- Effect of Blocking of Antidromic Impulses by Capsaicin on Mechanical Allodynia in a Rat Model of Peripheral Neuropathic Pain
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Shin JW, Hahm KD, Leem JW, Park CH, Ku SW, Choi Y, Leem JG, Lee C
- KMID: 2104817
- J Korean Pain Soc.
- 2004 Jun;17(1):5-9.
- doi: 10.3344/jkps.2004.17.1.5
BACKGROUND: Nerve impulses that are generated in injured nociceptive fibers and enter the spinal cord are known to cause central sensitization leading to neuropathic pain. Injury-induced impulses that are transmitted... -
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- Effects of L-NAME on the Mechanical Hyperalgesia after the Development of Inflammation by Freund's Complete Adjuvant in Rat Paw
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Kim MK, Choi Y, Kong HS, Leem JW, Leem HS, Chung SJ, Lee C
- KMID: 1946736
- J Korean Pain Soc.
- 1999 Nov;12(2):171-176.
BACKGROUND: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. From our previous experiment, NOS inhibitor, L-NAME given during the induction period decrease mechanical hyperalgesia occurred by Freund's complete... -
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- Patterns of Nerve Conduction Blockade by Different Combinations of Lidocaine-bupivacaine Mixture
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Cho SK, Leem JW, Leem HS, Han SM, Kong HS, Choi Y
- KMID: 2031516
- Korean J Anesthesiol.
- 2000 Apr;38(4):708-712.
- doi: 10.4097/kjae.2000.38.4.708
BACKGROUND: A mixture of local anesthetics such as lidocaine and bupivacaine has frequently been used in clinical practice. The rationale behind this is to take advantage of lidocaine's rapid... -
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- Effect of Adrenergic Receptors on the Nerve Conduction in Rat Sciatic Nerves
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Lee C, Jung SY, Choi Y, Leem JW, Leem HS, Yang HC, Han SM, Kong HS, Lim SW
- KMID: 1946737
- J Korean Pain Soc.
- 1999 Nov;12(2):177-182.
BACKGROUND: Clonidine, an a adrenergic agonist blocks nerve conduction. However, in our previous experiment we found that adrenaline neither blocks nerve conduction by itself nor augment nerve conduction blockade by lidocaine... -
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- Adrenergic sensitivity of uninjured C-fiber nociceptors in neuropathic rats
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Nam TS, Yeon DS, Leem JW, Paik KS
- KMID: 1758517
- Yonsei Med J.
- 2000 Apr;41(2):252-257.
- doi: 10.3349/ymj.2000.41.2.252
We investigated the adrenergic sensitivity of afferent fibers in the L4 dorsal roots of rats with a unilateral ligation of the L5-L6 spinal nerves. About 12% of nociceptive fibers on... -
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- Enflurane Anesthesia Augments the Peripheral Venous Pressure Changes during Non-invasive Blood Pressure Measurement
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Sim JY, Choi Y, Leem JW, Jung HS, Yang HS, Lee DM
- KMID: 1935133
- Korean J Anesthesiol.
- 1999 Jan;36(1):119-125.
- doi: 10.4097/kjae.1999.36.1.119
BACKGROUND: Venous regurgitation into the infusion line and subsequent occlusion frequently occurs during blood pressure (BP) measurement. The purpose of this study was to obtain the pattern and the actual... -
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- L - NAME Inhibits Hyperalgesia Induced by Freund's Complete Adjuvant in Rat Paw
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Leem JW, Choi Y, Lee C, Song MH, Lee DM, Raja SN
- KMID: 2425666
- J Korean Pain Soc.
- 1998 Oct;11(2):194-200.
BACKGROUND: Effect of nitric oxide on the hyperalgesia induced by inflammation is controversial. We attempted to find out the peripheral effects of nitric oxide (NO) on hyperalgesia induced by Freund's eomplete... -
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- The Phantom Limb Sensation Expressed by Spinal Anesthesia
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Choi Y, Lee PH, Leem JW, Yoon MJ, Shin JY, Yang HS, Lee DM
- KMID: 2299262
- Korean J Anesthesiol.
- 1997 Dec;33(6):1134-1141.
- doi: 10.4097/kjae.1997.33.6.1134
BACKGROUND: Phantom limb sensation is an unusual position sense of the extremity during nerve block that the position of extremity is misinterpreted as being flexed, or elevated, when actually they... -
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- The Effect of Tourniquet Inflation on Neural Functions: A Volunteer Study
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Jun HJ, Choi Y, Jung HS, Kim TY, Jung SY, Leem JW
- KMID: 2335847
- J Korean Pain Soc.
- 1999 May;12(1):16-20.
BACKGROUND: Tourniquet pain has important impacts an anesthesia. Tourniquet pain and accompanying cardiovascular changes are important factors that make patients in distress during anesthesia. As tourniquet pain may be modified by anesthesia,... -
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- Dextromethorphan Pretreatment Does not Reduce the Tourniquet Pain in Normal Volunteers
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Chung SR, Choi Y, Leem JW, Min HK, Jun HJ, Park TS
- KMID: 2031554
- Korean J Anesthesiol.
- 2000 Aug;39(2):153-159.
