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Effects of Paroxetine on a Human Ether-a-go-go-related Gene (hERG) K⁺ Channel Expressed in Xenopus Oocytes and on Cardiac Action Potential

Hong HK, Hwang S, Jo SH

  • Int J Oral Biol.
  • 2018 Mar;43(1):43-51.
  • doi: 10.11620/IJOB.2018.43.1.043
K⁺ channels are key components of the primary and secondary basolateral Cl- pump systems, which are important for secretion from the salivary glands. Paroxetine is a selective serotonin reuptake inhibitor...
The Ethanol Extract of Croton Seed Inhibits the Oral Pathogen, Streptococcus mutans

Kim JH, Jung SS, Kang CH, You YO, Kim KJ

  • Int J Oral Biol.
  • 2018 Mar;43(1):37-42.
  • doi: 10.11620/IJOB.2018.43.1.037
It is noted that Streptococcus mutans (S. mutans) triggers dental caries establishment by two major factors: the synthesis of organic acids, which demineralize dental enamel, and the synthesis of glucans,...
The Regulatory Effects of Trans-chalcone on Adipogenesis

Han Y

  • Int J Oral Biol.
  • 2018 Mar;43(1):29-35.
  • doi: 10.11620/IJOB.2018.43.1.029
It is noted that chalcone derivatives have characteristic diverse pharmacological properties, and that precise evidence has been growing that they could regulate a tumor necrosis factor-α (TNF-α) induced insulin resistance....
Channel Function of TRPML1 Prompts Lipolysis in Mature Adipocytes

Kim MS, Kim MS

  • Int J Oral Biol.
  • 2018 Mar;43(1):23-27.
  • doi: 10.11620/IJOB.2018.43.1.023
Increased intracellular levels of Ca²⁺ are generally thought to negatively regulate lipolysis in mature adipocytes, whereas store-operated Ca²⁺ entry was recently reported to facilitate lipolysis and attenuate lipotoxicity by inducing...
Changes in Oral Microbiota in Patients Receiving Radical Concurrent Chemoradiotherapy for The Head and Neck Squamous Cell Carcinoma

Kim JH, Choi YH, An SY, Son HY, Choi C, Kim S, Chung J, Na HS

  • Int J Oral Biol.
  • 2018 Mar;43(1):13-21.
  • doi: 10.11620/IJOB.2018.43.1.013
Radiotherapy (RT) is a mainstay in the treatment of head and neck squamous cell carcinoma (HNSCC). For locally advanced HCSCC, concurrent chemoradiotherapy (CCRT) benefits HCSCC patients in terms of better...
An Expression Levels Analysis of the Bitter Taste Receptors in the Murine Exocrine Glands

Ki SY, Cho YK, Chung KM, Kim KN

  • Int J Oral Biol.
  • 2018 Mar;43(1):5-11.
  • doi: 10.11620/IJOB.2018.43.1.005
Recent findings indicate that Type 2 taste receptors (T2Rs) are expressed outside the gustatory system, including in the gastrointestinal tracts and the exocrine glands, such as the submandibular (SM), parotid...
Blockchain Revolution in Healthcare : The Era of Patient-centered Dental Information System

Kho W

  • Int J Oral Biol.
  • 2018 Mar;43(1):1-3.
  • doi: 10.11620/IJOB.2018.43.1.001
Blockchain is at the center of attention recently and it is expected to have a huge impact on healthcare industry including dentistry as well. Blockchain is a fundamental technology behind...

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