- Insight into Microenvironment Remodeling in Pancreatic Endocrine Tissue Engineering: Biological and Biomaterial Approaches
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Kaviani M, Azarpira N
- KMID: 2360796
- Tissue Eng Regen Med.
- 2016 Oct;13(5):475-484.
- doi: 10.1007/10.1007/s13770-016-0014-1
The treatment of diabetes mellitus, as a chronic and complicated disease, is a valuable purpose. Islet transplantation can provide metabolic stability and insulin independence in type 1 diabetes patients. Diet... -
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- Implications of Calcineurin/NFAT Inhibitors' Regulation of Dendritic Cells and Innate Immune Cells in Islet Xenotransplantation
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Kim YH, Lee WW, Park CG
- KMID: 2168737
- J Bacteriol Virol.
- 2016 Mar;46(1):1-12.
- doi: 10.4167/jbv.2016.46.1.1
Calcineurin inhibitors, such as cyclosporine and tacrolimus (FK506) are broadly used in organ transplantations as immune suppressants. As the calcineurin/NFAT signaling pathway has been identified as critical pathway in the... -
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- Management of Hypoglycemic Unawareness and the Current Status of Clinical Allogeneic Islet Transplantation
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Jin SM
- KMID: 2161124
- J Korean Diabetes.
- 2016 Mar;17(1):6-10.
- doi: 10.4093/jkd.2016.17.1.6
Problematic hypoglycemia is defined as a condition in which episodes of severe hypoglycemia are unpredictable and/or cannot be easily explained or prevented, typically associated with impaired awareness of hypoglycemia. The... -
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- Reversal of Hypoglycemia Unawareness with a Single-donor, Marginal Dose Allogeneic Islet Transplantation in Korea: A Case Report
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Yang HK, Ham DS, Park HS, Rhee M, You YH, Kim MJ, Kim JW, Lee SH, Hong TH, Choi BG, Cho JH, Yoon KH
- KMID: 2164488
- J Korean Med Sci.
- 2015 Jul;30(7):991-994.
- doi: 10.3346/jkms.2015.30.7.991
Pancreatic islet transplantation is a physiologically advantageous and minimally invasive procedure for the treatment of type 1 diabetes mellitus. Here, we describe the first reported case of successful allogeneic islet... -
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- Islet Encapsulation Using Chondrocyte
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Lee JI, Kim JY, Lee JG, Kim YS
- KMID: 1941312
- J Korean Soc Transplant.
- 2014 Dec;28(4):187-194.
- doi: 10.4285/jkstn.2014.28.4.187
Diabetes mellitus is one of the leading metabolic diseases that cause an increasing rate of mortality and morbidity. Recently, rather than the current drug treatment, pancreatic islet transplantation has been... -
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- Application of the Multiplex Cytokine Analysis to Monitor Xenogeneic Immune Responses to the Porcine Islet Graft in Non-Human Primate
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Kim YH, Kim JS, Yoon IH, Shin JS, Kim JM, Kim SJ, Park CG
- KMID: 1779412
- J Korean Med Sci.
- 2013 Dec;28(12):1729-1733.
- doi: 10.3346/jkms.2013.28.12.1729
Non-human primate studies must be conducted prior to the clinical trial of xenotransplantation. In order to develop clinically applicable immune-modulatory regimen through non-human primate studies, close monitoring of xenogeneic immune... -
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- Influence of Interferon-gamma Deficiency in Immune Tolerance Induced by Male Islet Transplantation
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Kim YH, Lim Y, Park CG
- KMID: 2150720
- Immune Netw.
- 2011 Dec;11(6):358-363.
- doi: 10.4110/in.2011.11.6.358
BACKGROUND: Traditionally, interferon-gamma (IFN-gamma) was regarded as a pro-inflammatory cytokine, however, recent reports suggested role of IFN-gamma in immune tolerance. In our previous report, we could induce tolerance to male... -
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- Progress in Pancreas Transplantation in Korea
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Cheon YK
- KMID: 1966877
- Korean J Med.
- 2011 Feb;80(2):164-166.
Pancreas transplantation is the most effective cure for type I diabetes because it is able to restore normal glucose homeostasis. Over the last 2 decades, improvements in immunosuppressive therapy have... -
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- Bilirubin protects grafts against nonspecific inflammation-induced injury in syngeneic intraportal islet transplantation
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Zhu H, Wang J, Jiang H, Ma Y, Pan S, Reddy S, Sun X
- KMID: 994397
- Exp Mol Med.
- 2010 Nov;42(11):739-748.
- doi: 10.3858/emm.2010.42.11.075
Nonspecific inflammatory response is the major cause for failure of islet grafts at the early phase of intraportal islet transplantation (IPIT). Bilirubin, a natural product of heme catabolism, has displayed... -
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- Current Status and Future Perspectives of Xenotransplantation
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Park CG, Kim JS, Shin JS, Kim YH, Kim SJ
- KMID: 1819842
- J Korean Soc Transplant.
- 2009 Dec;23(3):203-213.
- doi: 10.4285/jkstn.2009.23.3.203
Xenotransplantation using pigs as the transplant source holds great promise to resolve the severe shortage of human organ donors. Although stem-cell-derived organ and tissue regeneration have a potential to solve... -
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- Islet Transplantation vs. Pancreas Transplantation
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Kim JH, Lee MK
- KMID: 2168169
- Hanyang Med Rev.
