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HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide

Shin NR, Kim SH, Ko JW, Park SH, Lee IC, Ryu JM, Kim JC, Shin IS

HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse...
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3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling

Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY

3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle...
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Role of mitogen-activated protein kinases and nuclear factor-kappa B in 1,3-dichloro-2-propanol-induced hepatic injury

Lee IC, Lee SM, Ko JW, Park SH, Shin IS, Moon C, Kim SH, Kim JC

In this study, the potential hepatotoxicity of 1,3-dichloro-2-propanol and its hepatotoxic mechanisms in rats was investigated. The test chemical was administered orally to male rats at 0, 27.5, 55, and...
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Evaluation of 2-week repeated oral dose toxicity of 100 nm zinc oxide nanoparticles in rats

Ko JW, Hong ET, Lee IC, Park SH, Park JI, Seong NW, Hong JS, Yun HI, Kim JC

The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnO(AE100[+])) nanoparticles (NPs) in Sprague-Dawley rats. ZnO(AE100[+]) NPs were administered to...
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Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-kappaB Pathways

Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC

This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines...
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Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats

Ko JW, Lee IC, Park SH, Moon C, Kang SS, Kim SH, Kim JC

We investigated the protective effects of pine bark extract (pycnogenol(R), PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1)...
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Protective effect of diallyl disulfide on cyclophosphamide-induced testicular toxicity in rats

Kim SH, Lee IC, Baek HS, Moon C, Kim SH, Kim JC

This study investigated the protective effects of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced testicular toxicity in male rats. DADS was gavaged to rats once daily for 3 days at 100...
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Cervical Myelopathy Secondary to Atlanto-occipital Assimilation: The Usefulness of the Simple Decompressive Surgery

Kim KR, Lee YM, Kim YZ, Cho YW, Kim JS, Kim KH, Lee IC

Atlanto-occipital assimilation is one of the most common osseous anomalies observed at the craniocervical junction. Most patients with atlas assimilation show no symptom, but some have neurological problems such as...
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Synergistic effect of melamine in combination with cyanuric acid on urinary tract toxicity in rats

Lee IC, Kim SH, Baek HS, Kang SS, Kim JC

  • KMID: 2055100
  • J Biomed Res.
  • 2013 Sep;14(3):145-153.
The present study investigated the urinary tract toxicity of melamine alone or in combination with cyanuric acid in rats. Male rats were orally administered melamine alone (800 mg/kg) or melamine...
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4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats

Yu WJ, Lee IC, Lee J, Lee SM, Kim SH, Baek HS, Moon C, Kim SH, Chung YH, Kim JC

  • KMID: 2312103
  • Lab Anim Res.
  • 2013 Mar;29(1):48-54.
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male...
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Spermatotoxic effects of alpha-chlorohydrin in rats

Kim SH, Lee IC, Lim JH, Moon C, Bae CS, Kim SH, Shin DH, Kim HC, Kim JC

  • KMID: 2312087
  • Lab Anim Res.
  • 2012 Mar;28(1):11-16.
This study was conducted to investigate the potential effects of alpha-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by...
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Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy

Lim JH, Kim SH, Lee IC, Moon C, Kim SH, Shin DH, Kim HC, Kim JC

  • KMID: 2380156
  • Environ Health Toxicol.
  • 2011 ;26(1):e2011006.
OBJECTIVES: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. METHODS: MWCNTs were orally administered to...
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Biological Activity and Single Oral Dose Toxicity of Dansam-samultang

Lee IC, Kim BH, Kim MK

In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Dansam-samultang to evaluate its use as a functional ingredient...
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Investigations of Samwhang-sasimtang Extracts on Biological Activities In Vitro and Vivo

Lee IC, Kim BH, Kim MK

In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Samwhang-sasimtang to evaluate its use as a functional ingredient...
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Adenocarcinoma Arising from Heterotopic Gastric Mucosa in Cervical Esophagus: A Case Report

Hong YO, Hwang JE, Lee IC, Lee JH, Park SI, Cho KJ

  • KMID: 1163283
  • Korean J Pathol.
  • 2008 Feb;42(1):33-36.
Heterotopic gastric mucosa (HGM) of the upper esophagus, referred as "cervical inlet patch (CIP)", is a benign lesion that is present in 3.8-10% of the adult population. Adenocarcinomas arising from...
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Validation of Scoring System for Survival Prediction in Terminal Cancer Patients in Korea

Lee IC, Kim CK, Suh SY, Kim YS, Cho KH, Kang HC, Youn BB

  • KMID: 1987564
  • J Korean Acad Fam Med.
  • 2007 Sep;28(9):682-689.
BACKGROUND: Accurate prediction of survival in terminal cancer patients is important for planning effective palliative care. But, the prediction of survival most often relies on the physicians' prediction. Recently, simple...
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Anterior and Posterior Stabilization by One Stage Posterolateral Approach in the Unstable Fracture of Thoracolumbar and Lumbar Spine

Lee YM, Cho YW, Kim JS, Kim KH, Lee IC, Bae SD

  • KMID: 2067245
  • J Korean Neurosurg Soc.
  • 2006 Jul;40(1):22-27.
OBJECTIVE: The purpose of this study is to investigate the clinical results of anterior and posterior stabilization by one stage posterolateral approach for the unstable fracture of thoracolumbar and lumbar...
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Anterior Cervical Interbody Fusion with the Carbon Composite Osta-Pek Frame Cage in Degenerative Cervical Diseases

Han KW, Kim JS, Kim KH, Cho YW, Lee IC, Bae SD

  • KMID: 1817915
  • J Korean Neurosurg Soc.
  • 2005 Jun;37(6):422-426.
OBJECTIVE: Different types of interbody fusion cages are available for use in the surgical treatment of degenerative cervical diseases. The purpose of this study is to assess the technical feasibility,...
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Endoscopic Surgery for Pituitary Tumor

Kim DH, Kim KH, Cho YW, Kim JS, Lee IC, Bae SD

  • KMID: 1817822
  • J Korean Neurosurg Soc.
  • 2005 Jan;37(1):20-24.
OBJECTIVE: The purpose of this study is to assess the efficacy and advantages of an endoscopic endonasal approach for the treatment of pituitary tumors. METHODS: We retrospectively analyzed the records...
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Epidermal Growth Factor Receptor (EGFR) Expression in Operable Non-small Cell Lung Carcinoma

Ahn JH, Kim SW, Hong SM, Suh C, Kim WK, Lee IC, Lee JS

This study was performed to assay the expression of epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC), and to investigate the relationship between EGFR status and various...
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