- HemoHIM, a herbal preparation, alleviates airway inflammation caused by cigarette smoke and lipopolysaccharide
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Shin NR, Kim SH, Ko JW, Park SH, Lee IC, Ryu JM, Kim JC, Shin IS
- KMID: 2375271
- Lab Anim Res.
- 2017 Mar;33(1):40-47.
- doi: 10.5625/lar.2017.33.1.40
HemoHIM, herbal preparation has designed for immune system recovery. We investigated the anti-inflammatory effect of HemoHIM on cigarette smoke (CS) and lipopolysaccharide (LPS) induced chronic obstructive pulmonary disease (COPD) mouse... -
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- 3-Deoxysappanchalcone Promotes Proliferation of Human Hair Follicle Dermal Papilla Cells and Hair Growth in C57BL/6 Mice by Modulating WNT/β-Catenin and STAT Signaling
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Kim YE, Choi HC, Lee IC, Yuk DY, Lee H, Choi BY
- KMID: 2374610
- Biomol Ther.
- 2016 Nov;24(6):572-580.
- doi: 10.4062/biomolther.2016.183
3-Deoxysappanchalcone (3-DSC) has been reported to possess anti-allergic, antiviral, anti-inflammatory and antioxidant activities. In the present study, we investigated the effects of 3-DSC on the proliferation of human hair follicle... -
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- Role of mitogen-activated protein kinases and nuclear factor-kappa B in 1,3-dichloro-2-propanol-induced hepatic injury
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Lee IC, Lee SM, Ko JW, Park SH, Shin IS, Moon C, Kim SH, Kim JC
- KMID: 2312151
- Lab Anim Res.
- 2016 Mar;32(1):24-33.
- doi: 10.5625/lar.2016.32.1.24
In this study, the potential hepatotoxicity of 1,3-dichloro-2-propanol and its hepatotoxic mechanisms in rats was investigated. The test chemical was administered orally to male rats at 0, 27.5, 55, and... -
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- Evaluation of 2-week repeated oral dose toxicity of 100 nm zinc oxide nanoparticles in rats
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Ko JW, Hong ET, Lee IC, Park SH, Park JI, Seong NW, Hong JS, Yun HI, Kim JC
- KMID: 2312131
- Lab Anim Res.
- 2015 Sep;31(3):139-147.
- doi: 10.5625/lar.2015.31.3.139
The aim of this study was to verify subacute oral dose toxicity of positively charged 100 nm zinc oxide (ZnO(AE100[+])) nanoparticles (NPs) in Sprague-Dawley rats. ZnO(AE100[+]) NPs were administered to... -
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- Diallyl Disulfide Prevents Cyclophosphamide-Induced Hemorrhagic Cystitis in Rats through the Inhibition of Oxidative Damage, MAPKs, and NF-kappaB Pathways
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Kim SH, Lee IC, Ko JW, Moon C, Kim SH, Shin IS, Seo YW, Kim HC, Kim JC
- KMID: 2380352
- Biomol Ther.
- 2015 Mar;23(2):180-188.
- doi: 10.4062/biomolther.2014.126
This study investigated the possible effects and molecular mechanisms of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced hemorrhagic cystitis (HC) in rats. Inflammation response was assessed by histopathology and serum cytokines... -
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- Protective effects of pine bark extract against cisplatin-induced hepatotoxicity and oxidative stress in rats
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Ko JW, Lee IC, Park SH, Moon C, Kang SS, Kim SH, Kim JC
- KMID: 1737419
- Lab Anim Res.
- 2014 Dec;30(4):174-180.
- doi: 10.5625/lar.2014.30.4.174
We investigated the protective effects of pine bark extract (pycnogenol(R), PYC) against cisplatin-induced hepatotoxicity and oxidative stress in rats. Twenty-four male rats were divided into the following four groups: (1)... -
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- Protective effect of diallyl disulfide on cyclophosphamide-induced testicular toxicity in rats
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Kim SH, Lee IC, Baek HS, Moon C, Kim SH, Kim JC
- KMID: 1716215
- Lab Anim Res.
- 2013 Dec;29(4):204-211.
- doi: 10.5625/lar.2013.29.4.204
This study investigated the protective effects of diallyl disulfide (DADS) against cyclophosphamide (CP)-induced testicular toxicity in male rats. DADS was gavaged to rats once daily for 3 days at 100... -
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- Cervical Myelopathy Secondary to Atlanto-occipital Assimilation: The Usefulness of the Simple Decompressive Surgery
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Kim KR, Lee YM, Kim YZ, Cho YW, Kim JS, Kim KH, Lee IC
- KMID: 2140293
- Korean J Spine.
- 2013 Sep;10(3):189-191.
- doi: 10.14245/kjs.2013.10.3.189
Atlanto-occipital assimilation is one of the most common osseous anomalies observed at the craniocervical junction. Most patients with atlas assimilation show no symptom, but some have neurological problems such as... -
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- Synergistic effect of melamine in combination with cyanuric acid on urinary tract toxicity in rats
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Lee IC, Kim SH, Baek HS, Kang SS, Kim JC
- KMID: 2055100
- J Biomed Res.
- 2013 Sep;14(3):145-153.
