- Another leap for EMM into a new era
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Jue DM
- KMID: 2154220
- Exp Mol Med.
- 2013 Jan;45(1):e1.
No abstract available. -
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- Murine pro-tumor necrosis factor expressed in Saccharomyces cerevisiae HF7c localizes to membrane/particulate
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Jeong JY, Jue DM
- KMID: 1109303
- Exp Mol Med.
- 2000 Jun;32(2):61-66.
Tumor necrosis factor (TNF) is a cytokine that is produced by immune cells in response to bacterial and viral stimuli and plays important roles in various inflammatory diseases. TNF... -
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- Gold compound auranofin inhibits I kappaB kinase (IKK) by modifying Cys-179 of IKK beta subunit
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Jeon KI, Byun MS, Jue DM
- KMID: 1097252
- Exp Mol Med.
- 2003 Apr;35(2):61-66.
Antirheumatic gold compounds have been shown to inhibit NF-kB activation by blocking IkB kinase (IKK) activity. To examine the possible inhibitory mechanism of gold compounds, we expressed wild type and... -
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- Cysteine-179 of I kappa B kinase beta plays a critical role in enzyme activation by promoting phosphorylation of activation loop serines
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Byun MS, Choi J, Jue DM
- KMID: 1098089
- Exp Mol Med.
- 2006 Oct;38(5):546-552.
I kappa B kinase beta (IKK beta) subunit of IKK complex is essential for the activation of NF-kappa B in response to various proinflammatory signals. Cys-179 in the activation loop... -
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- Nuclear factor kappaB (NF-kappaB) pathway as a therapeutic target in rheumatoid arthritis
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Jue DM, Jeon KI, Jeong JY
- KMID: 646299
- J Korean Med Sci.
- 1999 Jun;14(3):231-238.
- doi: 10.3346/jkms.1999.14.3.231
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by persistent joint swelling and progressive destruction of cartilage and bone. Current RA treatments are largely empirical in origin and their... -
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- Transient exposure to hydrogen peroxide inhibits the ubiquitination of phosphorylated IkappaBalpha in TNFalpha-stimulated HEK293 cells
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Lee Y, Choi J, Ha KH, Jue DM
- KMID: 1387362
- Exp Mol Med.
- 2012 Aug;44(8):513-520.
During ischemia-reperfusion injury, brief pre-exposure to oxidative stress renders organs resistant to subsequent severe damage. NF-kappaB is a transcription factor that is involved in reperfusion-induced inflammatory and immune responses. The... -
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- Dual effect of oxidative stress on NF-kappaB activation in HeLa cells
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Byun MS, Jeon KI, Choi JW, Shim JY, Jue DM
- KMID: 755204
- Exp Mol Med.
- 2002 Nov;34(5):332-339.
Reactive oxygen species (ROS) has been implicated as an inducer of NF-kappaB activity in numbers of cell types where exposure of cells to ROS such as H2O2 leads to NF-kappaB... -
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- Measurement of Serum Fas Ligand (FasL), FasL-Fas Complex and FasL-IgG Complex in Patients with Rheumatic Diseases
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Min JK, Min SY, Cho MR, Jeong JY, Jue DM, Min DJ, Cho CS, Kim HY
- KMID: 1817743
- J Korean Rheum Assoc.
- 2000 Dec;7(4):390-401.
OBJECTIVE: To quantify the soluble Fas ligand (sFasL) and to measure FasL-Fas complex and FasL-IgG complex in the sera of patients with various rheumatic diseases: systemic lupus erythematosus (SLE),... -
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- Regulation of Interleukin-17 Production in Patients with Rheumatoid Arthritis by Phosphoinositide 3-kinase (PI3K)/ Akt and Nuclear Factor KappaB (NF-kappaB) Dependent Signal Transduction Pathway
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Kim KW, Cho ML, Lee SH, Min SY, Park MK, Park SH, Jue DM, Kim HY
- KMID: 2054236
- Immune Netw.
- 2003 Dec;3(4):310-319.
- doi: 10.4110/in.2003.3.4.310
Inflammatory mediators has been recognized as an important role in the pathogenesis of rheumatoid arthritis (RA). IL-17 is increasingly recognized as an important regulator of immune and inflammatory responses, including... -
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