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Influence of Intranasal Drugs on Human Nasal Mucociliary Clearance and Ciliary Beat Frequency

Jiao J, Zhang L

The nasal mucociliary clearance system, which comprises epithelial cilia and mucus from goblet cells, is an important intrinsic defense mechanism of the upper respiratory tract. Intranasal drugs and additives can...
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Dysregulated Dermal Mesenchymal Stem Cell Proliferation and Differentiation Interfered by Glucose Metabolism in Psoriasis

Zhao X, Xing J, Li J, Hou R, Niu X, Liu R, Jiao J, Yang X, Li J, Liang J, Zhou L, Wang Q, Chang W, Yin G, Li X, Zhang K

Background and Objectives: Psoriasis is a chronic inflammatory skin disease, which the mechanisms behind its initiation and development are related to many factors. DMSCs (dermal mesenchymal stem cells) represent an...
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Depletion of S100A4⁺ stromal cells does not prevent HCC development but reduces the stem cell-like phenotype of the tumors

Jiao J, González , Stevenson , Gagea M, Sugimoto H, Kalluri R, Beretta L

There is a pressing need for the development of novel approaches to treat and prevent hepatocellular carcinoma (HCC). The S100 calcium-binding protein S100A4 is associated with poor prognosis and metastasis...
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In Vivo Assessment of Neurodegeneration in Type C Niemann-Pick Disease by IDEAL-IQ

Guo RM, Li QL, Luo ZX, Tang W, Jiao J, Wang J, Kang Z, Chen SQ, Zhang Y

OBJECTIVE: To noninvasively assess the neurodegenerative changes in the brain of patients with Niemann-Pick type C (NPC) disease by measuring the lesion tissue with the iterative decomposition of water and...
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TMEM16A-Mediated Mucin Secretion in IL-13-Induced Nasal Epithelial Cells From Chronic Rhinosinusitis Patients

Zhang Y, Wang X, Wang H, Jiao J, Li Y, Fan E, Zhang L, Bachert C

PURPOSE: Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), a calcium-activated Cl- channel (CaCC), can...
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