- The Influence of Biomarker Mutations and Systemic Treatment on Cerebral Metastases from NSCLC Treated with Radiosurgery
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Lee MH, Kong DS, Seol HJ, Nam DH, Lee JI
- KMID: 2365583
- J Korean Neurosurg Soc.
- 2017 Jan;60(1):21-29.
- doi: 10.3340/jkns.2016.0404.005
OBJECTIVE: The purpose of this study was to analyze outcomes and identify prognostic factors in patients with cerebral metastases from non-small cell lung cancer (NSCLC) treated with gamma knife radiosurgery... -
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- High-fat-diet-modulated Gut Microbiota Promotes Intestinal Carcinogenesis
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Ali I, Koh YS
- KMID: 2168725
- J Bacteriol Virol.
- 2015 Dec;45(4):394-396.
- doi: 10.4167/jbv.2015.45.4.394
Gut microbiota play a critical role in the development of intestinal cancer. Dietary changes cause dysbiosis of gut microbiota that mediates production of dietary factors triggering intestinal cancer. Genetic and... -
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- A case of therapy-related acute myeloid leukemia with inv(16)(p13.1q22) after single low-dose iodine-131 treatment for thyroid cancer
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Jeong JH, Ahn JY, Park SH, Park MJ, Kim KH, Hong JS
- KMID: 2251958
- Korean J Hematol.
- 2012 Sep;47(3):225-228.
- doi: 10.5045/kjh.2012.47.3.225
Radioiodine is regularly used in the treatment of thyroid cancer to eliminate residual malignant tissue after thyroidectomy and to treat metastasis. Because of the low dose of radioiodine used to... -
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- The Clinical Significance of Transforming Growth Factor (TGF) beta1, TGF beta Receptor beta II, p53 Protein and K-ras Point Mutation in Pancreatic Cancer
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Kim KS, Chae YS, Kim JT
- KMID: 2211144
- J Korean Surg Soc.
- 2008 Apr;74(4):274-281.
PURPOSE: Many cancers, including pancreatic cancer, harbor defects in TGF beta signaling and are resistant to TGF beta mediated growth inhibition. In addition, the expression of the p53 gene and... -
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- K-ras Gene Mutation in Non-Small Cell Lung Cancer
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Yoon HJ, Ju JY, Cho GJ, Kim EJ, Park KH, Kim KS, Ko YC, Lim SC, Kim YC, Park KO, Park JT
- KMID: 2200234
- J Lung Cancer.
- 2002 Dec;1(1):55-59.
PURPOSE: Point mutation of the K-ras gene causes irreversible binding of GTP to the P21-ras protein, which induces nuclear transcription factors and enhances cellular proliferation. Point mutation of the K-ras... -
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- K-ras Mutation, p53 Overexpression, and p16 Deletion in Intraductal Papillary Mucinous Tumors of the Pancreas
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Chang HS, Kim MH, Myung SJ, Lee SK, Lee SS, Seo DW, Kim KR, Min YI, Gong GY, Yu ES
- KMID: 1647068
- Korean J Gastroenterol.
- 2002 Sep;40(3):197-203.
BACKGROUND/AIMS: Intraductal papillary mucinous tumors (IPMTs) of the pancreas contain a wide spectrum of histopathologic abnormalities ranging from hyperplasia to adenocarcinoma. Unlike ductal adenocarcinomas of the pancreas, the genetic alterations... -
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- p53 and K-ras Expression in Interstitial Lung Disease
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Oh IJ, Kim YI, Kim KS, Yoo YK, Kim SO, Lee EW, Lim SC, Kim YC, Park KO, Park CS
- KMID: 2160007
- Tuberc Respir Dis.
- 2001 Sep;51(3):201-210.
- doi: 10.4046/trd.2001.51.3.201
BACKGROUND: Approximately 10-13% of patients with interstitial lung disease(ILD) die of lung cancer, and patients with ILD have been reported to have a 7 fold higher incidence of lung cancer... -
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- The Relationship between Microvessel Count and the Expression of Vascular Endothelial Growth Factor, p53, and K-ras in Non-Small Cell Lung Cancer
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Kang YH, Kim KS, Yu YK, Lim SC, Kim YC, Park KO
- KMID: 648299
- J Korean Med Sci.
- 2001 Aug;16(4):417-423.
- doi: 10.3346/jkms.2001.16.4.417
Using immunohistochemical staining, we studied the relationship between the microvessel count (MC) and the expression of K-ras, mutant p53 protein, and vascular endothelial growth factor (VEGF) in 61 surgically resected... -
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- ras Gene Mutations in Malignant Fibrous Histiocytoma
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Yoo J, Lee AW, Kang SJ, Kim BK
- KMID: 2275609
- Korean J Pathol.
- 2001 Jun;35(3):232-237.
BACKGROUND: ras gene mutations have been described in various human malignancies, suggesting that their activation may play a role in oncogenesis. However, there are few reports concerning ras gene alterations... -
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- K-ras Mutation in Ampulla of Vater Cancer
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Park SJ, Kim SW, Kim WH, Jang JY, Park YH
- KMID: 1815316
- J Korean Cancer Assoc.
- 2000 Oct;32(5):981-988.
PURPOSE: The aims of this study was to elucidate the role of the K-ras mutation (codon 12) in the carcinogenesis of ampulla of Vater cancer. MATERIALS AND METHODS: 31 cases... -
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- Histopathologic Findings, and p53 and K-ras Mutational Analysis in Biopsy Specimens Using Fluorescence Bronchoscopy
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Kim YS, Park SH, Jung MH, Choi EC, Park IY, Kim HK, Kim I
- KMID: 2011739
- Korean J Pathol.
