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SIRT1 Inhibits p53 but not NF-kappaB Transcriptional Activity during Differentiation of Mouse Embryonic Stem Cells into Embryoid Bodies

Lhee SJ, Song EK, Kim YR, Han MK

  • KMID: 1735406
  • Int J Stem Cells.
  • 2012 Nov;5(2):125-129.
BACKGROUND AND OBJECTIVES: SIRT1, a histone diacetylase, modify transactivation function of various transcription factor including p53 and NF-kappaB. p53 and NF-kappaB is involved in in vitro differentiation of mouse embryonic...
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