- m6A Methyltransferase METTL3 Reduces Hippocampal Neuron Apoptosis in a Mouse Model of Autism Through the MALAT1/SFRP2/Wnt/β-catenin Axis
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Ming Y, Deng Z, Tian X, Jia Y, Ning M, Cheng S
- KMID: 2535964
- Psychiatry Investig.
- 2022 Oct;19(10):771-787.
- doi: 10.30773/pi.2021.0370
Objective Hippocampal neuron apoptosis contributes to autism, while METTL3 has been documented to possess great potentials in neuron apoptosis. Our study probed into the role of METTL3 in neuron apoptosis... -
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- Long Noncoding RNA FBXL19-AS1-Mediated Ulcerative Colitis-Associated Intestinal Epithelial Barrier Defect
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Zhao X, Cui DJ, Yang Lc, Yuan WQ, Yan F
- KMID: 2533935
- Tissue Eng Regen Med.
- 2022 Oct;19(5):1077-1088.
- doi: 10.1007/s13770-022-00479-9
BACKGROUND: This study commenced to uncover the role of long non-coding RNA FBXL19 antisense RNA 1 (FBXL19-AS1) in the development of ulcerative colitis (UC) and its possible mechanism. METHODS: FBXL19-AS1 expression... -
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- Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression
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Jiang X, Zhu Q, Wu P, Zhou F, Chen J
- KMID: 2460913
- Ann Lab Med.
- 2020 Mar;40(2):155-163.
- doi: 10.3343/alm.2020.40.2.155
BACKGROUND: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with... -
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- Circulating HOTAIR LncRNA Is Potentially Up-regulated in Coronary Artery Disease
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Avazpour N, Hajjari M, Yazdankhah S, Sahni A, Foroughmand AM
- KMID: 2439215
- Genomics Inform.
- 2018 Dec;16(4):e25.
- doi: 10.5808/GI.2018.16.4.e25
Coronary artery disease (CAD) is one of the leading causes of death and disability all around the world. Recent studies have revealed that aberrantly regulated long non-coding RNA (lncRNA) as... -
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- Noncoding RNAs as therapeutic targets in early stage diabetic kidney disease
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Kato M
- KMID: 2447159
- Kidney Res Clin Pract.
- 2018 Sep;37(3):197-209.
- doi: 10.23876/j.krcp.2018.37.3.197
Diabetic kidney disease (DKD) is a major renal complication of diabetes that leads to renal dysfunction and end-stage renal disease (ESRD). Major features of DKD include accumulation of extracellular matrix... -
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- Long Noncoding RNA Signature and Disease Outcome in Estrogen Receptor-Positive Breast Cancer Patients Treated with Tamoxifen
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Wang G, Chen X, Liang Y, Wang W, Fang Y, Shen K
- KMID: 2421368
- J Breast Cancer.
- 2018 Sep;21(3):277-287.
- doi: 10.4048/jbc.2018.21.e39
PURPOSE: Recent data have shown that the expression levels of long noncoding RNAs (lncRNAs) are associated with tamoxifen sensitivity in estrogen receptor (ER)-positive breast cancer. Herein, we constructed an lncRNA-based... -
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- Long Noncoding RNA HEIH Promotes Colorectal Cancer Tumorigenesis via Counteracting miR-939-Mediated Transcriptional Repression of Bcl-xL
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Cui C, Zhai D, Cai L, Duan Q, Xie L, Yu J
- KMID: 2417888
- Cancer Res Treat.
- 2018 Jul;50(3):992-1008.
- doi: 10.4143/crt.2017.226
PURPOSE: Studies have found that long noncoding RNA HEIH (lncRNA-HEIH) is upregulated and facilitates hepatocellular carcinoma tumor growth. However, its clinical significances, roles, and action mechanism in colorectal cancer (CRC)... -
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- Long Non-coding RNA HOXA11 Antisense Promotes Cell Proliferation and Invasion and Predicts Patient Prognosis in Serous Ovarian Cancer
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Yim GW, Kim HJ, Kim LK, Kim SW, Kim S, Nam EJ, Kim YT
- KMID: 2388311
- Cancer Res Treat.
- 2017 Jul;49(3):656-668.
- doi: 10.4143/crt.2016.263
PURPOSE: The biological function of long non-coding RNAs (lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its... -
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- Epigenetic Silencing of MORT Is an Early Event in Cancer and Is Associated with Luminal, Receptor Positive Breast Tumor Subtypes
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Vrba L, Futscher B
- KMID: 2389758
- J Breast Cancer.
- 2017 Jun;20(2):198-202.
- doi: 10.4048/jbc.2017.20.2.198
Immortality is an essential characteristic of cancer cells; a recent transcriptomic study of epithelial cell immortalization has linked epigenetic silencing of the long noncoding RNA Mortal Obligate RNA Transcript (MORT;... -
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- LncRNA Taurine-Upregulated Gene 1 Promotes Cell Proliferation by Inhibiting MicroRNA-9 in MCF-7 Cells
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Zhao XB, Ren GS
- KMID: 2362921
- J Breast Cancer.
- 2016 Dec;19(4):349-357.
- doi: 10.4048/jbc.2016.19.4.349
PURPOSE: This study was designed to investigate the role of taurine-upregulated gene 1 (TUG1) in MCF-7 breast cancer cells and the molecular mechanism involved in the regulation of microRNA-9 (miR-9). METHODS:... -
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- BRAF-Activated Long Noncoding RNA Modulates Papillary Thyroid Carcinoma Cell Proliferation through Regulating Thyroid Stimulating Hormone Receptor
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Zheng H, Wang M, Jiang L, Chu H, Hu J, Ning J, Li B, Wang D, Xu J
- KMID: 2454348
- Cancer Res Treat.
- 2016 Apr;48(2):698-707.
- doi: 10.4143/crt.2015.118
PURPOSE: The importance of long noncoding RNAs (lncRNAs) in tumorigenesis has recently been demonstrated. However, the role of lncRNAs in development of thyroid cancer remains largely unknown. MATERIALS AND METHODS: Using... -
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- Long Noncoding RNA MHRT Protects Cardiomyocytes against H2O2-Induced Apoptosis
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Zhang J, Gao C, Meng M, Tang H
- KMID: 2170536
- Biomol Ther.
- 2016 Jan;24(1):19-24.
- doi: 10.4062/biomolther.2015.066
Acute myocardial infarction (AMI) remains a leading cause of morbidity and mortality worldwide. The exploration of new biomarkers with high sensitivity and specificity for early diagnosis of AMI therefore becomes... -
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