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An Association Study of the Signal Transducer and Activator of Transcription 6 Gene With Periodic Psychosis

Kawashige , Kanazawa T, Tsutsumi A, Kikuyama H, Uenishi H, Koh J, Yoneda H

  • KMID: 2315784
  • Psychiatry Investig.
  • 2008 Mar;5(1):41-44.
OBJECTIVE: Recent molecular and genetic investigations have suggested that the current nosology for major psychiatric disorders, based on the "two-entities-principal" is not accurate with respect to clinical observations; patient groups...
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Association between Medication Adherence and Duration of Outpatient Treatment in Patients with Schizophrenia

Tarutani S, Kikuyama H, Ohta M, Kanazawa T, Okamura T, Yoneda H

OBJECTIVE: Medication adherence is important in the treatment of schizophrenia, and critical periods during treatment may be associated with relapse. However, the relationship between adherence and duration of outpatient treatment...
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Comparative Analysis of the WISC between Two ADHD Subgroups

Kubo Y, Kanazawa T, Kawabata Y, Tanaka K, Okayama T, Fujta M, Tsutsumi A, Yokota S, Yoneda H

OBJECTIVE: The prevalence of attention deficit/hyperactivity disorder (ADHD) in school-age children is 7.2%, and ADHD is divided into clinical subtypes. METHODS: The current study explored whether specific cognitive profiles as assessed...
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Clozapine Is Better Tolerated in Younger Patients: Risk Factors for Discontinuation from a Nationwide Database in Japan

Toyoda K, Hata T, Yamauchi S, Kinoshita S, Nishihara M, Uchiyama K, Inada K, Kanazawa T

Objective The effectiveness of clozapine is clearly superior to other antipsychotics in the treatment of refractory schizophrenia. Clozapine leads to various side effects, and therefore many patients are forced to...
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Effect of suprascapular nerve injury on muscle and regenerated enthesis in a rat rotator cuff tear model

Eshima K, Ohzono H, Gotoh M, Shimokobe H, Tanaka K, Nakamura H, Kanazawa T, Okawa T, Shiba N

Background: Massive rotator cuff tears (RCTs) are complicated by muscle atrophy, fibrosis, and intramuscular fatty degeneration, which are associated with postoperative tendon-to-bone healing failure and poor clinical outcomes. We evaluated...
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The Mechanism of Anti-Epileptogenesis by Levetiracetam Treatment is Similar to the Spontaneous Recovery of Idiopathic Generalized Epilepsy during Adolescence

Kikuyama H, Hanaoka T, Kanazawa T, Yoshida Y, Mizuno T, Toyoda H, Yoneda H

OBJECTIVE: The anti-epileptogenic drug levetiracetam has anticonvulsant and anti-epileptogenesis effects. Synergy between cell death and inflammation can lead to increased levels of apoptosis inhibitory factors and brain-derived neurotrophic factor, aberrant...
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fNIRS Assessment during an Emotional Stroop Task among Patients with Depression: Replication and Extension

Nishizawa , Kanazawa T, Kawabata Y, Matsubara , Maruyama S, Kawano M, Kinoshita , Koh J, Matsuo K, Yoneda H

OBJECTIVE: Accumulated evidence collected via functional near-infrared spectroscopy (fNIRS) has been reported with regard to mental disorders. A previous finding revealed that emotional words evoke left frontal cortex activity in...
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Increases in iPS Transcription Factor (Oct4, Sox2, c-Myc, and Klf4) Gene Expression after Modified Electroconvulsive Therapy

Nishiguchi M, Kikuyama H, Kanazawa T, Tsutsumi A, Kaneko T, Uenishi H, Kawabata Y, Kawashige , Koh J, Yoneda H

OBJECTIVE: Electroconvulsive therapy (ECT) is a reasonable option for intractable depression or schizophrenia, but a mechanism of action has not been established. One credible hypothesis is related to neural plasticity....
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Genetic Polymorphisms in Dopamine- and Serotonin-Related Genes and Treatment Responses to Risperidone and Perospirone

Tsutsumi A, Kanazawa T, Kikuyama H, Okugawa G, Uenishi H, Miyamoto T, Matsumoto , Koh J, Shinosaki , Kishimoto , Yoneda H, Kinoshita

  • KMID: 2315841
  • Psychiatry Investig.
  • 2009 Sep;6(3):222-225.
We investigated the possible association between genetic polymorphisms in the dopamine receptor and serotonin transporter genes and the responses of schizophrenic patients treated with either risperidone or perospirone. The subjects...
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