 Sep;30(5):e77.
- doi: 10.3802/jgo.2019.30.e77
OBJECTIVES: Pseudolaric acid B (PAB) has been shown to inhibit the growth of various tumor cells, but the molecular details of its function are still unknown. This study investigated the... -
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- Long Noncoding RNA MALAT1 Regulates Hepatocellular Carcinoma Growth Under Hypoxia via Sponging MicroRNA-200a
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Zhao ZB, Chen F, Bai XF
- KMID: 2452953
- Yonsei Med J.
- 2019 Aug;60(8):727-734.
- doi: 10.3349/ymj.2019.60.8.727
PURPOSE: Hepatocellular carcinoma (HCC) is a common cancer worldwide. Metastasis-associated lung adenocarcinoma transcript 1 (MALAT1), a long noncoding RNA (lncRNA), has been reported to be aberrantly expressed in hypoxic cancer... -
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- Long Non-Coding RNA LINC00525 Promotes the Stemness and Chemoresistance of Colorectal Cancer by Targeting miR-507/ELK3 Axis
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Wang S, Li J, Yang X
- KMID: 2465904
- Int J Stem Cells.
- 2019 Jul;12(2):347-359.
- doi: 10.15283/ijsc19041
BACKGROUND AND OBJECTIVES: This study aims to explore the effects of a long non-coding RNA, LINC00525, on colorectal cancer (CRC) and its underlying molecular mechanisms. METHODS: The qPCR, MTT, colony formation,... -
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- Long Noncoding RNA NEAT1 Aggravates Aβ-Induced Neuronal Damage by Targeting miR-107 in Alzheimer's Disease
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Ke S, Yang Z, Yang F, Wang X, Tan J, Liao B
- KMID: 2450404
- Yonsei Med J.
- 2019 Jul;60(7):640-650.
- doi: 10.3349/ymj.2019.60.7.640
PURPOSE: Alzheimer's disease (AD) is the most common neurodegenerative disease, with a rising prevalence worldwide. Long noncoding RNAs (lncRNAs) have been found to play important roles in the development and... -
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- Ajoene, a Major Organosulfide Found in Crushed Garlic, Induces NAD(P)H:quinone Oxidoreductase Expression Through Nuclear Factor E2-related Factor-2 Activation in Human Breast Epithelial Cells
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Cho SJ, Ryu JH, Surh YJ
- KMID: 2454670
- J Cancer Prev.
- 2019 Jun;24(2):112-122.
- doi: 10.15430/JCP.2019.24.2.112
BACKGROUND: NAD(P)H:quinone oxidoreductase-1 (NQO1) is a widely-distributed flavin adenine dinucleotide-dependent flavoprotein that promotes obligatory 2-electron reductions of quinones, quinoneimines, nitroaromatics, and azo dyes. This reduces quinone levels and thereby minimizes... -
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- Upregulation of miR-27b Facilitates Apoptosis of TNF-α-Stimulated Fibroblast-Like Synoviocytes
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Lei S, Chen G, Deng L, He J
- KMID: 2446965
- Yonsei Med J.
- 2019 Jun;60(6):585-591.
- doi: 10.3349/ymj.2019.60.6.585
PURPOSE: The aim of this study was to explore the function of microRNA-27b (miR-27b) in fibroblast-like synoviocytes (FLSs) stimulated by tumor necrosis factor α (TNF-α). MATERIALS AND METHODS: mRNA expression of... -
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- miR-140-3p Knockdown Suppresses Cell Proliferation and Fibrogenesis in Hepatic Stellate Cells via PTEN-Mediated AKT/mTOR Signaling
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Wu SM, Li TH, Yun H, Ai HW, Zhang KH
- KMID: 2446962
- Yonsei Med J.
- 2019 Jun;60(6):561-569.
- doi: 10.3349/ymj.2019.60.6.561
PURPOSE: Liver fibrosis is a major cause of morbidity and mortality and the outcome of various chronic liver diseases. Activation of hepatic stellate cells (HSCs) is the key event in... -
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