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The Transformative Impact of New Anti-Obesity Medications: A Paradigm Shift in Medical Practice?

Sharma AM

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DNA Methylation in the Hypothalamic Feeding Center and Obesity

Yoshikawa C, Ariyani W, Kohno D

Obesity rates have been increasing worldwide for decades, mainly due to environmental factors, such as diet, nutrition, and exercise. However, the molecular mechanisms through which environmental factors induce obesity remain...
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Smoking Disturbs the Beneficial Effects of Continuous Positive Airway Pressure Therapy on Leptin Level in Obstructive Sleep Apnea

Suzgun MA, Kabeloglu V, Senel GB, Karadeniz D

Background: This study aimed to determine how smoking alters the effect of positive airway pressure (PAP) therapy on metabolic syndrome in obstructive sleep apnea (OSA). Methods: In this clinical trial, morphometric...
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Fat Biology in Triple-Negative Breast Cancer: Immune Regulation, Fibrosis, and Senescence

Lee CM, Fang S

Obesity, now officially recognized as a disease requiring intervention, has emerged as a significant health concern due to its strong association with elevated susceptibility to diverse diseases and various types...
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Mitochondrial Quality Control: Its Role in Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

Shin S, Kim J, Lee JY, Kim J, Oh CM

Metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, is characterized by hepatic steatosis and metabolic dysfunction and is often associated with obesity and insulin resistance....
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Sugar-Rich Food Intake Is Negatively Associated with Plasma Pentraxin 3 Levels

Zempo-Miyaki A, Kumagai H, Tanahashi K, Zempo H, Otsuki T, Maeda S

Background: Levels of pentraxin 3 (PTX3), an anti-inflammatory cardioprotective protein, increase after weight loss in obese men and aerobic exercise in non-obese adults. However, the effect of nutritional characteristics on...
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An Overview of the Mechanism behind Excessive Volume of Pericardial Fat in Heart Failure

Karna S, Kang KW

Heart failure (HF) is a clinical syndrome characterized by myocardial dysfunction leading to inefficient blood filling or ejection. Regardless of the etiology, various mechanisms, including adipokine hypersecretion, proinflammatory cytokines, stem...
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Effect of Short Bouts of Vigorous Stair Climbing on Cardiorespiratory Fitness in Women with Overweight and Obesity: A Pilot Feasibility Study

Yun JE, Wen X, Han M, Cho S, Kuk JL, Lee S

Background: We examined the effect of 4 weeks of a brief vigorous stair climbing exercise on cardiorespiratory fitness (CRF) and body composition in women with overweight or obesity. Methods: Twenty-six participants...
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