- Leber's Hereditary Optic Neuropathy with Olivocerebellar Degeneration due to G11778A and T3394C Mutations in the Mitochondrial DNA
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Nakaso K, Adachi Y, Fusayasu E, Doi K, Imamura K, Yasui K, Nakashima
- KMID: 2287596
- J Clin Neurol.
- 2012 Sep;8(3):230-234.
- doi: 10.3988/jcn.2012.8.3.230
BACKGROUND: Leber's hereditary optic neuropathy (LHON) is a mitochondrial disorder with optic nerve atrophy. Although there are no other associated neurological abnormalities in most cases of LHON, cases of "LHON... -
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- Visual Prognosis of Leber's Hereditary Optic Neuropathy with T14484C Mitochondrial DNA Mutation in Koreans
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Kim MJ, Park SS, Hwang JM
- KMID: 2215258
- J Korean Ophthalmol Soc.
- 2012 Jan;53(1):151-156.
- doi: 10.3341/jkos.2012.53.1.151
PURPOSE: In order to evaluate the clinical features and visual prognosis of Leber's hereditary optic neuropathy (LHON) associated with T14484C mitochondrial DNA (mtDNA) mutation in Korean patients. METHODS: To evaluate the... -
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- Leber's Hereditary Optic Neuropathy in a Patient Diagnosed With Normal Tension Glaucoma: A Case Report
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Lee S, Choi J, Jang JW, Kim DM, Kim SJ
- KMID: 2214149
- J Korean Ophthalmol Soc.
- 2011 Jan;52(1):122-127.
- doi: 10.3341/jkos.2011.52.1.122
PURPOSE: Leber's hereditary optic neuropathy (LHON) is caused by point mutations in mitochondrial DNA. The authors report a case of a middle-aged man with genetically confirmed LHON, combined with bilateral... -
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- Leber's Hereditary Optic Neuropathy with Mitochondrial DNA 11778 Mutation Presenting with Various Types of Seizures
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Kim KS, Moon JS, Lee JH, Ha SW, Kang SJ, Kim MJ, Kim JK, Yoo BG
- KMID: 2065616
- J Korean Neurol Assoc.
- 2006 Oct;24(5):498-502.
Leber's hereditary optic neuropathy (LHON) is a mitochondrial genetic disease characterized by acute or subacute visual loss associated with other neurologic diseases. We report a man with LHON caused by... -
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- Ondine's Curse Consequent to Recurrent Respiratory Failure in a Man with Leber Hereditary Optic Neuropathy
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Ha S, An SG, Lee SA
- KMID: 2343097
- J Korean Neurol Assoc.
- 2004 Aug;22(4):414-417.
Leber's hereditary optic neuropathy (LHON) is a disease due to mitochondrial DNA mutations. We report a man with LHON, who presented with four episodes of respiratory failure. In the last... -
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- Molecular Genetic Study on Primary and Secondary Mitochondrial DNA Mutations of Leber's Hereditary Optic Neuropathy in Koreans
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Hwang JM, Kim JY, Ko HS, Park SS, Chang BL
- KMID: 2022104
- J Korean Ophthalmol Soc.
- 2003 May;44(5):1153-1158.
PURPOSE: In order to evaluate the spectrum of mitochondrial DNA (mtDNA) mutations in the patients with suspected Leber's hereditary optic neuropathy (LHON). METHODS: We investigated 14 primary mtDNA mutations at... -
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- Leber's Hereditary Optic Neuropathy with Dystonia Caused by mtDNA 11778 Mutation
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Choi EJ, Lee SA, Ha JH, Ahn HS
- KMID: 2186058
- J Korean Neurol Assoc.
- 2000 Mar;18(2):244-248.
Several mtDNA mutations have been reported in Leber's hereditary optic neuropathy (LHON) associated with dystonia since it was identified as having the 14459 mutation. We report a patient with LHON... -
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- A Case of Leber's Hereditary Optic Nouropathy Showing 11778 Point Mutation of Mitochondrial DNA
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Jung YS, Park SK, Lee SY, Hah JS, Park MY, Lee SJ, Lee J
- KMID: 1969409
- Yeungnam Univ J Med.
- 1999 Jun;16(1):114-118.
- doi: 10.12701/yujm.1999.16.1.114
Leber's hereditary optic neuropathy(LHON) is an optic nerve disease that causes blindness and is associated with maternally inherited mitochondrial DNA(mt DNA) mutations. The most common mitochondrial DNA mutation among LHON... -
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- Optic Neuropathy in Koreans I. Leber's Hereditary Optic Neuropathy
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Kim SJ, Hwang JM, Chang BL, Park SS, Shin S, Yoon KY, Jung YC
- KMID: 2336720
- J Korean Ophthalmol Soc.
- 1998 Sep;39(9):2152-2159.
No abstract available. -
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- Leber's hereditary optic neuropathy(LHON) and leber's plus with mtDNA 11778 mutation: Clinical manifestations and a genealogic study
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Kwon SU, Hwang JM, Park HW, Kang DW, Koo JS, Lee KW, Roh JK
- KMID: 2442960
- J Korean Neurol Assoc.
- 1997 Apr;15(2):331-339.
Leber's hereditary optic neuropathy (LHON) is an important cause of bilateral optic neuropathy in youth and occasionally associated with other neurological abnormalities (Leber's plus). The authors recently found out one... -
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- Carbon monoxide poisoning as an epigenetic factor for Leber's hereditary optic neuropathy
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Hwang JM, Park HW
- KMID: 1735169
- Korean J Ophthalmol.
- 1996 Dec;10(2):122-123.
- doi: 10.3341/kjo.1996.10.2.122
A 45-year-old Korean woman visited our hospital complaining of poor vision after carbon monoxide (CO) poisoning. We have confirmed the presence of a point mutation at position 11778 in the... -
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- Clinical Manifestations of Leber's Hereditary Optic Neuropathy with 11778 mtDNA Mutation
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Kim SJ, Hwang JM, Park HW
- KMID: 2123512
- J Korean Ophthalmol Soc.
- 1996 Aug;37(8):1389-1396.
Leber's hereditary optic neuropathy is caused by a single nucleotide change in the mitochondrial deoxynucleic acid(mtDNA) and accounts for 30% of bilateral optic atrophy of unknown etiology. The authors found... -
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- A Mitochondrial Mutation in Leber's Hereditary Optic Neuropathy
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Hwang JM, Park HW
- KMID: 2205183
- J Korean Ophthalmol Soc.
- 1995 Dec;36(12):2218-2224.
Leber's hereditary optic neuropathy is caused by a single nucleotide change in the mitochondrial deoxynucleic acid(mtDNA). We identified a single guanine to adenine transition mutation in the mitochondrial DNA at... -
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