- Rapidly Growing and Aggressive Cutaneous Squamous Cell Carcinomas in a Patient Treated with Ruxolitinib
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March-Rodriguez A, Bellosillo B, Ãlvarez-Larrán A, Besses C, Pujol RM, Toll A
- KMID: 2439067
- Ann Dermatol.
- 2019 Apr;31(2):204-208.
- doi: 10.5021/ad.2019.31.2.204
Ruxolitinib is a Janus kinase (JAK)1 and JAK2 inhibitor approved for the treatment of myelofibrosis and for polycythemia patients who are resistant or intolerant to hydroxyurea. We report a 72... -
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- Immunohistochemistry of Janus Kinase 1 (JAK1) Expression in Vitiligo
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Abdou AG, Maraee A, Yassien H, Sarhan M
- KMID: 2427518
- J Pathol Transl Med.
- 2018 Nov;52(6):363-368.
- doi: 10.4132/jptm.2018.09.18
BACKGROUND: Vitiligo is a chronic autoimmune disease in which the destruction of melanocytes causes white spots on the affected skin. Janus kinase (JAK) is a family of intracellular, non-receptor tyrosine... -
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- Afatinib Reduces STAT6 Signaling of Host ARPE-19 Cells Infected with Toxoplasma gondii
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Yang Z, Ahn HJ, Park YH, Nam HW
- KMID: 2374014
- Korean J Parasitol.
- 2016 Feb;54(1):31-38.
- doi: 10.3347/kjp.2016.54.1.31
Specific gene expressions of host cells by spontaneous STAT6 phosphorylation are major strategy for the survival of intracellular Toxoplasma gondii against parasiticidal events through STAT1 phosphorylation by infection provoked IFN-γ.... -
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- Jak1/Stat3 Is an Upstream Signaling of NF-kappaB Activation in Helicobacter pylori-Induced IL-8 Production in Gastric Epithelial AGS Cells
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Cha B, Lim JW, Kim H
- KMID: 2450365
- Yonsei Med J.
- 2015 May;56(3):862-866.
- doi: 10.3349/ymj.2015.56.3.862
Helicobacter pylori (H. pylori) induces the activation of nuclear factor-kB (NF-kappaB) and cytokine expression in gastric epithelial cells. The Janus kinase/signal transducers and activators of transcription (Jak/Stat) cascade is the... -
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- alpha-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-kappaB in H. pylori-Infected Gastric Epithelial AGS Cells
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Choi JH, Cho SO, Kim H
- KMID: 2466379
- Yonsei Med J.
- 2016 Jan;57(1):260-264.
- doi: 10.3349/ymj.2016.57.1.260
The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in... -
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