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Role of PKG-L-type calcium channels in the antinociceptive effect of intrathecal sildenafil

Kim WM, Yoon MH, Cui JH

Sildenafil increases the cyclic guanosine monophosphate (cGMP) by inhibition of a phosphodiesterase 5, thereby leading to an antinociceptive effect. The increased cGMP may exert the effect on an L-type calcium...
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Relaxation Responses of Isolated Rabbit Seminal Vesicle to Polyamines

Myung SC, Lee SY, Kang GH, Keum EM, Lee MY, Kim SC

  • KMID: 2293954
  • Korean J Urol.
  • 2005 Feb;46(2):169-173.
PURPOSE: This study was designed to investigate the effects of polyamines on rabbit seminal vesicular contractility. MATERIALS AND METHODS: The polyamines; putrescine, spermidine and spermine, were added to deepithelized and precontracted...
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Nitric Oxide Synthase Mediates Carbon Monoxide-Induced Stimulation of L-type Calcium Currents in Human Jejunal Smooth Muscle Cells

Lim I, Yun J, Kim S, Myung S, Kim T, Bang H

  • KMID: 2285301
  • Korean J Physiol Pharmacol.
  • 2004 Jun;8(3):161-166.
Exogenous carbon monoxide (0.2%) increases L-type calcium (Ca2+) current in human jejunal circular smooth muscle cells. The stimulatory effect of carbon monoxide (CO) on L-type Ca2+ current is inhibited by...
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Effect of Glucose Concentrations on the Cell Proliferation and Expression of L-type Calcium Channel mRNA in Cultured Rat Aortic Vascular Smooth Muscle Cells

Cho YJ, Yoo HJ, Nam HW, Suh JY, Jeong IK, Ihm SH, Kim HK, Park CY, Yoo JM, Kim DM, Choi MG, Park SW

  • KMID: 1768002
  • J Korean Diabetes Assoc.
  • 2003 Jun;27(3):253-259.
BACKGROUND: Vascular smooth muscle cell (VSMC) proliferation is one of the major pathogenic mechanisms for atherosclerosis. It is known that L-type calcium channels play a role in VSMC proliferation in...
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The Effect of Carbon Monoxide on L-type Calcium Channel Currents in Human Intestinal Smooth Muscle Cells

Lim I

  • KMID: 1607521
  • Korean J Physiol Pharmacol.
  • 2003 Dec;7(6):357-362.
Carbon monoxide (CO) is low molecular weight oxide gas that is endogenously produced under physiological conditions and interacts with another gas, nitric oxide (NO), to act as a gastrointestinal messenger....
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Mechanisms of Motilin Action on Smooth Muscle of the Human Stomach

Shim SG, Rhee JC, Rhee PL, Choi KW, Jeon SK, Kang TM, Uhm DY, Lee JS, Sung IK, Kim HS

  • KMID: 1606490
  • Korean J Gastroenterol.
  • 2002 Jan;39(1):4-12.
Background/Aims: Motilin is an intestinal peptide that stimulates the contraction of gut smooth muscle. A discrepancy exists between the in vivo (neurally mediated) and in vitro (direct action on a...
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