- The role of renal proximal tubule transport in the regulation of blood pressure
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Horita S, Nakamura M, Suzuki M, Satoh N, Suzuki A, Homma Y, Nangaku M
- KMID: 2409385
- Kidney Res Clin Pract.
- 2017 Mar;36(1):12-21.
- doi: 10.23876/j.krcp.2017.36.1.12
The electrogenic sodium/bicarbonate cotransporter 1 (NBCe1) on the basolateral side of the renal proximal tubule plays a pivotal role in systemic acid-base homeostasis. Mutations in the gene encoding NBCe1 cause... -
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- Adefovir-induced Fanconi syndrome associated with osteomalacia
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Park S, Kim WI, Cho DH, Kim YJ, Kim HS, Kim JH, Cha SK, Park KS, Lee JH, Lee SM, Lee EY
- KMID: 2428762
- Clin Mol Hepatol.
- 2018 Sep;24(3):339-344.
- doi: 10.3350/cmh.2017.0009
Fanconi syndrome is a dysfunction of the proximal renal tubules that results in impaired reabsorption and increased urinary loss of phosphate and other solutes. The pathophysiology of drug-induced Fanconi syndrome... -
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- Reversible Proximal Renal Tubular Dysfunction after One-Time Ifosfamide Exposure
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Kim YI, Yoon JY, Hwang JE, Shim HJ, Bae WK, Cho SH, Chung IJ
- KMID: 2165959
- Cancer Res Treat.
- 2010 Dec;42(4):244-246.
The alkylating agent ifosfamide is an anti-neoplastic used to treat various pediatric and adult malignancies. Its potential urologic toxicities include glomerulopathy, tubulopathy and hemorrhagic cystitis. This report describes a case... -
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- Gentamicin Induced Apoptosis of Renal Tubular Epithelial (LLC-PK1) Cells
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Choi KH, Kim TI, Chong DL, Lee HY, Han DS
- KMID: 759521
- Korean J Intern Med.
- 2000 Dec;15(3):218-223.
Nephrotoxicity is a major limiting factor in the use of aminoglycoside antibiotics, the mechanisms for which are still speculative. To clarify the mechanisms of renal tubular cell death induced by... -
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- Increased Expression of Heat Shock Protein 72 Protects Renal Proximal Tubular Cells from Gentamicin-induced Injury
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Wang Z, Liu L, Mei Q, Liu L, Ran Y, Zhang R
- KMID: 1781913
- J Korean Med Sci.
- 2006 Oct;21(5):904-910.
- doi: 10.3346/jkms.2006.21.5.904
The nephrotoxicity of gentamicin (GM) has been widely recognized. Heat shock protein 72 (HSP72) has been reported to be a cytoprotectant. However, its cytoprotective effect against GM induced kidney injury... -
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- Regulations of Bicarbonate Ions in Hypokalemic Rat Kidney
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Kim JH, Cho HJ, Bae MO, Park JJ, Ahn KY
- KMID: 2224496
- Korean J Anat.
- 2004 Aug;37(4):337-345.
A number of acid-base or electrolyte disorders are associated with decreased or increased HCO3- reabsorption in the renal tubules. There has been a general agreement that potassium depletion induces and... -
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- A Case of Primary Hyperparathyroidism Associated with Proximal Renal Tubular Acidosis and Postoperative Hungry Bone Syndrome
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Han JH, Yoon KH, Cha BY, Son HY, Lee KW, Jung HO, Kim CS, Kang MI, Cho CS, Kim HY, Kang SK
- KMID: 2461472
- J Korean Soc Endocrinol.
- 1994 Jun;9(2):141-149.
Primary hyperparathyroidism is a generalezed disorder of calcium, phosphorus and bone metabolism due to an increased secretion of parathyroid hormone. Single parathyroid adenoma is the most common cause of primary... -
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- Prior Ischemic Treatment Renders Kidney Resistant to Subsequent Ischemia
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Park KM, Han HJ
- KMID: 1095370
- J Vet Sci.
- 2002 Jun;3(2):115-121.
Prior ischemia leads to resistance against subsequent ischemic insults. The mechanisms that underlie this adaptive response remain unidentified. Thus, we studied whether the reduced susceptibility of mice previously subjected to... -
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- Beta ig-h3 promotes renal proximal tubular epithelial cell adhesion, migration and proliferation through the interaction with alpha3beta1 integrin
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Park SW, Bae JS, Kim KS, Park SH, Lee BH, Choi JY, Park JY, Ha SW, Kim YL, Kwon TH, Kim IS, Park RW
- KMID: 1097102
- Exp Mol Med.
- 2004 Jun;36(3):211-219.
Betaig-h3 (betaig-h3) is a secretory protein composed of fasciclin I-like repeats containing sequences that allows binding of integrins and glycosaminoglycans in vivo. Expression of betaig-h3 is responsive to TGF-beta and... -
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- Crystals in a patient with asymptomatic proteinuria
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Lim JH, Yhim HY, Cha EJ, Park MH, Kang KP
- KMID: 2070146
- Korean J Intern Med.
- 2014 Nov;29(6):838-839.
