- Association between interstitial cells of Cajal and anti-vinculin antibody in human stomach
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Kim JH, Nam SJ, Park SC, Lee SH, Kim TS, Lee M, Park JM, Choi DH, Kang CD, Lee SJ, Ryu YJ, Lee K, Park SY
- KMID: 2471040
- Korean J Physiol Pharmacol.
- 2020 Mar;24(2):185-191.
- doi: 10.4196/kjpp.2020.24.2.185
Interstitial cells of Cajal (ICC) are known as the pacemaker cells of gastrointestinal tract, and it has been reported that acute gastroenteritis induces intestinal dysmotility through antibody to vinculin, a... -
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- Colonic Dysmotility in Murine Partial Colonic Obstruction Due to Functional Changes in Interstitial Cells
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Wang Q, Zang J, Huang X, Lu H, Xu W, Chen J
- KMID: 2460488
- J Neurogastroenterol Motil.
- 2019 Oct;25(4):589-601.
- doi: 10.5056/jnm19136
BACKGROUND/AIMS: Interstitial cells play important roles in gastrointestinal (GI) neuro-smooth muscle transmission. The underlying mechanisms of colonic dysmotility have not been well illustrated. We established a partial colon obstruction (PCO)... -
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- Colonic Transit Disorder Mediated by Downregulation of Interstitial Cells of Cajal/Anoctamin-1 in Dextran Sodium Sulfate-induced Colitis Mice
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Lu C, Lu H, Huang X, Liu S, Zang J, Li Y, Chen J, Xu W
- KMID: 2449103
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):316-331.
- doi: 10.5056/jnm18173
BACKGROUND/AIMS: Interstitial cells of Cajal (ICC) and their special calcium-activated chloride channel, anoctamin-1 (ANO1) play pivotal roles in regulating colonic transit. This study is designed to investigate the role of... -
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- High-resolution Mapping of Hyperglycemia-induced Gastric Slow Wave Dysrhythmias
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Du P, O'Grady G, Paskaranandavadivel N, Tang SJ, Abell T, Cheng LK
- KMID: 2449100
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):276-285.
- doi: 10.5056/jnm18192
BACKGROUND/AIMS: It is now recognised that gastric dysrhythmias are best characterised by their spatial propagation pattern. Hyperglycemia is an important cause of gastric slow wave dysrhythmia, however, the spatiotemporal patterns... -
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- Control of Motility in the Internal Anal Sphincter
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Keef KD, Cobine CA
- KMID: 2449091
- J Neurogastroenterol Motil.
- 2019 Apr;25(2):189-204.
- doi: 10.5056/jnm18172
The internal anal sphincter (IAS) plays an important role in the maintenance of fecal continence since it generates tone and is responsible for > 70% of resting anal pressure. During... -
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- Overexpression of Stromal Interaction Molecule 1/Store-operated Calcium Entry-associated Regulatory Factor in Interstitial Cells of Cajal in Mouse Jejunum Impairs Pacemaker Activity
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Jian-Lin L, Chen NY, Pan SL
- KMID: 2422858
- J Neurogastroenterol Motil.
- 2018 Oct;24(4):678-680.
- doi: 10.5056/jnm18066
No abstract available. -
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- Role of High-affinity Choline Transporter 1 in Colonic Hypermotility in a Rat Model of Irritable Bowel Syndrome
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Lin MJ, Yu BP
- KMID: 2422854
- J Neurogastroenterol Motil.
- 2018 Oct;24(4):643-655.
- doi: 10.5056/jnm18040
BACKGROUND/AIMS: Irritable bowel syndrome (IBS) is a common disease characterized by intestinal dysmotility, the mechanism of which remains elusive. We aim to determine whether the high-affinity choline transporter 1 (CHT1),... -
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- Aging Decreases the Density of Colonic Interstitial Cells of Cajal Associated With Constipation in Rats
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Xiao J
- KMID: 2413110
- J Neurogastroenterol Motil.
- 2018 Apr;24(2):326-328.
- doi: 10.5056/jnm18016
No abstract available. -
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- Effects of ATP on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Small Intestine
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Park IK, Kim JH, Park CG, Kim MY, Parajuli S, Hong CS, Choi S, Jun JY
- KMID: 2458587
- Chonnam Med J.
- 2018 Jan;54(1):63-71.
- doi: 10.4068/cmj.2018.54.1.63
Purinergic receptors play an important role in regulating gastrointestinal (GI) motility. Interstitial cells of Cajal (ICCs) are pacemaker cells that regulate GI smooth muscle activity. We studied the functional roles... -
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- Regulation of Intracellular Calcium by Endoplasmic Reticulum Proteins in Small Intestinal Interstitial Cells of Cajal
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Park CG, Wu MJ, Hong C, Jo JY, Jiao HY, Park H, Jun JY, Choi S
- KMID: 2417280
- J Neurogastroenterol Motil.
- 2018 Jan;24(1):128-137.
- doi: 10.5056/jnm16212
BACKGROUND/AIMS: We investigated the role of representative endoplasmic reticulum proteins, stromal interaction molecule 1 (STIM1), and store-operated calcium entry-associated regulatory factor (SARAF) in pacemaker activity in cultured interstitial cells of... -
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- Comparison of Changes in the Interstitial Cells of Cajal and Neuronal Nitric Oxide Synthase-positive Neuronal Cells With Aging Between the Ascending and Descending Colon of F344 Rats
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Lee SM, Kim N, Jo HJ, Park JH, Nam RH, Lee HS, Kim HJ, Lee MY, Kim YS, Lee DH
- KMID: 2395429
- J Neurogastroenterol Motil.
