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The mutational landscape of hepatocellular carcinoma

Lee JS

The development of hepatocellular carcinoma (HCC) is a complex process, and HCC arises from the accumulation of multiple genetic alterations leading to changes in the genomic landscape. Current advances in...
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Role of phospholipase D1 in glucose-induced insulin secretion in pancreatic beta cells

Ma WN, Park SY, Han JS

As glucose is known to induce insulin secretion in pancreatic beta cells, this study investigated the role of a phospholipase D (PLD)-related signaling pathway in insulin secretion caused by high...
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Double Strand Break of DNA in Gastric Adenoma and Adenocarcinoma

Kim JH, Kim SS, Byun SW, Chang YJ, Kim JS, Kim JK, Cho HJ, Lim KW, Jung ES

BACKGROUND/AIMS: DNA double strand break (DSB) is one of the critical types of DNA damage. When unrepaired DSB is accumulated in the nucleus of the cells having mutations in such...
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