- New Therapeutic Approaches to the Treatment of Dyslipidemia 1: ApoC-III and ANGPTL3
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Kim JY, Kim NH
- KMID: 2539212
- J Lipid Atheroscler.
- 2023 Jan;12(1):23-36.
- doi: 10.12997/jla.2023.12.1.23
Low-density lipoprotein cholesterol (LDL-C)-lowering therapy that increases LDL receptor expression in several ways robustly reduces the risk of atherosclerotic cardiovascular disease (CVD). However, a substantial risk of CVD still remains... -
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- 2022 Consensus Statement on the Management of Familial Hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, on behalf of Task Force Team for Familial Hypercholesterolemia, Korean Society of Lipid and Atherosclerosis
- KMID: 2536631
- Korean J Med.
- 2022 Dec;97(6):339-352.
- doi: 10.3904/kjm.2022.97.6.339
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- Exploring differentially expressed genes related to metabolism by RNASeq in porcine embryonic fibroblast after insulin treatment
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Liang Y, Wang J, Li X, Wu S, Jiang C, Wang Y, Li X, Liu ZH, Mu Y
- KMID: 2536697
- J Vet Sci.
- 2022 Nov;23(6):e90.
- doi: 10.4142/jvs.22088
Background: Insulin regulates glucose homeostasis and has important effects on metabolism, cell growth, and differentiation. Depending on the cell type and physiological context, insulin signal has specific pathways and biological... -
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- Effects of sleep deprivation on coronary heart disease
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Wei R, Duan X, Guo L
- KMID: 2532759
- Korean J Physiol Pharmacol.
- 2022 Sep;26(5):297-305.
- doi: 10.4196/kjpp.2022.26.5.297
The presence of artificial light enables humans to be active 24 h a day. Many people across the globe live in a social culture that encourages staying up late to meet... -
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- 2022 Consensus statement on the management of familial hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, on behalf of Task Force Team for Familial Hypercholesterolemia, Korean Society of Lipid and Atherosclerosis
- KMID: 2533135
- Korean J Intern Med.
- 2022 Sep;37(5):931-944.
- doi: 10.3904/kjim.2022.121
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- 2022 Consensus Statement on the Management of Familial Hypercholesterolemia in Korea
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Lee CJ, Yoon M, Kang HJ, Kim BJ, Choi SH, Jeong IK, Lee SH, oboTFTfFHKSoLaA
- KMID: 2533272
- J Lipid Atheroscler.
- 2022 Sep;11(3):213-228.
- doi: 10.12997/jla.2022.11.3.213
Familial hypercholesterolemia (FH) is the most common monogenic disorder. Due to the marked elevation of cardiovascular risk, the early detection, diagnosis, and proper management of this disorder are critical. Herein,... -
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- Canagliflozin Ameliorates Nonalcoholic Fatty Liver Disease by Regulating Lipid Metabolism and Inhibiting Inflammation through Induction of Autophagy
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Xu Z, Hu W, Wang B, Xu T, Wang J, Wei D
- KMID: 2530686
- Yonsei Med J.
- 2022 Jul;63(7):619-631.
- doi: 10.3349/ymj.2022.63.7.619
Purpose: Nonalcoholic fatty liver disease (NAFLD) is closely associated with metabolic diseases, including obesity and diabetes, and has gradually become the most common cause of chronic liver disease. We investigated... -
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- Dietary supplementation with Korean pine nut oil decreases body fat accumulation and dysregulation of the appetite-suppressing pathway in the hypothalamus of high-fat diet-induced obese mice
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Shin S, Park S, Lim Y, Han SN
- KMID: 2530391
- Nutr Res Pract.
- 2022 Jun;16(3):285-297.
- doi: 10.4162/nrp.2022.16.3.285
BACKGROUND/OBJECTIVES: Korean pine nut oil (PNO) has been reported to suppress appetite by increasing satiety hormone release. However, previous studies have rendered inconsistent results and there is lack of information... -
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- Reduction of oocyte lipid droplets and meiotic failure due to biotin deficiency was not rescued by restoring the biotin nutritional status
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Tsuji A, Ikeda Y, Murakami M, Kitagishi Y, Matsuda S
- KMID: 2530393
- Nutr Res Pract.
- 2022 Jun;16(3):314-329.
- doi: 10.4162/nrp.2022.16.3.314
BACKGROUND/OBJECTIVES: Oocyte lipid droplets play a crucial role in meiosis and embryo development. Biotin is associated with fatty acid synthesis and is the coenzyme for acetyl-CoA carboxylase (ACC). The effects... -
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- Inhibitory effect of water-soluble mulberry leaf extract on hepatic lipid accumulation in high-fat diet-fed rats via modulation of hepatic microRNA-221/222 expression and inflammation
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Lee MS, Kim C, Ko H, Kim Y
- KMID: 2529467
- J Nutr Health.
- 2022 Apr;55(2):227-239.
- doi: 10.4163/jnh.2022.55.2.227
Purpose: This study investigated the effects of water-soluble mulberry leaf extract (ME) on hepatic lipid accumulation in high-fat diet-fed rats via the regulation of hepatic microRNA (miR)-221/222 and inflammation. Methods: Male... -
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- Obesity Exacerbates Coxsackievirus Infection via Lipid-Induced Mitochondrial Reactive Oxygen Species Generation
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Kim SR, Song JH, Ahn JH, Jeong MS, Yang YM, Cho J, Jeong JH, Cha Y, Kim KN, Kim HP, Chang SY, Ko HJ
- KMID: 2536246
- Immune Netw.
