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Identifying pathogenic variants related to systemic lupus erythematosus by integrating genomic databases and a bioinformatic approach

Yudhani RD, Pakha DN, Suyatmi S, Irham LM

Systemic lupus erythematosus (SLE) is an inflammatory-autoimmune disease with a complex multi-organ pathogenesis, and it is known to be associated with significant morbidity and mortality. Various genetic, immunological, endocrine, and...
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A bioinformatic approach to identify pathogenic variants for Stevens-Johnson syndrome

Ma’ruf M, Fadli JC, Mahendra MR, Irham LM, Sulistyani N, Adikusuma W, Chong R, Septama AW

Stevens-Johnson syndrome (SJS) produces a severe hypersensitivity reaction caused by Herpes simplex virus or mycoplasma infection, vaccination, systemic disease, or other agents. Several studies have investigated the genetic susceptibility involved...
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Identification of druggable genes for multiple myeloma based on genomic information

Satria RD, Irham LM, Adikusuma W, Puspitaningrum AN, Afief AR, Khair RE, Septama AW

Multiple myeloma (MM) is a hematological malignancy. It is widely believed that genetic factors play a significant role in the development of MM, as investigated in numerous studies. However, the...
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A genomic and bioinformatic-based approach to identify genetic variants for liver cancer across multiple continents

Ma’ruf M, Irham LM, Adikusuma W, Sarasmita MA, Khairi S, Purwanto BD, Chong R, Mazaya M, Siswanto LMH

Liver cancer is the fourth leading cause of death worldwide. Well-known risk factors include hepatitis B virus and hepatitis C virus, along with exposure to aflatoxins, excessive alcohol consumption, obesity,...
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