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The Relationship between Neural Foraminal Stenosis and Imaging Features of Lumbar Spine MRI in Patients Older Than 60 Years with Lumbar Radiculopathy

Lee K, Jeong HS, Park C, Kim M, Ryu H, Roh J, Yeom JA, Kim JH, Kim TU, Jeon CH

Purpose To investigate the MRI features associated with neural foraminal stenosis (NFS) in patients older than 60 years with lumbar (L) radiculopathy. Materials and Methods This study included 133 retrospectively selected...
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The Anti-Inflammatory and Cytoprotective Efficiency of Curvularin, a Fungal Macrolactone against Lipopolysaccharide-Induced Inflammatory Response in Nucleus Pulposus Cells: An In Vitro Study

Banala RR, Vemuri SK, EV S, AV GR, GPV S

Study Design: Developing an in vitro model for assessing the anti-inflammatory properties of curvularin. Purpose: To evaluate the efficacy of natural fungal macrolactone as a therapeutic drug against lipopolysaccharide (LPS)-induced inflammation...
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Mechanical Stimulation and Diameter of Fiber Scaffolds Affect the Differentiation of Rabbit Annulus Fibrous Stem Cells

Zhou P, Wei B, Guan J, Chen Y, Zhu Y, Ye Y, Meng Y, Guan J, Mao Y

BACKGROUND: Degeneration of the annulus fibrosus (AF), an important structure of the intervertebral disc, is one of the main causes of degenerative disc disease. Fabrication of scaffolds replicating the stratified...
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A New Classification for Cervical Ossification of the Posterior Longitudinal Ligament Based on the Coexistence of Segmental Disc Degeneration

Lee JK, Ham CH, Kwon WK, Moon HJ, Kim JH, Park YK

Objective : Classification systems for cervical ossification of the posterior longitudinal ligament (OPLL) have traditionally focused on the morphological characteristics of ossification. Although the classification describes many clinical features associated...
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Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc

Rajasekaran S, Soundararajan DCR, Tangavel C, K. S. SVA, Nayagam SM, Matchado MS, Muthurajan R, Shetty AP, Kanna RM, Dharmalingam K

Study Design: Profiling proteins expressed in the nucleus pulposus of fetal intervertebral disc (IVD). Purpose: To evaluate the molecular complexity of fetal IVDs not exposed to mechanical, traumatic, inflammatory, or infective...
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Effect of Conditioned Medium from Human Umbilical Cord-Derived Mesenchymal Stromal Cells on Rejuvenation of Nucleus Pulposus Derived Stem/Progenitor Cells from Degenerated Intervertebral Disc

Zeng X, Lin J, Wu H, Yu J, Tu M, Cheang LH, Zhang J

Background and Objectives: Mesenchymal stromal cells (MSCs)-based treatment for degeneration of intervertebral disc (IVD) has been proposed recently. We here addressed whether MSC secreted factors can rejuvenate nucleus pulposus- derived...
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Relationship Between Endplate Defects, Modic Change, Facet Joint Degeneration, and Disc Degeneration of Cervical Spine

Lee SH, Son DW, Lee JS, Sung SK, Lee SW, Song GS

Objective: The ‘‘disc degeneration precedes facet joint osteoarthritis’’ hypothesis and multidimensional analysis were actively discussed in lumbar spine. However, in cervical spine degeneration, the multifactorial analyzes of disc degeneration (DD),...
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A prediction model of low back pain risk: a population based cohort study in Korea

Mukasa D, Sung J

Background: Well-validated risk prediction models help to identify individuals at high risk of diseases and suggest preventive measures. A recent systematic review reported lack of validated prediction models for low...
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Significance of the Association between Disc Degeneration Changes on Imaging and Low Back Pain: A Review Article

Rahyussalim AJ, Zufar MLL, Kurniawati T

Low back pain (LBP) is a major health issue resulting in a huge economic burden on the community. It not only increases the medical costs directly, but also raises the...
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The Impact of Modic Changes on Preoperative Symptoms and Clinical Outcomes in Anterior Cervical Discectomy and Fusion Patients

Baker JD, Harada GK, Tao Y, Louie PK, Basques BA, Galbusera , Niemeyer F, Wilke HJ, An HS, Samartzis

Objective: To assess the impact of Modic changes (MC) on preoperative symptoms, and postoperative outcomes in anterior cervical discectomy and fusion (ACDF) patients. Methods: We performed a retrospective study of prospectively...
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Rabbit Annulus Fibrosus Cells Express Neuropeptide Y, Which Is Influenced by Mechanical and Inflammatory Stress