The present study investigated the urinary tract toxicity of melamine alone or in combination with cyanuric acid in rats. Male rats were orally administered melamine alone (800 mg/kg) or melamine... -
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- 4-Week repeated oral dose toxicity study of 1,4-dichlorobutane in rats
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Yu WJ, Lee IC, Lee J, Lee SM, Kim SH, Baek HS, Moon C, Kim SH, Chung YH, Kim JC
- KMID: 2312103
- Lab Anim Res.
- 2013 Mar;29(1):48-54.
The present study investigated the potential subacute toxicity of 1,4-dichlorobutane by a 4-week repeated oral dose in Sprague-Dawley rats. The test article was administered once daily by gavage to male... -
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- Spermatotoxic effects of alpha-chlorohydrin in rats
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Kim SH, Lee IC, Lim JH, Moon C, Bae CS, Kim SH, Shin DH, Kim HC, Kim JC
- KMID: 2312087
- Lab Anim Res.
- 2012 Mar;28(1):11-16.
This study was conducted to investigate the potential effects of alpha-chlorohydrin (ACH) on epididymal function and antioxidant system in male rats. The test chemical was administered to male rats by... -
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- Evaluation of Maternal Toxicity in Rats Exposed to Multi-Wall Carbon Nanotubes during Pregnancy
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Lim JH, Kim SH, Lee IC, Moon C, Kim SH, Shin DH, Kim HC, Kim JC
- KMID: 2380156
- Environ Health Toxicol.
- 2011 ;26(1):e2011006.
OBJECTIVES: The present study investigated the potential adverse effects of multi-wall carbon nanotubes (MWCNTs) on pregnant dams and embryonic development following maternal exposure in rats. METHODS: MWCNTs were orally administered to... -
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- Biological Activity and Single Oral Dose Toxicity of Dansam-samultang
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Lee IC, Kim BH, Kim MK
- KMID: 2114707
- Lab Anim Res.
- 2010 Dec;26(4):385-391.
- doi: 10.5625/lar.2010.26.4.385
In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Dansam-samultang to evaluate its use as a functional ingredient... -
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- Investigations of Samwhang-sasimtang Extracts on Biological Activities In Vitro and Vivo
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Lee IC, Kim BH, Kim MK
- KMID: 1458935
- Lab Anim Res.
- 2010 Mar;26(1):15-20.
- doi: 10.5625/lar.2010.26.1.15
In this study, we investigated the in vitro antioxidative effects, antimicrobial activities and single oral dose toxicity of the extracts from Samwhang-sasimtang to evaluate its use as a functional ingredient... -
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- Adenocarcinoma Arising from Heterotopic Gastric Mucosa in Cervical Esophagus: A Case Report
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Hong YO, Hwang JE, Lee IC, Lee JH, Park SI, Cho KJ
- KMID: 1163283
- Korean J Pathol.
- 2008 Feb;42(1):33-36.
Heterotopic gastric mucosa (HGM) of the upper esophagus, referred as "cervical inlet patch (CIP)", is a benign lesion that is present in 3.8-10% of the adult population. Adenocarcinomas arising from... -
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- Validation of Scoring System for Survival Prediction in Terminal Cancer Patients in Korea
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Lee IC, Kim CK, Suh SY, Kim YS, Cho KH, Kang HC, Youn BB
- KMID: 1987564
- J Korean Acad Fam Med.
- 2007 Sep;28(9):682-689.
BACKGROUND: Accurate prediction of survival in terminal cancer patients is important for planning effective palliative care. But, the prediction of survival most often relies on the physicians' prediction. Recently, simple... -
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- Anterior and Posterior Stabilization by One Stage Posterolateral Approach in the Unstable Fracture of Thoracolumbar and Lumbar Spine
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Lee YM, Cho YW, Kim JS, Kim KH, Lee IC, Bae SD
- KMID: 2067245
- J Korean Neurosurg Soc.
- 2006 Jul;40(1):22-27.
OBJECTIVE: The purpose of this study is to investigate the clinical results of anterior and posterior stabilization by one stage posterolateral approach for the unstable fracture of thoracolumbar and lumbar... -
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- Anterior Cervical Interbody Fusion with the Carbon Composite Osta-Pek Frame Cage in Degenerative Cervical Diseases
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Han KW, Kim JS, Kim KH, Cho YW, Lee IC, Bae SD
- KMID: 1817915
- J Korean Neurosurg Soc.
- 2005 Jun;37(6):422-426.
OBJECTIVE: Different types of interbody fusion cages are available for use in the surgical treatment of degenerative cervical diseases. The purpose of this study is to assess the technical feasibility,... -
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- Endoscopic Surgery for Pituitary Tumor
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Kim DH, Kim KH, Cho YW, Kim JS, Lee IC, Bae SD
- KMID: 1817822
- J Korean Neurosurg Soc.
- 2005 Jan;37(1):20-24.
OBJECTIVE: The purpose of this study is to assess the efficacy and advantages of an endoscopic endonasal approach for the treatment of pituitary tumors. METHODS: We retrospectively analyzed the records... -
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- Epidermal Growth Factor Receptor (EGFR) Expression in Operable Non-small Cell Lung Carcinoma
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Ahn JH, Kim SW, Hong SM, Suh C, Kim WK, Lee IC, Lee JS
- KMID: 2157681
- J Korean Med Sci.
- 2004 Aug;19(4):529-535.
- doi: 10.3346/jkms.2004.19.4.529
This study was performed to assay the expression of epidermal growth factor receptor (EGFR) in non-small cell lung carcinoma (NSCLC), and to investigate the relationship between EGFR status and various... -
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