- 2000 Aug;34(8):550-558.
A fluorescence bronchoscope system has been developed for detecting early lung cancer including dysplasia and carcinoma in situ. To determine the histologic findings and genetic alterations of the lung tissues,... -
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- Clinical Significance of p53 Protein Expression and K-ras Point Mutation in Pancreatic Cancer and Chronic Pancreatitis
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Roe IH, Nam SW, Lee MI, Hwang YJ, Lee BS, Park HJ, Kim BH, Kim JT, Cho CH
- KMID: 2240333
- Korean J Gastroenterol.
- 2000 May;35(5):629-637.
BACKGROUND/AIMS: The aims of this study were to evaluate the expression rate of p53 protein and K-ras mutation in pancreatic carcinogenesis, and to determine their clinical significance. METHODS: Specimens were obtained from 26... -
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- Significance of K-ras mutation, K-ras expression and p53 expression in pancreatic cancer
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Kim YC, Choi KH, Kim HG, Lee ES, Son GS
- KMID: 2244393
- Korean J Hepatobiliary Pancreat Surg.
- 2000 Feb;4(1):111-121.
BACKGROUND: Though K-ras mutation and aberrant p53 have been considered the event of the oncogenesis of pancreatic adenocarcinoma, it is controversial that these have been attributed to difference of survival... -
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- Significance of K-ras Mutation and p53 Protein Expression in Pancreatic Adenocarcinoma
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Kim YC, Choi KH
- KMID: 2145297
- J Korean Surg Soc.
- 2000 Feb;58(2):271-279.
BACKGROUND: Activation of the K-ras oncogene by specific point mutations at codon 12 occurs at a remarkably high frequency in pancreatic adenocarcinomas. Also, inactivation of the p53 suppressor gene function... -
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- Brush Cytology and K-ras Mutation Analysis of the Bile for the Diagnosis of Malignant and Benign Biliary Stricture Diseases
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Park SH, Roe IH, Lee MI, Kim SB, Huh JH, Tak WT, Yu K, Kim JT, Lee HS, Lee JH
- KMID: 1571062
- Korean J Gastroenterol.
- 2000 Feb;35(2):219-225.
BACKGROUND/AIMS: In cases that clear distinction between benign and malignant stricture is difficult on the basis of endoscopic retrograde cholangiopancreatography (ERCP) findings, cytologic confirmation is usually needed. Recently, K-ras mutation... -
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- Diagnostic Utility of K-ras Mutation in the Sample of Percutaneous Needle Aspiraton of Pancreatic Cancer and Chronic Pancreatitis
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Lee WJ, Jang YH, Ryu JK, Kim YT, Yoon YB, Kim CY, Han JK
- KMID: 2304631
- Korean J Gastroenterol.
- 2000 Jan;35(1):93-102.
BACKGROUND/AIMS: K-ras gene mutation is present in 80-90% of human pancreatic cancer and thus, could be used as a new diagnostic tool. The purpose of this study was to assess the utility... -
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- Detection of Point Mutations in the K-ras Oncogene in Pancreatic Juice for Differential Diagnosis between Pancreatic Carcinoma and Chronic Pancreatitis
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Oh HT, Roe IH, Lee MI, Hwang EC, Lee MS, Kim SB, Song IH, Yang MR, Lee HS, Lee JH
- KMID: 1772572
- Korean J Gastroenterol.
- 1999 Dec;34(6):806-814.
BACKGROUND/AIMS: Mutations in K-ras oncogene at codon 12 are detected in 80-90% of pancreatic carcinomas, which is suggested to be a critical event in the early stage of oncogenesis. The... -
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- K-ras and p53 gene mutation in endometrial hyperplasia and adenocarcinoma
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Kim HO, Lee JH, Lee IW, Han SA, Park MJ, Cho HD, Kim IS, Kim CH
- KMID: 2261537
- Korean J Obstet Gynecol.
- 1999 Oct;42(10):2192-2198.
Endometrial adenocarcinoma is the third common malignancy of female genital tract and categorized as estrogen-dependent tumor (type I) or not (type II). Type II endometrial adenocarcinoma more frequently occurs... -
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- Telomerase Activity and K-ras Gene Mutation in Pancreatic Juice for Diagnosis of Pancreatic Cancer
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Jung HK, Son HY, Lee HC, Kim DY, Yi SY, Moon IH, Myung SJ, Seo DW, Lee SK, Min YI, Kim MH
- KMID: 2038341
- Korean J Gastroenterol.
- 1999 Aug;34(2):245-254.
BACKGROUND/AIMS: The reactivation of telomerase may be concomitant with the cell immortality and mutations of the K-ras gene are common genetic alteration found in pancreatic carcinomas. The purpose of this... -
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- Effects of the Mutation of the p53 Tumor Suppressor Gene and the K-ras Gene on Clinical Manifestation in Non-small Cell Lung Cancer
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Lee HL, Ryu JS, Kim JH, Kim SK, Lee WY, Lee YH
- KMID: 2306340
- Korean J Med.
- 1998 Nov;55(5):854-867.
OBJECTIVE: A multistep process of gene alterations is required for tumor formation. p53 gene mutation is the most frequent and K-ras gene mutation places second in the gene abnormalities of... -
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