- 2009 May;29(2):186-192.
Transplantation of whole pancreas has emerged as an effective treatment modality for patients with diabetes mellitus, especially those with established end-stage renal disease. Although surgical and immunosuppressive advances have significantly... -
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- History, current status and perspective of islet transplantation
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Kim JH, Kim KW
- KMID: 2258776
- Korean J Med.
- 2008 Sep;75(3):274-279.
Islet transplantation has been considered as an attractive procedure due to its simplicity, and because it can improve glycemic control in type 1 diabetic patient with hypoglycemic unawareness. In 2000,... -
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- Pancreas and Islet Transplantation in Diabetes
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Han DJ
- KMID: 2185931
- J Korean Med Assoc.
- 2008 Aug;51(8):724-731.
- doi: 10.5124/jkma.2008.51.8.724
Bcell replacement, either by the intact whole pancreas or by an isolated pancreas islet, has become a clinical option to be considered in the treatment of patients with type 1... -
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- Differentiation of Pancreatic beta Cells from Human Pancreatic Duct Cells Derived from a Partial Pancreas Tissue
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Song KH, Kim MM, Lee MK, Ryu GR, Ko SH, Moon SD, Ahn YB, Yoon KH, Cha BY, Lee KW, Son HY, Kang SK, Chin HM
- KMID: 1523012
- J Korean Diabetes Assoc.
- 2007 May;31(3):236-242.
- doi: 10.4093/jkda.2007.31.3.236
BACKGROUND: Despite a recent breakthrough in human islet transplantation for treating diabetes mellitus, the limited availability of insulin-producing tissue is still a major obstacle. This has led to a search... -
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- Effects of Islet Transplantation on Endogenous beta-cell Regeneration after Partial Pancreatectomy in Rodents
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Jung HS, Ahn YR, Oh SH, Jung JH, Kim TH, Hwang YC, Kang M, Bae Y, Kim YS, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 2008079
- J Korean Diabetes Assoc.
- 2007 Mar;31(2):113-122.
- doi: 10.4093/jkda.2007.31.2.113
BACKGROUND: Islet transplantation is one of regimens supplying the deficient insulin in diabetes patients, but the effects of islet grafts on the changes of endogenous beta-cells are not clear. In... -
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- Inducible Nitric Oxide Synthase (iNOS) Expression in the Hypoxic Injury to Pancreatic Beta (MIN6) Cells
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Ko SH, Kim SB, Ryu KR, Kim JW, Ahn YB, Moon SD, Kim SR, Lee JM, Kwon HS, Yoon KH, Song KH
- KMID: 2008263
- J Korean Diabetes Assoc.
- 2006 Sep;30(5):336-346.
- doi: 10.4093/jkda.2006.30.5.336
BACKGROUND: Islet transplantation is an alternative potential strategy to cure type 1 diabetes mellitus. However, two or more donors are usually needed for one recipient because a substantial part of... -
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- Standardization of Isolation Procedure and Analysis of Variables on Successful Isolation of Islet from the Human Pancreas
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Kim SC, Han DJ, Kim IH, We YM, Kim YH, Kim JH, Back JH, Lim DG
- KMID: 2200654
- J Korean Soc Endocrinol.
- 2006 Feb;21(1):22-31.
- doi: 10.3803/jkes.2006.21.1.22
BACKGROUND: Identifying the donor and isolation-related factors during the islet isolation would be greatly helpful to improve the result of human islet isolation for successful clinical islet transplantation. METHODS: Sixty-nine pancreata... -
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- Experimental Study on Cryopreservation of Pancreas Islet Cell in Rat
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Back JH, Kim SC, Kim IH, We YM, Kim YH, Kim JH, Cho IH, Cho EY, Lim DG, Han DJ
- KMID: 2201805
- J Korean Soc Transplant.
- 2005 Dec;19(2):124-130.
PURPOSE: Cryopreservation of pancreas islet cells can facilitate the clinical islet transplantation by giving a means of storage of islets and immunomodulation on pancreatic islet preparations. METHODS: Pancreatic islets were isolated... -
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- Effective Glycemic Control Achieved by the Transplantation of VEGF-Transfected Islets in STZ-induced Diabetic Mice
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Lee BW, Chae HY, Ahn YR, Oh SH, Kim JY, Chung YJ, Kim SY, Cho KY, Chung JH, Min YK, Lee MS, Lee MK, Kim KW
- KMID: 2177756
- J Korean Diabetes Assoc.
- 2005 Jul;29(4):282-294.
BACKGROUND: Hypoxic damage is one of the major causes of early islet graft failure, and VEGF is known to play a crucial role in revascularization. We tried to evaluate whether... -
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- Immune Tolerance in Murine Islet Transplantation Across HY Disparity
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Choi SE, Park CG
- KMID: 2054244
- Immune Netw.
- 2004 Mar;4(1):53-59.
- doi: 10.4110/in.2004.4.1.53
BACKGROUND: Minor histocompatibility HY antigen, as a transplantation antigen, has been known to cause graft rejection in MHC (major histocompatibility complex) matched donor-recipient. The aim of our study is to... -
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