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KOBIO, the First Web-based Korean Biologics Registry Operated With a Unified Platform Among Distinct Disease Entities

Kim J, Koh JH, Choi SJ, Jeon CH, Kwok SK, Kim SK, Choi CB, Lee J, Lee C, Nam EJ, Park YB, Lee SS, Kim TH, Park SH, Choe JY, Koh EM, Yoo DH, Song YW, Kim HA, Shin K

The KOrean College of Rheumatology BIOlogics and targeted therapy (KOBIO) registry is a nationwide observational cohort that captures detailed data on exposure of patients to biologic and targeted synthetic disease-modifying...
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The Effects of Sex and Estrogen on Radiographic Progression of Ankylosing Spondylitis in Korean Patients

Jeong H, Bae EK, Hwang J, Park EJ, Lee J, Jeon CH, Koh EM, Cha HS

Objective. Ankylosing spondylitis (AS) is a chronic inflammatory disease with obvious male preponderance. Males show more severe radiographic manifestations compared with females. This study aimed to evaluate the effects of...
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Rheumatoid Factor Positivity is Associated with Lower Bone Mass in Korean Male Health Examinees without Clinically Apparent Arthritis

Hwang J, Ahn JK, Lee J, Koh EM, Cha HS

OBJECTIVE: This cross-sectional study aimed to investigate the association between rheumatoid factor (RF) positivity and bone mineral density (BMD) in male Korean subjects without any history of joint disease. METHODS: Of...
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Peripapillary Retinal Nerve Fiber Layer Thicknesses Did Not Change in Long-term Hydroxychloroquine Users

Lee EJ, Kim SJ, Han JC, Eo DR, Lee MG, Ham DI, Kang SW, Kee C, Lee J, Cha HS, Koh EM

PURPOSE: To evaluate changes in the peripapillary retinal nerve fiber layer (RNFL) thicknesses using spectral-domain optical coherence tomography (SD-OCT) in hydroxychloroquine (HCQ) users. METHODS: The medical records of HCQ users were...
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Rapid onset of efficacy predicts response to therapy with certolizumab plus methotrexate in patients with active rheumatoid arthritis

Kang YM, Park YE, Park W, Choe JY, Cho CS, Shim SC, Bae SC, Suh CH, Cha HS, Koh EM, Song YW, Yoo B, Lee SS, Park MC, Lee SH, Arendt C, Koetse W, Lee SK

BACKGROUND/AIMS: The objective of this study was to determine the efficacy and safety of add-on therapy with certolizumab pegol (CZP) in active rheumatoid arthritis (RA) patients of a single ethnicity. METHODS:...
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Drug survival of tumor necrosis factor α inhibitors in patients with ankylosing spondylitis in Korea

Jeong H, Eun YH, Kim IY, Kim H, Ahn JK, Lee J, Koh EM, Cha HS

BACKGROUND/AIMS: To evaluate drug survival of the tumor necrosis factor α inhibitors (TNFi) and risk factors for the drug discontinuation in patients with ankylosing spondylitis (AS). METHODS: We retrospectively evaluated 487...
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Performance of an Automated Fluorescence Antinuclear Antibody Image Analyzer

Yoo IY, Oh JW, Cha HS, Koh EM, Kang ES

BACKGROUND: The gold standard for antinuclear antibody (ANA) screening is the indirect immunofluorescence (IIF) assay with human epithelial cells (HEp-2). However, a number of substantial disadvantages of manual IIF assays...
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Characteristics of hip involvement in patients with ankylosing spondylitis in Korea

Jeong H, Eun YH, Kim IY, Kim H, Lee J, Koh EM, Cha HS

BACKGROUND/AIMS: To evaluate the clinical course of hip arthritis and the risk factors for hip joint replacement in patients with ankylosing spondylitis (AS). METHODS: In this retrospective analysis, we evaluated 488...
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Pituitary Granulomatosis with Polyangiitis Presenting with Central Diabetes Insipidus

Kim IY, Lee S, Kwon HJ, Lee K, Yoo KH, Cha HS, Koh EM, Lee J

We report on a case of limited form of granulomatosis with polyangiitis (GPA) with pituitary involvement which presented with central diabetes insipidus. This rare form of GPA has not been...
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Predictive factors of radiographic progression in ankylosing spondylitis

Kim H, Lee J, Ahn JK, Hwang J, Park EJ, Jeong H, Cha HS, Koh EM

BACKGROUND/AIMS: The course of ankylosing spondylitis (AS) is rather variable, and the factors that predict radiographic progression remain largely obscure. In this study, we tried to determine the clinical factors...
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Clinical characteristics of male and female Korean patients with systemic lupus erythematosus: a comparative study

