- Ionizing radiation induces blockade of c-Jun N-terminal kinasedependent cell death pathway in amanner correlated with p21Cip/WAF1 induction in primary cultured normal human fibroblasts
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Cho ES, Lee SB, Bae IH, Lee YS, Lee SJ, Um HD
- KMID: 1093463
- Exp Mol Med.
- 2005 Aug;37(4):282-289.
During radiotherapy of cancer, neighboring normal cells may receive sub-lethal doses of radiation. To investigate whether such low levels of radiation modulate normal cell responses to death stimuli, primary cultured... -
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- JNK inhibitor SP600125 promotes the formation of polymerized tubulin, leading to G2/M phase arrest, endoreduplication, and delayed apoptosis
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Moon DO, Kim MO, Kang CH, Lee JD, Choi YH, Kim GY
- KMID: 756210
- Exp Mol Med.
- 2009 Sep;41(9):665-677.
- doi: 10.3858/emm.2009.41.9.073
The JNK inhibitor SP600125 strongly inhibits cell proliferation in many human cancer cells by blocking cell-cycle progression and inducing apoptosis. Despite extensive study, the mechanism by which SP600125 inhibits mitosis-related... -
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