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Loss of Heterozygosity at Chromosome 16q Is a Negative Prognostic Factorin Korean Pediatric Patients with Favorable Histology Wilms Tumor:A Report of the Korean Pediatric Hematology Oncology Group (K-PHOG)

Park JE, Noh OK, Lee Y, Choi HS, Han JW, Hahn SM, Lyu CJ, Lee JW, Yoo KH, Koo HH, Jeong SY, Sung KW

Purpose Loss of heterozygosity (LOH) at chromosomes 1p and 16q is a poor prognostic factor in favorable histology Wilms tumor (FHWT). This study investigated the prevalence of LOH at 1p and 16q and...
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An appraisal of pancreatic cyst fluid molecular markers

Modi RM, Pavurala R, Krishna SG

Pancreatic malignancy is the third leading cause of cancer related death in the United States with limited viable screening options. By the end of this decade, cancers are poised to...
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Clinical Significance of Previously Cryptic Copy Number Alterations and Loss of Heterozygosity in Pediatric Acute Myeloid Leukemia and Myelodysplastic Syndrome Determined Using Combined Array Comparative Genomic Hybridization plus Single-Nucleotide Polymorphism Microarray Analyses

Koh KN, Lee JO, Seo EJ, Lee SW, Suh JK, Im HJ, Seo JJ

The combined array comparative genomic hybridization plus single-nucleotide polymorphism microarray (CGH+SNP microarray) platform can simultaneously detect copy number alterations (CNA) and copy-neutral loss of heterozygosity (LOH). Eighteen children with acute...
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Loss of Heterozygosities in Five Tumor Suppressor Genes (FHIT Gene, p16, pRb, E-Cadherin and p53) in Thyroid Tumors

Kim JH, Choi KY, Lee DJ, Rho YS, Jo SJ

  • KMID: 2278408
  • Clin Exp Otorhinolaryngol.
  • 2014 Mar;7(1):53-58.
OBJECTIVES: To evaluate the loss of heterozygosities (LOH) of chromosomes 3p14 (FHIT gene), 9p21 (p16), 13q21 (pRb), 6q22 (E-cadherin) and 17p13 (p53) in various thyroid tumors. METHODS: Eighty thyroid tumor cases...
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Genetic aberrations on the short arm of chromosome 8 (8p) in tongue carcinomas

Murano A, Ono K, Koike H, Endo Y, Shimada K, Kawasaki K, Nomura H, Shiiba M, Uzawa K, Tanzawa H

Aberrations on the short arm of chromosome 8 (8p) are frequently observed in several human cancers. In this study, 20 squamous cell carcinoma (SCC) specimens from the tongue were examined...
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Analysis of copy number abnormality (CNA) and loss of heterozygosity (LOH) in the whole genome using single nucleotide polymorphism (SNP) genotyping arrays in tongue squamous cell carcinoma

Tsukasa K, Nobuharu Y, Takeshi O, Hiroki B, Takashi Y, Akira K, Nobuo T, Takahiko S

Chromosomal loss of heterozygosity (LOH) is a common mechanism for the inactivation of tumor suppressor genes in human epithelial cancers. LOH patterns can be generated through allelotyping using polymorphic microsatellite...
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False Homozygosity Results in HLA Genotyping due to Loss of Chromosome 6 in a Patient with Acute Lymphoblastic Leukemia

Park H, Hyun J, Park SS, Park MH, Song EY

Loss of heterozygosity (LOH) in chromosome 6p has been reported in a number of tumors and some hematologic malignancies, including ALL. LOH in chromosome 6p, on which the HLA genes...
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Loss of Heterozygosity at 1p, 7q, 17p, and 22q in Meningiomas

Chang IB, Cho BM, Moon SM, Park SH, Oh SM, Cho SJ

OBJECTIVE: Allelic losses or loss of heterozygosity (LOH) at many chromosomal loci have been found in the cells of meningiomas. The objective of this study was to evaluate LOH at...
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Microsatellite Instability and p53 Gene Loss of Heterozygosity in Hepatocellular Carcinoma

Kim JS, Lim MS, Kim DJ, Kim JS, Kim KS, Kim HK, Cho SJ, Kwon MJ, Nam ES, Choi KC, Shin HS, Chae GB

  • KMID: 2083315
  • Korean J Hepatobiliary Pancreat Surg.
  • 2009 Sep;13(3):143-151.
PURPOSE: Hepatocellular carcinoma (HCC) shows various molecular and genetic alterations in its development and progression. Recently, microsatellite instability (MSI) and the loss of heterozygosity (LOH), have been postulated as useful...
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Loss of Heterozygosity on Chromosome 15q15 Near Thrombospondin-1 Gene in Breast Carcinomas

Kim J, Kim KM, Lee H, Lee K, Rhyu MG, Lee A, Kang SJ, Lee KY

  • KMID: 1979339
  • Korean J Pathol.
  • 2009 Jun;43(3):221-230.
BACKGROUND: Chromosome 15q15 near the thrombospondin-1 (THBS-1) gene may be associated with tumor progression and metastasis. To clarify the potential role of the15q15 region in progression of breast carcinoma, we...
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Chromosomal Losses are Associated with Hypomethylation of the Gene-Control Regions in the Stomach with a Low Number of Active Genes

