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Performance Evaluation of the Autokit Total Ketone Bodies

Lee N, Ha C, Yun H, Woo K

In this study, the Autokit Total Ketone Bodies kit (Wako Pure Chemical, Japan), a total ketone measurement assay using an enzymatic method, was evaluated using a Roche Cobas e702 instrument...
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Evaluation of the Clinical Significance of Ketonuria

Jung HW, Park IK

BACKGROUND: Urine ketone test is commonly used to screen for diabetic ketoacidosis (DKA). Ketonuria also develops in patients with disease conditions other than DKA. However, the prevalence of DKA in...
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SGLT2 Inhibitors and Ketoacidosis: Pathophysiology and Management

Ku YH

Sodium-glucose cotransporter 2 inhibitors are antidiabetic drugs that increase urinary glucose excretion by inhibiting proximal tubular reabsorption of glucose in the kidney. Some sodium-glucose cotransporter 2 inhibitors have been shown...
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Protection of Hepatic Dysfunction during and after Hemorrhagic Shock with Intravenous Glutathione in Dogs

Yun AS, Choe YG, Kim YJ, Park JW, Shin CM, Park JY

During hemorrhagic shock, liver is susceptible to ischemia and decreased hepatic energy charge results in decreasing arterial ketone body ratio(AKBR). Reperfusion after hemorrhagic shock can greatly amplify the generation of...
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Euglycemic Diabetic Ketoacidosis When Reducing Insulin Dosage in Patients Taking Sodium Glucose Cotransporter 2 Inhibitor

Yi WJ, Kim SK, Youn SU, Kang N, Lee MW, Park SO

Sodium glucose cotransporter 2 (SGLT2) inhibitor has been recently reported of diabetic ketoacidosis due to accumulation of ketone bodies in patients with severe dehydration caused from such like diarrhea even...
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A Case of Guillain-Barre Syndrome Associated with Diabetic Ketoacidosis

Park KJ, Hahm JR, Lee L, Sung IS, Choi NC, Kwon OY, Lim BH

  • KMID: 2343028
  • J Korean Neurol Assoc.
  • 2002 Sep;20(5):558-560.
A 30-year-old man was admitted due to decreased mentality. He was diagnosed as a diabetic ketoacidosis by hyperglycemia, metabolic acidosis, and positive urinary ketone bodies. Two weeks later, despite the...
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A Rare Cause of Life-Threatening Ketoacidosis: Novel Compound Heterozygous OXCT1 Mutations Causing Succinyl-CoA:3-Ketoacid CoA Transferase Deficiency

Kim YA, Kim SH, Cheon CK, Kim YM

Succinyl-CoA:3-ketoacid CoA transferase (SCOT) deficiency is a rare inborn error of ketone body utilization, characterized by episodic or permanent ketosis. SCOT deficiency is caused by mutations in the OXCT1 gene,...
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Evaluation of the T-KB-H and 3-HB Kits for the Measurement of Serum Ketone and beta-Hydroxybutyric Acid

Lee K, Jun SH, Lee KW, Han M, Song SH, Park KU, Song J

  • KMID: 2312238
  • Lab Med Online.
  • 2014 Jan;4(1):22-27.
BACKGROUND: Diabetes mellitus and alcohol consumption are the most common causes of ketoacidosis in adults. Recently, beta-hydroxybutyric acid (betaHBA) was reported to be a potential serum biomarker in the diagnosis...
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Effects of Low-carbohydrate and High-fat Diet Supplemented with Ketogenic Drink on Cognitive Function and Physical Performance in the Elderly at High Risk for Dementia

Kim EJ, Park JS, Choi WS, Park YK

OBJECTIVES: Reduced glucose utilization in the main parts of the brain involved in memory is a major cause of Alzheimer's disease, in which ketone bodies are used as the only...
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A novel mutation of ABCC8 gene in a patient with diazoxide-unresponsive congenital hyperinsulinism