Dombrowski ME, Olsen AS, Vaudreuil , Couch BK, Dong Q, Tucci M, Lee JY, Vo NV, Sowa G

Objective: Rabbit annulus fibrosus (AF) cells were exposed to isolated or combined mechanical and inflammatory stress to examine the expression of neuropeptide Y (NPY). This study aims to explore the...
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Gene Therapy Approach for Intervertebral Disc Degeneration: An Update

Takeoka Y, Yurube T, Nishida K

Intervertebral disc degeneration is the primary cause of back pain and associated with neurological disorders including radiculopathy, myelopathy, and paralysis. The currently available surgical treatments predominantly include the excision of...
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Relevance between Schmorl’s Node and Lumbar Intervertebral Disc Degeneration Quantified with Magnetic Resonance Imaging T2 Mapping in Chronic Low Back Pain

Ogon I, Takashima H, Morita T, Oshigiri T, Terashima Y, Yoshimoto M, Fukushi R, Fujimoto S, Emori M, Teramoto A, Takebayashi T, Yamashita T

Study Design: Cross-sectional study. Purpose: The purpose of this study was to elucidate the relevance among Schmorl’s node (SN), chronic low back pain (CLBP), and intervertebral disc degeneration (IVDD) with the...
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Is Adjacent Segment Disease More Frequent in Proximal Levels in Comparison with Distal Levels? Based on Radiological Data of at Least 2 Years Follow Up with More than 2 Level Thoracolumbar Fusions

Kim JH, Ryu DS, Yoon SH

OBJECTIVE: The purpose of this retrospective study was to determine which of the proximal adjacent segment disease (ASD) and distal ASD was more prevalent and what parameters is more related...
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Correlation of Cervical Disc Degeneration with Sagittal Alignments of Cervical Spine

Jeon DG, Park J, Park JH, Yun WH

OBJECTIVE: To determine the relationship between cervical sagittal parameters and the degree of the cervical disc degeneration at each cervical level by using cervical plain radiographs and disc degeneration grading. METHOD:...
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Evaluation of Anti-inflammatory and Regenerative Efficiency of Naringin and Naringenin in Degenerated Human Nucleus Pulposus Cells: Biological and Molecular Modeling Studies

Devraj VM, Vemuri SK, Banala RR, Gunda SK, AV GR, GPV S

STUDY DESIGN: Development of an in vitro model for assessing the anti-inflammatory efficacies of naringin (Nar) and naringenin (NG). PURPOSE: To evaluate the efficacy of natural flavonoids as therapeutic drugs against...
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Comparison of Transforming Growth Factor-Beta1 and Lovastatin on Differentiating Mesenchymal Stem Cells toward Nucleus Pulposus-like Phenotype: An In Vitro Cell Culture Study

Yang SH, Yang KC, Chen CW, Huang TC, Sun YH, Hu MH

STUDY DESIGN: In Vitro cell culture study. PURPOSE: This study aims to investigate the impact of transforming growth factor-beta1 (TGF-β1) and lovastatin on differentiating human mesenchymal stem cells (MSCs) toward nucleus...
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Dual-Layer Spectral Detector CT Discography of the Lumbar Spine: A Preliminary Study

Chae HD, Hong SH, Choi JY, Yoo HJ, Moon SJ, Chang MY

PURPOSE: To assess the feasibility of spectral detector CT (SDCT) with axial maximum-intensity projection (MIP) reconstruction for the evaluation of lumbar CT discography. MATERIALS AND METHODS: We retrospectively evaluated 44 disc...
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In Vitro Biomechanical and Fluoroscopic Study of a Continuously Expandable Interbody Spacer Concerning Its Role in Insertion Force and Segmental Kinematics

Torretti J, Harris JA, Bucklen BS, Moldavsky , Khalil SE

STUDY DESIGN: In vitro cadaveric study. PURPOSE: To compare biomechanical performance, trial and implant insertion, and disc distraction during implant placement, when two interbody devices, an in situ continuously expandable spacer...
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Clinical Relationship of Degenerative Changes between the Cervical and Lumbar Spine

Morishita , Buser Z, D'Oro A, Shiba K, Wang JC

STUDY DESIGN: Retrospective, observational, case series. PURPOSE: To elucidate the prevalence of degenerative changes in the cervical and lumbar spine and estimate the degenerative changes in the cervical spine based on...
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