Jung YC, Hong SJ, Kim YH, Kim SJ, Kang SJ, Choi SW, Rhyu MG

Transitional-CpG methylation between unmethylated promoters and nearby methylated retroelements plays a role in the establishment of tissue-specific transcription. This study examined whether chromosomal losses reducing the active genes in cancers...
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Promoter hypermethylation and loss of heterozygosity of FHIT genes in squamous cell carcinoma of uterine cervix

Ko OJ, Choi CH, Kim TJ, Kim WY, Lee KM, Choi JJ, Lee JW, Kim BG, Lee JH, Bae DS

  • KMID: 2244565
  • Korean J Gynecol Oncol.
  • 2007 Jun;18(2):139-145.
OBJECTIVE: This study was to investigate the status of hypermethylation and loss of heterozygosity (LOH) in chromosome 3p tumor-suppressor gene for cervical carcinoma. METHODS: We examined the promoter methylation status...
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Molecular Biological Differences Between Younger and Older Breast Cancer Patients Based on the Status of a Microsatellite Marker

Seo SW, Yoon JH, Park MH, Nam JH

  • KMID: 2040611
  • J Korean Surg Soc.
  • 2007 Jun;72(6):444-452.
PURPOSE: Younger women exhibit more aggressive pathological features of breast cancer than older women, based on previous studies. We wished to evaluate any molecular biological differences in breast cancer between...
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Methylation and Chromosomal Losses in Squamous Cell Carcinoma of the Head and Neck

Hong MW, Hong SJ, Rhyu MG, Sun DI, Cho SH, Kim MS

  • KMID: 1977238
  • Korean J Otolaryngol-Head Neck Surg.
  • 2007 Feb;50(2):145-156.
BACKGROUND AND OBJECTIVES: Methylation of CpG islands is associated with delayed replication, condensed chromatin and inhibition of transcription initiation in many human cancers. Another concern with regards to CpG methlation...
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Frequency of Loss of Heterozygosity on Chromosome 17 in Intrahepatic Cholangiocarcinoma

Kim HJ, Kang CD, Lee SJ, Cho SJ, Kim JS

  • KMID: 782762
  • Korean J Gastroenterol.
  • 2006 Sep;48(3):188-194.
BACKGROUND/AIMS: Intrahepatic cholangiocarcinoma is the second most common intrahepatic neoplasm. Carcinogenesis is believed to be a multistage process that occurs as a result of mutations in oncogenes and tumor suppressor...
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Genetic and expression analysis of the KCNRG gene in hepatocellular carcinomas

Cho YG, Kim CJ, Song JH, Rhie DJ, Park YK, Kim SY, Nam SW, Yoo NJ, Lee JY, Park WS

  • KMID: 1094150
  • Exp Mol Med.
  • 2006 Jun;38(3):247-255.
The potassium channels are ubiquitous multisubunit membrane proteins, and potassium-dependent alterations in the membrane potential play an important role in the proliferation of many types of cells. This study analyzed...
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The Extent of Chromosomal Losses and the Status of CpG Methylation in Squamous Cell Carcinoma of the Head and Neck

Cho KJ, Kim MS, Rhyu MG, Cho SH

  • KMID: 1875143
  • Korean J Otolaryngol-Head Neck Surg.
  • 2005 Sep;48(9):1143-1153.
BACKGROUND AND OBJECTIVES: Carcinogenesis is known to arise as a result of the accumulation of genetic alterations including unilateral chromosomal losses and epigenetic modification. In this study, we investigated the...
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Analysis of Loss of Heterozygosity in Korean Patients with Keratoacanthoma

Ha TW, Han KH, Son DG, Kim SP, Kim DK

Loss of heterozygosity (LOH) has been established as an important genetic mechanism giving rise to malignant neoplasia. The mechanism of LOH has been shown to cause basal cell carcinoma and...
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DNA Hypermethylation and the Loss of Heterozygosity of Chromosome 16q22 in Hepatocellular Carcinoma

Oh HE, Cheong JC, Joo SH, Jeon JY, Kim JS, Cho SJ, Nam ES, Shin HS

  • KMID: 1890126
  • Korean J Hepatobiliary Pancreat Surg.
  • 2005 Mar;9(1):16-22.
PURPOSE: E-cadherin gene, located on chromosome 16q22, may play crucial roles in the cell adhesion and propensity for more malignant properties of various organs. Although loss of heterozygosity (LOH) and...
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Adequate Microsatellite Markers for 1p/19q Loss of Heterozygosity of Oligodendroglial Tumors in Korean Patients

Kim SH, Kim H, Kim TS

  • KMID: 2275438
  • Korean J Pathol.
  • 2005 Feb;39(1):23-33.
BACKGROUND: It is well known that oligodendrogliomas can be divided into two groups according to the 1p/19q or 1p loss of heterozygosity (LOH) status because oligodendrogliomas with the 1p/19q LOH...
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