- doi: 10.4097/kjae.2000.39.2.153
BACKGROUND: Dextromethorphan (DEX) is an NMDA receptor antagonist which has recently been introduced for the treatment of chronic pain mainly to reduce the central sensitization component of pain. It is... -
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- Effect of Nitric Oxide on the Change of Spinal Neuropeptide in the Inflammation Model by Freund's Complete Adjuvant
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Hwang SJ, Chung TJ, Shin DY, Hong HN, Leem JW, Hwang JH, Choi Y
- KMID: 1559121
- Korean J Anat.
- 2001 Jun;34(3):293-302.
Injection of Freund's complete adjuvant (FCA) into the plantar surface of the rat induces inflammatory responses with accompanying pain behaviors. Signs of pain behaviors observed in FCA-injected animals are reported... -
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- The Effect of Thyrotropin Releasing Hormone on somatosensory Evoked Potentials in Cats with Spinal Cord Injury
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Park CO, Lee KC, Leem JW, Paik KS
- KMID: 2068312
- J Korean Neurosurg Soc.
- 1987 Mar;16(1):255-264.
The therapeutic goal for the spinal injury has been focused on preventing the secondary ischemic changes because of the poor regeneration of human spinal cord. Naloxone, an antagonist of endogenous... -
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- The Role of the Peripheral Chemokine, CCL3, in Hyperalgesia following Peripheral Nerve Injury in the Rat
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Leem JW, Lee HJ, Nam TS, Yoon DM
- KMID: 1978706
- Korean J Pain.
- 2008 Dec;21(3):187-196.
- doi: 10.3344/kjp.2008.21.3.187
BACKGROUND: Upregulation of one type of the pro-inflammatory chemokine (CCL2) and its receptor (CCR2) following peripheral nerve injury contributes to the induction of neuropathic pain. Here, we examined whether another... -
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- Effects of Bupivacaine Pretreatment at the Periphery on the Expression of Mechanical Hyperalgesia in a Rat Model of Peripheral Neuropathy
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Chung YB, Leem JW, Chung EJ, Lee JC, Choi Y
- KMID: 2335972
- J Korean Pain Soc.
- 2001 Jun;14(1):7-11.
BACKGROUND: Although several mechanisms of causalgia, which results from a partial injury to the peripheral nerve trunk, have been proposed, whether or not antidromic impulses from the injured neurons contribute... -
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- Sensitization of Cutaneous Nociceptors in Neuropathic Rats
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Shim B, Gwak YS, Yoon DM, Leem JW, Nam TS, Paik KS
- KMID: 1946654
- J Korean Pain Soc.
- 2002 Jun;15(1):32-42.
BACKGROUND: Peripheral nerve injury leads to neuropathic pain. Although it has been accepted that both peripheral and central processes may play a role in the pathophysiology of these sensory... -
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- Changes of Electrophysiologic Properties of Dorsal Root Ganglion Cells in Peripheral Nerve-injured Rats
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Chang SK, Chung SS, Leem JW, Eun JW, Yoon DM, Nam TS
- KMID: 1947094
- J Korean Pain Soc.
- 2003 Jun;16(1):23-32.
BACKGROUND: The neuropathic pain induced by peripheral nerve injury has been shown to be spontaneous, hyperalgesia and allodynia. If the neuropathic pain is related to the sympathetic system, it is... -
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- Suppression by Microinjection of Bicuculline into Brain Stem Nuclei of Dorsal Horn Neuron Responsiveness in Neuropathic Rats
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Leem JW, Choi Y, Lee JH, Nam TS, Paik KS
- KMID: 2104785
- J Korean Pain Soc.
- 1998 May;11(1):23-29.
BACKGROUND: The present study was conducted to investigate effects of mieroinjection of bicuculline, GABA-A receptor antagonist, into the brain stem nuclei on the dorsal horn neuron responsiveness in rats with an experimental... -
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- Effects of NO Synthase Inhibitor on Responsiveness of Dorsal Horn Neurons in Neuropathic Pain Animal Model
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Leem JW, Gwak YS, Chung SS, Lee KR, Yoon DM, Nam TS
- KMID: 2335877
- J Korean Pain Soc.
- 2000 Jun;13(1):19-30.
BACKGROUND: Partial nerve injury to a peripheral nerve may induce the development of neuropathic pain which is characterized by symptams such as spontaneous burning pain, allodynia and hyperalgesia. Though underlying mechanism has... -
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- A change of nitric oxide in rat DRG following Freund's Complete Adjuvant induced inflammtory pain
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Hwang SJ, Lee JH, Chung TJ, Hong HN, Leem JW, Hwang JH, Choi Y
- KMID: 2092722
- Korean J Anat.
- 2000 Apr;33(2):135-142.
It has been reported that injection of Freund's complete adjuvant (FCA) into the hindpaw of a rat induces inflammatory responses with accompanying pain behaviors. Signs of pain behaviors observed in... -
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- Effects of iontophoretically applied substance P, calcitonin gene-related peptide on excitability of dorsal horn neurones in rats
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Leem JW, Gwak YS, Lee EH, Chung SS, Kim YS, Nam TS
- KMID: 720590
- Yonsei Med J.
- 2001 Feb;42(1):74-83.
- doi: 10.3349/ymj.2001.42.1.74
Spontaneous pain, allodynia and hyperalgesia are well known phenomena following peripheral nerve or tissue injury, and it is speculated that secondary hyperalgesia and allodynia, are generally thought... -
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