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5 results

Age-dependent changes of p53 and p63 immunoreactivities in the mouse hippocampus

Lee TK, Park YE, Park CW, Kim B, Lee JC, Park JH, Lee HA, Won MH, Ahn JH

  • Lab Anim Res.
  • 2019 Oct;35(3):140-147.
  • doi: 10.1186/s42826-019-0022-0
P53 and its family member p63 play important roles in cellular senescence and organismal aging. In this study, p53 and p63 immunoreactivity were examined in the hippocampus of young, adult...
Lipopolysaccharide induces neuroglia activation and NF-κB activation in cerebral cortex of adult mice

Kang JB, Park DJ, Shah MA, Kim MO, Koh PO

  • Lab Anim Res.
  • 2019 Oct;35(3):132-139.
  • doi: 10.1186/s42826-019-0018-9
Lipopolysaccharide (LPS) acts as an endotoxin, releases inflammatory cytokines, and promotes an inflammatory response in various tissues. This study investigated whether LPS modulates neuroglia activation and nuclear factor kappa B...
Resveratrol modulates the Akt/GSK-3β signaling pathway in a middle cerebral artery occlusion animal model

Park DJ, Kang JB, Shah FA, Koh PO

  • Lab Anim Res.
  • 2019 Oct;35(3):124-131.
  • doi: 10.1186/s42826-019-0019-8
Cerebral ischemia is a major cause of neurodegenerative disease. It induces neuronal vulnerability and susceptibility, and leads to neuronal cell death. Resveratrol is a polyphenolic compound that acts as an...
Comparison of responsiveness to cancer development and anti-cancer drug in three different C57BL/6N stocks

Kang MJ, Kim JE, Park JW, Choi HJ, Bae SJ, Kim KS, Jung YS, Cho JY, Hwang DY, Song HK

  • Lab Anim Res.
  • 2019 Oct;35(3):114-123.
  • doi: 10.1186/s42826-019-0015-z
In our efforts to understand the systemic features of tumors, the importance of animal models is increasing due to the recent growth in the development of immunotherapy and targeted therapies....
Comparison of toxic responses to acetaminophen challenge in ICR mice originating from different sources

Jeong TB, Kim JH, Kim SH, Lee S, Son SW, Lim Y, Cho JY, Hwang DY, Kim KS, Kwak JH, Jung YS

  • Lab Anim Res.
  • 2019 Oct;35(3):107-113.
  • doi: 10.1186/s42826-019-0017-x
Acetaminophen (APAP) is the most common antipyretic analgesic worldwide. However, APAP overdose causes severe liver injury, especially centrilobular necrosis, in humans and experimental animals. At therapeutic dosage, APAP is mainly...

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