- microRNA-146a Promotes Growth of Acute Leukemia Cells by Downregulating Ciliary Neurotrophic Factor Receptor and Activating JAK2/STAT3 Signaling
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Wang L, Zhang H, Lei D
- KMID: 2459145
- Yonsei Med J.
- 2019 Oct;60(10):924-934.
- doi: 10.3349/ymj.2019.60.10.924
PURPOSE: Acute leukemia (AL) is classified as acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). This study aimed to investigate the effect of miR-146a on childhood AL and its... -
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- Cancer-Associated Fibroblasts Promote the Chemo-resistance in Gastric Cancer through Secreting IL-11 Targeting JAK/STAT3/Bcl2 Pathway
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Ma J, Song X, Xu X, Mou Y
- KMID: 2437613
- Cancer Res Treat.
- 2019 Jan;51(1):194-210.
- doi: 10.4143/crt.2018.031
PURPOSE: Our aim was to detect the potential role of interleukin 11 (IL-11) in the development of chemo-resistance in gastric cancer and to reveal the mechanism involved in the process. MATERIALS... -
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- JAK/STAT Pathway Modulates on Porphyromonas gingivalis Lipopolysaccharide- and Nicotine-Induced Inflammation in Osteoblasts
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Han YK, Lee IS, Lee SI
- KMID: 2371028
- J Dent Hyg Sci.
- 2017 Feb;17(1):81-86.
- doi: 10.17135/jdhs.2017.17.1.81
Bacterial infection and smoking are an important risk factors involved in the development and progression of periodontitis. However, the signaling mechanism underlying the host immune response is not fully understood... -
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- alpha-Lipoic Acid Inhibits Expression of IL-8 by Suppressing Activation of MAPK, Jak/Stat, and NF-kappaB in H. pylori-Infected Gastric Epithelial AGS Cells
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Choi JH, Cho SO, Kim H
- KMID: 2466379
- Yonsei Med J.
- 2016 Jan;57(1):260-264.
- doi: 10.3349/ymj.2016.57.1.260
The epithelial cytokine response, associated with reactive oxygen species (ROS), is important in Helicobacter pylori (H. pylori)-induced inflammation. H. pylori induces the production of ROS, which may be involved in... -
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- Anti-inflammatory activity of compounds isolated from Astragalus sinicus L. in cytokine-induced keratinocytes and skin
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Kim BH, Oh I, Kim JH, Jeon JE, Jeon B, Shin J, Kim TY
- KMID: 2155352
- Exp Mol Med.
- 2014 Mar;46(3):e87.
- doi: 10.1038/emm.2013.157
Inflammation is a part of the complex biological responses of a tissue to injury that protect the organ by removing injurious stimuli and initiating the healing process, and is considered... -
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- Role of Janus Kinase/Signal Transducers and Activators of Transcription in the Pathogenesis of Pancreatitis and Pancreatic Cancer
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Yu JH, Kim H
- KMID: 2167409
- Gut Liver.
- 2012 Oct;6(4):417-422.
In the pathogenesis of pancreatitis, oxidative stress is involved in the activation of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway and cytokine expression. High serum levels of... -
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