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Early Administration of Nelonemdaz May Improve the Stroke Outcomes in Patients With Acute Stroke

Lee JS, Lee JS, Ahn SH, Kang HG, Song TJ, Shin DI, Bae HJ, Kim CH, Heo SH, Cha JK, Lee YB, Kim EG, Park MS, Park HK, Kim J, Yu S, Mo H, Sohn SI, Kwon JH, Kim JG, Kim YS, Choi JC, Hwang YH, Jung KH, Kim SK, Seo WK, Seo JH, Yoo J, Chang JY, Park M, Yum KS, An CS, Gwag BJ, Choi DW, Hong JM, Kwon SU, the SONIC and RODIN Investigators

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Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation

Koga M, Branca M, Strbian D, Yoshimoto T, Tanaka K, Yoshimura S, Yakushiji Y, Fujimoto S, Vedamurthy A, Krishnan M, Tiainen M, Vehoff J, Sibolt G, Matsuzono K, Kulyk C, Räty S, Slade P, Salerno A, Hemelsoet D, Horvath T, Kunieda T, Nakajima M, Akiyama H, Iguchi Y, Inoue M, Ihara M, Toyoda K, Seiffge D, Goeldlin M, Dawson J, Fischer U

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Combining Computed Tomography Perfusion and Baseline National Institutes of Health Stroke Scale to Assess the Clinical Penumbra in Ischemic Stroke

Pensato U, Stebner A, Bosshart S, Shah R, Rohr A, Hanel R, Kelly ME, Bharatha A, Hill MD, Goyal M, Demchuk AM, Ospel JM

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The Association of Lipoprotein(a) and Stroke Recurrence: A Systematic Review and Meta-Analysis

Palaiodimou L, Melanis K, Stefanou MI, Theodorou A, Giannopoulos S, Lambadiari V, Sousa DAd, Sacco S, Katan M, Siasos G, Tsivgoulis G

Background and Purpose Lipoprotein(a) [Lp(a)] is a lipoprotein structurally similar to low-density lipoprotein and is considered a genetically determined risk factor for cardiovascular disease. Although Lp(a) has been linked to...
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Anticoagulation Failure in Stroke: Causes, Risk Factors, and Treatment

Choi Y, Kim JS

Anticoagulation is crucial to reducing the risk of cardioembolic strokes, particularly in vulnerable populations such as patients with atrial fibrillation, artificial heart valves, or left ventricular thrombus. Though successful, anticoagulation...
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Low-Density Lipoprotein Cholesterol Level, the Lower the Better? Analysis of Korean Patients in the Treat Stroke to Target Trial

Kwon H, Ryu JC, Cha JK, Sung SM, Song TJ, Lee KB, Kim EG, Kim YW, Heo JH, Park MS, Kang K, Lee BC, Hong KS, Bang OY, Kim J, Kim JS

Background and Purpose The Treat Stroke to Target (TST) was a randomized clinical trial involving French and Korean patients demonstrating that a lower low-density lipoprotein cholesterol (LDL-C,
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Premature Ischemic Stroke in Sjögren’s Disease

Beider S, Zehrfeld N, Tapken FM, Engelke F, Seeliger T, Skripuletz T, Witte T, Ernst D

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Robotic Stroke Thrombectomy: A Feasibility and Efficacy Study in Flow Models

Williams CJ, Rice H, Yan B, Villiers Ld, Nascimento VCd, Mitchell PJ, Manning NW, Churilov L, Parsons MW, Davis SM, Donnan GA

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Optimal Low-Density Lipoprotein Cholesterol Level: Time to Reconsider Stroke Subtypes

Kim JS

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Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis

Polymeris AA, Koga M, Strbian D, Vedamurthy A, Krishnan M, Branca M, Horvath T, Goeldlin M, Shim G, Gumbinger C, Zhang L, Kristoffersen ES, Desfontaines P, Vanacker P, Alonso A, Poli S, Nunes AP, Caracciolo NG, Kneihsl M, Kahles T, Giudici D, Räty S, Tiainen M, Dawson J, Fischer U, the ELAN Investigators

Background and Purpose Antiplatelets are often used before direct oral anticoagulant (DOACs) initiation after an acute ischemic stroke related to atrial fibrillation (AF), but the evidence is weak. Here, we...
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Carotid Web: An Update Focusing on Its Relationship With Fibromuscular Dysplasia and Therapeutic Strategy

Zedde M, Stoenoiu MS, Persu A, Pascarella R

Carotid web was described more than 50 years ago as an atypical fibromuscular dysplasia (FMD) subtype with highly supporting pathological evidence as intimal FMD. In the following decades, the transition...
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Tenecteplase Beyond 4.5 Hours in Acute Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials

Aladawi M, Abuawwad MT, Taha MJJ, Kozaa YA, Alrubasy WA, Hamad A, Alhnidi FA, Elfil M, Najdawi Z, Peng X, Hataway F, Bakradze E, Lyerly MJ

Background and Purpose Acute ischemic stroke (AIS) is a leading cause of disability worldwide. While intravenous thrombolysis is recommended within 4.5 hours of last known well (LKW) time, many patients...
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Switch to Rosuvastatin Plus Ezetimibe From Statin Monotherapy to Achieve Target LDL-Cholesterol Goal: A Multi-Center, Open-Label, Single-Arm Trial

Park HK, Park JH, Park HK, Kang K, Jung KH, Kim BJ, Jung JM, Kim YS, Lee YS, Nam HS, Yu Y, Lee J, Hong KS

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Longitudinal Measurement of Serum Neurofilament Light Chain in Patients With CADASIL

Lee JS, Kang JH, Kang CH, Kim JG, Seo SW, Park YH, Yun J, Yun SY, Choi JC

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Revisiting the Etiology of Cocaine-Related Ischemic Strokes: An Observational Cohort

Kozel OA, Kothari SA, Desai H, Behera A, Morsi RZ, Baskaran AB, Sehgal N, Prabhakaran S, Kass-Hout T, Siegler JE, Mendelson SJ

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Prolonged Benefit of Endovascular Treatment for Acute Basilar Artery Occlusion With Large Ischemic Infarcts: One-Year Outcomes From the PERSIST Registry

Zhang P, Xu Y, Hu M, Zhong J, Liu X, Sun W

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Aldehyde Dehydrogenase 2 Gene Mutation May Reduce the Risk of Rupture of Intracranial Aneurysm in Chinese Han Population

Chen X, Gui S, Wei D, Deng D, Tang Y, Lv J, You W, Jiang J, Lin J, Ge H, Liu P, Jiang Y, Ma L, Wang Y, Lv M, Li Y

Background and Purpose Ruptured intracranial aneurysms (RIA) are associated with a mortality rate of up to 40% in the Chinese population, highlighting the critical need for targeted treatment interventions for...
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Residual Inflammatory Risk and Intracranial Atherosclerosis Plaque Vulnerability: Insights From High-Resolution Magnetic Resonance Imaging

Yu Y, Cui R, He X, Shi X, Hou Z, Pan Y, Li M, Yang J, Miao Z, Wang Y, Wang R, Lou X, Yan L, Ma N

Background and Purpose This study aimed to investigate the association between residual inflammatory risk (RIR) and vulnerable plaques using high-resolution magnetic resonance imaging (HRMRI) in symptomatic intracranial atherosclerotic stenosis (ICAS). Methods...
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