- 2017 Oct;23(4):592-605.
- doi: 10.5056/jnm17061
BACKGROUND/AIMS: Neuronal degeneration and changes in interstitial cells of Cajal (ICCs) are important mechanisms of age-related constipation. This study aims to compare the distribution of ICCs and neuronal nitric oxide... -
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- Slow Wave Activity and Modulations in Mouse Jejunum Myenteric Plexus In Situ
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Cai Y, Tang H, Jiang F, Dong Z
- KMID: 2367463
- J Neurogastroenterol Motil.
- 2017 Jan;23(1):117-123.
- doi: 10.5056/jnm16012
BACKGROUND/AIMS: Myenteric plexus interstitial cells of Cajal (ICC-MY) are involved in the generation of gut pacemaker activity and neuronal communication. We performed patch clamp on ICC-MY in situ to observe... -
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- Neurotensin Changes Propulsive Activity into a Segmental Motor Pattern in the Rat Colon
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Li H, Chen JH, Yang Z, Huang M, Yu Y, Tan S, Luo H, Huizinga J
- KMID: 2327958
- J Neurogastroenterol Motil.
- 2016 Jul;22(3):517-528.
- doi: 10.5056/jnm15181
BACKGROUND/AIMS: Neurotensin is a gut-brain peptide with both inhibitory and excitatory actions on the colonic musculature; our objective was to understand the implications of this for motor patterns occurring in... -
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- Molecular and Cellular Characteristics of the Colonic Pseudo-obstruction in Patients With Intractable Constipation
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Do YS, Myung SJ, Kwak SY, Cho S, Lee E, Song MJ, Yu CS, Yoon YS, Lee HK
- KMID: 2381305
- J Neurogastroenterol Motil.
- 2015 Oct;21(4):560-570.
- doi: 10.5056/jnm15048
BACKGROUND/AIMS: Chronic intestinal pseudo-obstruction (CIPO) is a disorder characterized by recurrent symptoms suggestive of obstruction such as abdominal pain, proximal distension with extremely suppressed motility in the absence of lumen-occluding... -
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- Targeting Ion Channels: An Important Therapeutic Implication in Gastrointestinal Dysmotility in Patients With Spinal Cord Injury
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Radulovic , Anand P, Korsten MA, Gong B
- KMID: 2381297
- J Neurogastroenterol Motil.
- 2015 Oct;21(4):494-502.
- doi: 10.5056/jnm15061
Gastrointestinal (GI) dysmotility is a severe, and common complication in patients with spinal cord injury (SCI). Current therapeutic methods using acetylcholine analogs or laxative agents have unwanted side effects, besides... -
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- Is Interstitial Cells of Cajal-opathy Present in Gastroparesis?
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Bashashati M, McCallum R
- KMID: 2381296
- J Neurogastroenterol Motil.
- 2015 Oct;21(4):486-493.
- doi: 10.5056/jnm15075
Gastroparesis (GP), defined as delayed gastric emptying in the absence of any mechanical obstruction, is a challenging clinical condition, mainly because of limited treatment options. Studies in animal models of... -
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- Pituitary Adenylate Cyclase-activating Polypeptide Inhibits Pacemaker Activity of Colonic Interstitial Cells of Cajal
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Wu MJ, Kee KH, Na J, Kim SW, Bae Y, Shin DH, Choi S, Jun JY, Jeong HS, Park JS
- KMID: 2285588
- Korean J Physiol Pharmacol.
- 2015 Sep;19(5):435-440.
- doi: 10.4196/kjpp.2015.19.5.435
This study aimed to investigate the effect of pituitary adenylate cyclase-activating peptide (PACAP) on the pacemaker activity of interstitial cells of Cajal (ICC) in mouse colon and to identify the... -
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- Alterations of Colonic Contractility in an Interleukin-10 Knockout Mouse Model of Inflammatory Bowel Disease
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Park JH, Kwon JG, Kim SJ, Song DK, Lee SG, Kim ES, Cho KB, Jang BI, Kim DH, Sin JI, Kim TW, Song IH, Park KS
- KMID: 2381231
- J Neurogastroenterol Motil.
- 2015 Jan;21(1):51-61.
- doi: 10.5056/jnm14008
BACKGROUND/AIMS: Inflammatory bowel disease is commonly accompanied by colonic dysmotility and causes changes in intestinal smooth muscle contractility. In this study, colonic smooth muscle contractility in a chronic inflammatory condition... -
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- Does Decreased c-KIT Expression in Myenteric Interstitial Cells of Cajal Cause Decreased Spontaneous Contraction in Murine Proximal Colon?
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Lee MY
- KMID: 2381226
- J Neurogastroenterol Motil.
- 2015 Jan;21(1):1-3.
- doi: 10.5056/jnm14140
No abstract available. -
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- Effects of Lubiprostone on Pacemaker Activity of Interstitial Cells of Cajal from the Mouse Colon
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Jiao HY, Kim DH, Ki JS, Ryu KH, Choi S, Jun JY
- KMID: 2285529
- Korean J Physiol Pharmacol.
- 2014 Aug;18(4):341-346.
- doi: 10.4196/kjpp.2014.18.4.341
Lubiprostone is a chloride (Cl-) channel activator derived from prostaglandin E1 and used for managing constipation. In addition, lubiprostone affects the activity of gastrointestinal smooth muscles. Interstitial cells of Cajal... -
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