- doi: 10.3904/kjim.2014.29.6.838
No abstract available. -
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- Effect of Perinatal Asphyxia and Gentamicin on Urinary B2-microglobulin Concentration and Renal Function in Fullterm Neonates
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Hann HJ, Lee SJ
- KMID: 1879422
- J Korean Pediatr Soc.
- 1994 Jul;37(7):976-985.
Perinatal asphyxia can cause ischemic injury to immature kidney of neonates. Proximal renal tubule is the most sensitive area, showing various manifestations ranging from mild reversible injury to irreversible tubular... -
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- A Case of IgA kappa Light Chain Deposition Disease and Combined Adult Fanconi Syndrome with Auer rod-like Intracytoplasmic Inclusions in Plasma Cells and Proximal Renal Tubular Cells
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Kahng J, Kim J, Shin SJ, Han K
- KMID: 1781492
- Korean J Lab Med.
- 2007 Aug;27(4):248-252.
- doi: 10.3343/kjlm.2007.27.4.248
We report a case of IgA kappa light chain deposition disease and combined adult Fanconi syndrome with Auer rod-like intracytoplasmic inclusions in plasma cells and proximal renal tubular cells in... -
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- A Case of Cystinuria with Multiple Renal Stones in an 8-month-old Girl
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Kang EG, Lee JH, Lee BH, Kim GH, Park YS
- KMID: 2098920
- J Korean Soc Pediatr Nephrol.
- 2013 Oct;17(2):122-126.
Cystinuria is an autosomal recessive disease characterized by impaired transport of cystine and dibasic amino acids in the proximal renal tubule, resulting in the formation of cystine stones. It is... -
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- Familiarly Developed Vitamine D Resistant Rickets: Case Report
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Woo YK, Moon MS, Lee HD
- KMID: 2446577
- J Korean Orthop Assoc.
- 1984 Aug;19(4):723-729.
- doi: 10.4055/jkoa.1984.19.4.723
Rickets is a syndrome, characterized pathophysiologically by a failure of normal mineralization of bone and epiphyseal cartilage and clinically by skeletal deformity in growing children. The five principal causes of... -
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- Association of rOAT1 with Caveolin-1 in Rat Kidney
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Cha SH, Won YJ, Hwang JS, Suh CK
- KMID: 2253308
- Korean J Nephrol.
- 2008 Mar;27(2):175-185.
PURPOSE: A family of organic anion transporters (OAT) has been identified, and several isoforms have been reported. The regulatory mechanisms of OATs functions, however, still remain to be elucidated. The... -
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- Co-localization and interaction of organic anion transporter 1 with caveolin-2 in rat kidney
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Kwak JO, Kim HW, Oh KJ, Kim DS, Han KO, Cha SH
- KMID: 1056233
- Exp Mol Med.
- 2005 Jun;37(3):204-212.
The organic anion transporters (OAT) have recently been identified. Although the some transport properties of OATs in the kidney have been verified, the regulatory mechanisms for OAT's functions are still... -
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- Angiotensin III increases monocyte chemoattractant protein-1 expression in cultured human proximal tubular epithelial cells
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Kim HW, Kim YO, Yoon SA, Han JS, Chun HB, Kim YS
- KMID: 2373780
- Korean J Intern Med.
- 2016 Jan;31(1):116-124.
- doi: 10.3904/kjim.2016.31.1.116
BACKGROUND/AIMS: We investigated whether angiotensin III (Ang III) is involved in monocyte recruitment through regulation of the chemokine monocyte chemoattractant protein-1 (MCP-1) in cultured human proximal tubular epithelial cells (HK-2... -
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- A Case of Hereditary Fructose Intolerance
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Kang EK, Yang HR, Seo JK, Bai SH, Jeong JY, Ko JS, Ha IS, Song JH, Wi KA, Shin YS
- KMID: 2335570
- J Korean Pediatr Soc.
- 2002 Jan;45(1):120-124.
Hereditary fructose intolerance(HFI) is an autosomal recessive disease caused by catalytic deficiency of aldolase B in which affected homozygotes develop hypoglycemia and abdominal symptoms after taking foods containing fructose. Chronic... -
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- -Melanocyte Stimulating Hormone (MSH) decreases cyclosporine A induced apoptosis in cultured human proximal tubular cells
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Jo SK, Lee SY, Han SY, Cha DR, Cho WY, Kim HK, Won NH
- KMID: 2157569
- J Korean Med Sci.
- 2001 Oct;16(5):603-609.
- doi: 10.3346/jkms.2001.16.5.603
The pathogenesis of chronic cyclosporine A (CsA) nephrotoxicity has not been elucidated, but apoptosis is thought to play an important role in CsA induced tubular atrophy. Recently Fas-Fas ligand system... -
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- Calcitonin induces connective tissue growth factor through ERK1/2 signaling in renal tubular cells
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Nakamura M, Ozaki T, Ishii A, Konishi M, Tsubota Y, Furui T, Tsuda H, Mori I, Ota K, Kakudo K
- KMID: 1123804
- Exp Mol Med.
- 2009 May;41(5):307-314.
- doi: 10.3858/emm.2009.41.5.034
Calcitonin (CT), a polypeptide hormone, plays important roles in a variety of physiological processes. CT has been used clinically to treat osteoporosis and humoral hypercalcemia of malignancy. In order to... -
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