Park JS, Lee HJ, Park CH

Congenital hyperinsulinism (CHI) is a rare condition that can cause irreversible brain damage during the neonatal period owing to the associated hypoglycemia. Hypoglycemia in CHI occurs secondary to the dysregulation...
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Role of Pyruvate Dehydrogenase Kinase 4 in Regulation of Blood Glucose Levels

Jeoung NH, Harris RA

In the well-fed state a relatively high activity of the pyruvate dehydrogenase complex (PDC) reduces blood glucose levels by directing the carbon of pyruvate into the citric acid cycle. In...
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Fulminant Type 1 Diabetes with Robust Recovery in Insulin Secretion in a Pregnant Woman as an Initial Manifestation of Third-Trimester Intrauterine Fetal Death

Seo MH, Han H, Jeong JY, Chang JY, Jung SY

Fulminant type 1 diabetes mellitus (FT1DM) is a clinical entity in which the process of beta-cell destruction and subsequent progression of hyperglycemia and ketoacidosis are extremely rapid. A 34-year-old woman...
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Reduction of Food Intake by Fenofibrate is Associated with Cholecystokinin Release in Long-Evans Tokushima Rats

Park MK, Han Y, Kim MS, Seo E, Kang S, Park SY, Koh H, Kim DK, Lee HJ

Fenofibrate is a selective peroxisome proliferator-activated receptor alpha (PPARalpha) activator and is prescribed to treat hyperlipidemia. The mechanism through which PPARalpha agonists reduce food intake, body weight, and adiposity remains...
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An Unusual Presentation of Diabetic Ketoacidosis in Familial Hajdu-Cheney Syndrome: A Case Report

Lee GH, An SY, Sohn YB, Jeong SY, Chung YS

A 21-year-old man with diabetic ketoacidosis (DKA) displayed short and clubbed fingers and marked eyebrow, which are typical of Hajdu-Cheney Syndrome (HCS). Laboratory findings confirmed type 1 diabetes mellitus (DM)....
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A Study on the Liver Toxicity Induced by Ketogenic Diet in Rats

Moon JS, Kim DW

  • KMID: 2177040
  • J Korean Child Neurol Soc.
  • 2002 Nov;10(2):213-218.
PURPOSE: Ketogenic diet(KD) remains a therapy in search of explanation although it is an established treatment for patients with intractable epilepsy. The mechanisms underlying its anticonvulsant action remain poorly understood....
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A Study on the Age-Dependent Ketosis Induced by the Ketogenic Diet

Kim DW, Moon JS, Jang HO, Park HD, Kim JM, Jung KY, Chae SA, Park HJ

  • KMID: 2181952
  • J Korean Epilepsy Soc.
  • 2003 Dec;7(2):108-111.
PURPOSE: Ketogenic diet (KD) remains a therapy in search of explanation although it is an established treatment for patients with intractable epilepsy. It has been clinically proven more efficacious at...
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A Study on the Age-Dependent Antiepileptic Effects of the Ketogenic Diet in the Pentylenetetrazole-Seizure Animal Model

Kim DW, Chae SA, Park HJ

  • KMID: 2007340
  • J Korean Child Neurol Soc.
  • 2002 May;10(1):29-34.
PURPOSE: The ketogenic diet(KD) has been felt to be clinically more efficacious at younger ages, presumably because of the enhanced ability of the immature brain to extract and utilize ketone...
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Predictive Comparisons of Procalcitonin (PCT) Level, Arterial Ketone Body Ratio (AKBR), APACHE III Score and Multiple Organ Dysfunction Score (MODS) in Systemic Inflammatory Response Syndrome (SIRS)

Lee YJ, Park CH, Yun JW, Lee YS

Procalcitonin (PCT) is a newly introduced marker of systemic inflammation and bacterial infection. A marked increase in circulating PCT level in critically ill patients has been related with the severity...
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