- 2022 Apr;22(2):e19.
- doi: 10.4110/in.2022.22.e19
Coxsackievirus B3 (CVB3) infection causes acute pancreatitis and myocarditis. However, its pathophysiological mechanism is unclear. Here, we investigated how lipid metabolism is associated with exacerbation of CVB3 pathology using high-fat... -
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- Repeated Low High-Density Lipoprotein Cholesterol and the Risk of Thyroid Cancer: A Nationwide Population- Based Study in Korea
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Kim J, Kim MK, Baek KH, Song KH, Han K, Kwon HS
- KMID: 2529222
- Endocrinol Metab.
- 2022 Apr;37(2):303-311.
- doi: 10.3803/EnM.2021.1332
Background: High-density lipoprotein cholesterol (HDL-C) plays an important role in the reverse cholesterol transport pathway and prevents atherosclerosis-mediated disease. It has also been suggested that HDL-C may be a protective... -
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- Iron Overload and the Risk of Diabetes in the General Population: Results of the Chinese Health and Nutrition Survey Cohort Study
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Gao H, Yang J, Pan W, Yang M
- KMID: 2527723
- Diabetes Metab J.
- 2022 Mar;46(2):307-318.
- doi: 10.4093/dmj.2020.0287
Background: Recent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among... -
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- Effects of quercetin on the improvement of lipid metabolism through regulating hepatic AMPK and microRNA-21 in high cholesterol diet-fed mice
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Lee MS, Kim Y
- KMID: 2526923
- J Nutr Health.
- 2022 Feb;55(1):36-46.
- doi: 10.4163/jnh.2022.55.1.36
Purpose: Quercetin is a polyphenolic flavonoid abundant in many fruits and vegetables. It has potential health-beneficial properties, such as antioxidant, anti-obesity, anti-cancer, anti-diabetic and anti-inflammatory effects. The purpose of this... -
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- Effects of taurine and ginseng extracts on energy metabolism during exercise and their anti-fatigue properties in mice
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Kim J, Beak S, Ahn S, Moon BS, Kim BS, Lee SJ, Oh SJ, Park HY, Kwon SH, Shin CH, Lim K, Lee KP
- KMID: 2525511
- Nutr Res Pract.
- 2022 Feb;16(1):33-45.
- doi: 10.4162/nrp.2022.16.1.33
BACKGROUND/OBJECTIVES: Ginseng extract (GSE) and taurine (TR) are widely used antifatigue resources in functional foods. However, the mechanism underlying the antifatigue effects of GSE and TR are still unclear. Hence,... -
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- Identification of sphingosine 1-phosphate level and MAPK/ERK signaling in pancreatic β cells
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Park JH, Park KK, Choe JY, Jang KM
- KMID: 2523831
- Ann Pediatr Endocrinol Metab.
- 2021 Dec;26(4):252-258.
- doi: 10.6065/apem.2040266.133
Purpose: Sphingosine kinase is a lipid kinase that phosphorylates sphingosine to generate sphingosine 1-phosphate (S1P). S1P regulates pancreatic islet β-cell endoplasmic reticulum stress and proliferation. Type 1 and type 2... -
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- Lipid Metabolism, Disorders and Therapeutic Drugs – Review
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Natesan V, Kim SJ
- KMID: 2522247
- Biomol Ther.
- 2021 Nov;29(6):596-604.
- doi: 10.4062/biomolther.2021.122
Different lifestyles have an impact on useful metabolic functions, causing disorders. Different lipids are involved in the metabolic functions that play various vital roles in the body, such as structural... -
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- The PNPLA3 rs738409 Variant but not MBOAT7 rs641738 is a Risk Factor for Nonalcoholic Fatty Liver Disease in Obese U.S. Children of Hispanic Ethnicity
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Mansoor S, Maheshwari A, Guglielmo MD, Furuya K, Wang M, Crowgey E, Molle-Rios Z, He Z
- KMID: 2520140
- Pediatr Gastroenterol Hepatol Nutr.
- 2021 Sep;24(5):455-469.
- doi: 10.5223/pghn.2021.24.5.455
Purpose The rs641738 C>T in membrane-bound O-acyltransferase domain-containing protein 7 (MBOAT7) is implicated, along with the rs738409 C>G polymorphism in patatin-like phospholipase domain-containing protein 3 (PNPLA3), in nonalcoholic fatty liver disease... -
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- Targeting Fatty Acid Metabolism in Head and Neck Cancer
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Kim JH, Ku M, Yang J, Byeon HK
- KMID: 2517721
- Korean J Otorhinolaryngol-Head Neck Surg.
- 2021 Jun;64(6):381-390.
- doi: 10.3342/kjorl-hns.2021.00066
Reprogramming of cellular metabolism is an important, emerging, and universal hallmark of cancer which has received considerable attention during the recent era of cancer research. Cancer cells show characteristic alterations... -
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- Zebrafish as an Emerging Model for Dyslipidemia and Associated Diseases
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Ka J, Jin SW
- KMID: 2512930
- J Lipid Atheroscler.
- 2021 Jan;10(1):42-56.
- doi: 10.12997/jla.2021.10.1.42
Dyslipidemia related diseases such as hyperlipidemia and atherosclerosis are the leading cause of death in humans. While cellular and molecular basis on the pathophysiology of dyslipidemia has been extensively investigated... -
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