Hwang J, Lee J, Ahn JK, Park EJ, Cha HS, Koh EM

BACKGROUND/AIMS: To compare the clinical characteristics and outcomes of systemic lupus erythematosus between male and female Korean patients. METHODS: A retrospective analysis was performed at a single tertiary hospital from August...
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Three Cases of Overlap Syndrome Consisting of Systemic Sclerosis and Rheumatoid Arthritis

Lee S, Yoo KH, Lee K, Kim IY, Kwon HJ, Jeong H, Koh EM

Overlap syndrome is defined as a disease entity that fulfills the classification criteria of at least two different rheumatologic diseases simultaneously. Overlap of systemic sclerosis (SSc) and rheumatoid arthritis (RA)...
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Epidemiology of Polymyalgia Rheumatica in Korea

Kim IY, Seo GH, Lee S, Jeong H, Kim H, Lee J, Koh EM, Cha HS

OBJECTIVE: Polymyalgia rheumatica is a chronic inflammatory disease that affects people older than 50 years of age. The diagnosis is made based on clinical features, and the current standard of...
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Prediction for TNF Inhibitor Users in RA Patients According to Reimbursement Criteria Based on DAS28

Won S, Sung YK, Cho SK, Choi CB, Koh EM, Kim SK, Kim J, Kim TH, Kim HA, Nah SS, Bang SY, Suh CH, Shim SC, Yoo DH, Yoon BY, Lee SH, Lee SW, Lee SS, Lee YA, Lee J, Lee J, Lee HS, Lim MK, Jun JB, Jeon CH, Jung YO, Chung WT, Cha HS, Choe JY, Hong SJ, Bae SC

OBJECTIVE: The purpose of this study is to examine the difference between the numbers of patients in rheumatoid arthritis (RA) who are eligible to TNF inhibitors by the past Korean...
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The Urate-lowering Efficacy and Safety of Febuxostat in Korean Patients with Gout

Park SH, Song YW, Park W, Koh EM, Yoo B, Lee SK, Yoo DH, Lee YJ, Kim HA, Choi HJ, Kim HY, Jung HG

OBJECTIVE: To compare the urate-lowering efficacy and the safety of febuxostat, allopurinol and placebo in Korean patients with gout for 4 weeks. METHODS: Subjects (n=182) with gout were randomized to febuxostat...
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Two Cases of Refractory Adult-Onset Still's Disease Responding to Anakinra

Oh JM, Kim H, Lee J, Ahn JK, Lee YS, Koh EM, Cha HS

  • KMID: 2264308
  • Korean J Med.
  • 2012 Apr;82(4):520-524.
Adult-onset Still's disease (AOSD) is a systemic inflammatory disorder with variable clinical features. The interleukin (IL)-1 receptor antagonist anakinra has been proposed as an alternative effective treatment in refractory AOSD....
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Correlation of DEFA1 Gene Copy Number Variation with Intestinal Involvement in Behcet's Disease

Ahn JK, Cha HS, Lee J, Jeon CH, Koh EM

Copy number variation has been associated with various autoimmune diseases. We investigated the copy number (CN) of the DEFA1 gene encoding alpha-defensin-1 in samples from Korean individuals with Behcet's disease...
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Pseudo-outbreak of Brevundimonas diminuta

Kim YH, Koh EM, Lee YW, Lee YK, Shin HB, Lee K

Brevundimonas diminuta is a lactose non-fermenting Gram-negative rod associated with infection in immunocompromised patients. In three patients from two general wards, B. diminuta was isolated in blood culture sample. The...
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Extracellular High-Mobility Group Box 1 is Increased in Patients with Behcet's Disease with Intestinal Involvement

Ahn JK, Cha HS, Bae EK, Lee J, Koh EM

High-mobility group box 1 (HMGB1) protein has been demonstrated to play an important role in chronic inflammatory diseases including rheumatoid arthritis, and systemic lupus erythematosus. This study investigated the association...
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Enthesitis in a Patient with Systemic Lupus Erythematosus: The First Case Report

Kim H, Lee J, Ahn JK, Hwang JW, Noh JW, Koh EM, Cha HS

  • KMID: 1966890
  • Korean J Med.
  • 2011 Feb;80(2):243-246.
We present the first case of enthesitis in the lumbar spine in a woman with systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). Enthesopathy is defined as pathological alterations at...
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