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Establishment of Hepatocellular Cancer Induced Pluripotent Stem Cells Using a Reprogramming Technique

Kim HJ, Jeong J, Park S, Jin YW, Lee SS, Lee SB, Choi D

BACKGROUND/AIMS: Cancer is known to be a disease by many factors. However, specific results of reprogramming by pluripotency-related transcription factors remain to be scarcely reported. Here, we verified potential effects...
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Identification of DNA methylation associated gene signatures in endometrial cancer via integrated analysis of DNA methylation and gene expression systematically

Men C, Chai H, Song X, Li Y, Du H, Ren Q

OBJECTIVE: Endometrial cancer (EC) is a common gynecologic cancer worldwide. However, the pathogenesis of EC has not been epigenetically elucidated. Here, this study aims to describe the DNA methylation profile...
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Replication of the results of genome-wide and candidate gene association studies on telomere length in a Korean population

Do SK, Yoo SS, Choi YY, Choi JE, Jeon HS, Lee WK, Lee SY, Lee J, Cha SI, Kim CH, Park JY

BACKGROUND/AIMS: A number of genome-wide and candidate gene association studies have identified polymorphisms associated with telomere length in Caucasian populations. This study was conducted to determine the impacts of 17...
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Kruppel-like factor 4 mediates lysophosphatidic acid-stimulated migration and proliferation of PC3M prostate cancer cells

Shin SH, Kwon YW, Heo SC, Jeong GO, Kim BR, Seo EJ, Kim JH

Prostate cancer is the most frequently diagnosed malignancy and the second leading cause of cancer mortality among men in the United States. Accumulating evidence suggests that lysophosphatidic acid (LPA) serves...
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Constitutive stabilization of hypoxia-inducible factor alpha selectively promotes the self-renewal of mesenchymal progenitors and maintains mesenchymal stromal cells in an undifferentiated state

Park IH, Kim KH, Choi HK, Shim JS, Whang SY, June Hahn , Kwon OJ, Oh IH

  • KMID: 2154263
  • Exp Mol Med.
  • 2013 Sep;45(9):e44.
With the increasing use of culture-expanded mesenchymal stromal cells (MSCs) for cell therapies, factors that regulate the cellular characteristics of MSCs have been of major interest. Oxygen concentration has been...
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KLF4 Expression Correlates with the Degree of Differentiation in Colorectal Cancer

Hu R, Zuo Y, Zuo L, Liu C, Zhang S, Wu Q, Zhou Q, Gui S, Wei W, Wang Y

  • KMID: 2135086
  • Gut Liver.
  • 2011 Jun;5(2):154-159.
BACKGROUND/AIMS: Kruppel-like factor 4 (KLF4) is an epithelial-specific transcription factor primarily expressed in the gastrointestinal tract that mediates growth arrest in the colonic epithelium. We tried to find whether KLF4...
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