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The Discovery of Druggable Anti-aging Agents

Yalcin G, Lee CK

Caloric restriction (CR) has been shown to extend the lifespan of many species. Research to identify compounds that imitate the results of CR has shown extensions of both lifespan and...
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Altered GABAergic Signaling in Brain Disease at Various Stages of Life

Kim YS, Yoon BE

In the healthy brain, gamma-aminobutyric acid (GABA) is regulated by neurons and glia. This begs the question: what happens in the malfunctioning brain? There are many reasons why diseases occur,...
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Moringa oleifera Prolongs Lifespan via DAF-16/FOXO Transcriptional Factor in Caenorhabditis elegans

Im JS, Lee HN, Oh JW, Yoon YJ, Park JS, Park JW, Kim JH, Kim YS, Cha DS, Jeon H

Here in this study, we investigated the lifespan-extending effect and underlying mechanism of methanolic extract of Moringa olelifa leaves (MML) using Caenorhabditis elegans (C. elegans) model system. To define the...
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Alpha-Ketoglutarate: Physiological Functions and Applications

Wu N, Yang M, Gaur U, Xu H, Yao Y, Li D

Alpha-ketoglutarate (AKG) is a key molecule in the Krebs cycle determining the overall rate of the citric acid cycle of the organism. It is a nitrogen scavenger and a source...
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Lifespan Extending and Stress Resistant Properties of Vitexin from Vigna angularis in Caenorhabditis elegans

Lee EB, Kim JH, Cha YS, Kim M, Song SB, Cha DS, Jeon H, Eun JS, Han S, Kim DK

Several theories emphasize that aging is closely related to oxidative stress and disease. The formation of excess ROS can lead to DNA damage and the acceleration of aging. Vigna angularis...
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Immortalization of Primary Keratinocytes and Its Application to Skin Research

Choi M, Lee C

As a major component of the epidermal tissue, a primary keratinocyte has served as an essential tool not only for the study of pathogenesis of skin-related diseases but also for...
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Lindera obtusiloba Extends Lifespan of Caenorhabditis elegans

Kim HN, Seo HW, Kim BS, Lim HJ, Lee HN, Park JS, Yoon YJ, Oh JW, Oh MJ, Kwon J, Oh CH, Cha DS, Jeon H

Lindera obtusiloba has been widely used as a traditional medicine for the treatment of lots of diseases, including abdominal pain, bruise, and hepatocirrhosis. Here in this study, we elucidated the...
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Genistein from Vigna angularis Extends Lifespan in Caenorhabditis elegans

Lee EB, Ahn D, Kim BJ, Lee SY, Seo HW, Cha YS, Jeon H, Eun JS, Cha DS, Kim DK

The seed of Vigna angularis has long been cultivated as a food or a folk medicine in East Asia. Genistein (4',5,7-trihydroxyisoflavone), a dietary phytoestrogen present in this plant, has been...
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Acanthopanax sessiliflorus stem confers increased resistance to environmental stresses and lifespan extension in Caenorhabditis elegans

Park JK, Kim CK, Gong SK, Yu AR, Lee MY, Park SK

BACKGROUND/OBJECTIVES: Acanthopanax sessiliflorus is a native Korean plant and used as traditional medicine or an ingredient in many Korean foods. The free radical theory of aging suggests that cellular oxidative...
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Molecular Links between Caloric Restriction and Sir2/SIRT1 Activation

Wang Y

Ageing is the most significant risk factor for a range of prevalent diseases, including cancer, cardiovascular disease, and diabetes. Accordingly, interventions are needed for delaying or preventing disorders associated with...
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Reliability and Validity of the Korean Version of the Lifespan Sibling Relationship Scale

Jeong HS, Jeong EJ, Yu SY, Lyoo YC, Im JJ, Bae S, Kim JE

The sibling relationship and its potential impact on neurodevelopment and mental health are important areas of neuroscientific research. Validation of the tools assessing the quality of the sibling relationship would...
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Influence of operator's experience level on lifespan of the WaveOne Primary file in extracted teeth

Saleh AM, Tavanafar , Vakili-Gilani P, Al Sammerraie NJ, Rashid F

  • KMID: 2316853
  • Restor Dent Endod.
  • 2013 Nov;38(4):222-226.
OBJECTIVES: The aim of this study was to assess the influence of operator experience level on the lifespan of the WaveOne Primary file (Dentsply Maillefer, Ballaigues, Switzerland) in extracted teeth. MATERIALS...
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The Longevity Properties of 1,2,3,4,6-Penta-O-Galloyl-beta-D-Glucose from Curcuma longa in Caenorhabditis elegans

Ahn D, Cha DS, Lee EB, Kim BJ, Lee SY, Jeon H, Ahn MS, Lim HW, Lee HY, Kim DK

  • KMID: 2170661
  • Biomol Ther.
  • 2013 Nov;21(6):442-446.
Here in this study, we isolated 1,2,3,4,6-penta-O-galloyl-beta-D-glucose (PGG) from Curcuma longa L. and elucidated the lifespanextending effect of PGG using Caenorhabditis elegans model system. In the present study, PGG demonstrated...
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Korean Red Ginseng Tonic Extends Lifespan in D. melanogaster

Kim MS

  • KMID: 1502494
  • Biomol Ther.
  • 2013 May;21(3):241-245.
Aging is the single most important risk factor that increases susceptibility to many forms of diseases. As such, much effort has been put forward to elucidate the mechanisms behind the...
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High glucose diets shorten lifespan of Caenorhabditis elegans via ectopic apoptosis induction

Choi SS

  • KMID: 2313520
  • Nutr Res Pract.
  • 2011 Jun;5(3):214-218.
Diets based on carbohydrates increase rapidly the blood glucose level due to the fast conversion of carbohydrates to glucose. High glucose diets have been known to induce many lifestyle diseases....
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Low-dose Gamma-irradiation Effect on Early Stage Development and Lifespan in Various Strains of Drosophila melanogaster

Lee JW, Seong KM, Kim CS, Nam SY, Yang KH, Jin YW

  • KMID: 2075037
  • Korean J Occup Environ Med.
  • 2008 Sep;20(3):225-232.
OBJECTIVES: Although ionizing radiation is recognized as being harmful to humans, debate continues regarding the effects of low doses of ionizing radiation. Some studies have reported that low doses of...
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Luteal lifespan and fertility after estrus synchronization in goats

Chao LM, Takayama K, Nakanishi , Hamana K, Takagi M, Kubota C, Kojima T

The present experiment aims to examine the efficiency of estrus synchronization using progesterone and equine chorionic gonadotrophin (eCG) and to look at luteal function. During the non-breeding and breeding season,...
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