- Dendritic cells resist to disulfiram-induced cytotoxicity, but reduced interleukin-12/23(p40) production
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Jung H, Joo HG
- KMID: 2545537
- Korean J Physiol Pharmacol.
- 2023 Sep;27(5):471-479.
- doi: 10.4196/kjpp.2023.27.5.471
Disulfiram (DSF), a medication for alcoholism, has recently been used as a repurposing drug owing to its anticancer effects. Despite the crucial role of dendritic cells (DCs) in immune homeostasis... -
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- IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment
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Choi JN, Sun EG, Cho SH
- KMID: 2432253
- Chonnam Med J.
- 2019 Jan;55(1):31-39.
- doi: 10.4068/cmj.2019.55.1.31
Myeloid derived suppressor cells (MDSCs) are a heterogenous population of immature cells that play a critical role in tumor associated immune suppression. In tumor conditions, the population of MDSCs increases.... -
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- Novel treatments for inflammatory bowel disease
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Lee HS, Park SK, Park DI
- KMID: 2411506
- Korean J Intern Med.
- 2018 Jan;33(1):20-27.
- doi: 10.3904/kjim.2017.393
Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of... -
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- Efficacy and safety of ustekinumab in Japanese patients with moderately to severely active Crohn's disease: a subpopulation analysis of phase 3 induction and maintenance studies
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Hibi T, Imai Y, Murata Y, Matsushima N, Zheng R, Gasink C
- KMID: 2396397
- Intest Res.
- 2017 Oct;15(4):475-486.
- doi: 10.5217/ir.2017.15.4.475
BACKGROUND/AIMS: Efficacy and safety of ustekinumab were evaluated in a Japanese subpopulation with moderately to severely active Crohn's disease (CD) in UNITI-1, UNITI-2 and IM-UNITI studies and results were compared... -
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- Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity
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Kim HJ, Park SM, Lee H, Kim YS
- KMID: 2355024
- Immune Netw.
- 2016 Oct;16(5):305-310.
- doi: 10.4110/in.2016.16.5.305
In this study, we compared two different tumor cell vaccines for their induction of anti-tumor immunity; one was a tumor cell clone expressing a membrane-bound form of IL-12 p35 subunit... -
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- Tumor Cell Clone Expressing the Membrane-bound Form of IL-12p35 Subunit Stimulates Antitumor Immune Responses Dominated by CD8+ T Cells
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Lim H, Do SA, Park SM, Kim YS
- KMID: 1431927
- Immune Netw.
- 2013 Apr;13(2):63-69.
- doi: 10.4110/in.2013.13.2.63
IL-12 is a secretory heterodimeric cytokine composed of p35 and p40 subunits. IL-12 p35 and p40 subunits are sometimes produced as monomers or homodimers. IL-12 is also produced as a... -
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- Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine
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Lee JS, Kim DH, Lee CM, Ha TK, Noh KT, Park JW, Heo DR, Son KH, Jung ID, Lee EK, Shin YK, Ahn SC, Park YM
- KMID: 2150695
- Immune Netw.
- 2011 Feb;11(1):79-94.
- doi: 10.4110/in.2011.11.1.79
BACKGROUND: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is difficult. Here, we... -
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- The Effect of Gefitinib on Immune Response of Human Peripheral Blood Monocyte-Derived Dendritic Cells
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Cho JH, Kim MH, Lee KH, Kim KU, Jeon DS, Park HK, Kim YS, Lee MK, Park SK
- KMID: 2319456
- Tuberc Respir Dis.
- 2010 Dec;69(6):456-464.
BACKGROUND: Synergistic antitumor effects of the combined chemoimmunotherapy based on dendritic cells have been reported recently. The aim of this study is to search new applicability of gefitinib into the... -
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- IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model
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Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK
- KMID: 1104380
- Exp Mol Med.
- 2010 Aug;42(8):533-546.
- doi: 10.3858/emm.2010.42.8.054
IL-4 and IL-13 are closely related cytokines that are produced by Th2 cells. However, IL-4 and IL-13 have different effects on the development of asthma phenotypes. Here, we evaluated downstream... -
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- IL-12 p40-Expressing Immune Cells Revealed by Cytokine Reporter Mouse System
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Gi M, Kim J, Im W, Youn J, Hong S
- KMID: 2283675
- Korean J Phys Anthropol.
- 2009 Mar;22(1):95-105.
Interleukin-12 (IL-12), consisting of p35 and p40, plays important roles in linking innate and adaptive immunity. While p35 is constitutively expressed, IL-12 p40 gene expression is induced upon activation by... -
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- Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers
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Im SJ, Yang SH, Yoon SK, Sung YC
- KMID: 2167993
- Immune Netw.
- 2009 Feb;9(1):20-26.
- doi: 10.4110/in.2009.9.1.20
BACKGROUND: We previously reported that IFN-gamma producing T cell responses induced by the combined therapy of DNA vaccine and lamivudine for one year are important for the induction of sustained... -
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- Association of Interleukin-12 Gene Polymorphism with Persistence of Hepatitis B Virus Infection and Hepatocellular Carcinoma
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Park JS, Cheong JY, Kang JK, Cho JH, Yu S, Shin HD, Park BL, Cho SW
- KMID: 782935
- Korean J Gastroenterol.
- 2007 Nov;50(5):313-318.
BACKGROUND/AIMS: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection is influenced by various host immune factors and cytokines play a crucial... -
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- Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia
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Park JY, Kim JY, Cho SJ, Kim YJ, Park HS, Ha EH, Park EA
- KMID: 2279243
- Korean J Pediatr.
- 2007 Mar;50(3):248-254.
- doi: 10.3345/kjp.2007.50.3.248
PURPOSE: Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood... -
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- mRNA Expression and RNA Editing (2451 C-to-U) of IL-12 Receptor beta2 in Adult Atopic Patients
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Kim EJ, Lee WM, Ha JS, Ryoo NH, Jeon DS, Kim JR
- KMID: 1713121
- J Korean Med Sci.
- 2006 Dec;21(6):1070-1074.
- doi: 10.3346/jkms.2006.21.6.1070
Interleukin (IL)-12 activates T helper (Th) 1 cells to produce interferon (IFN)-gamma which inhibits atopic inflammation. IL-12 acts through interaction with its receptor, especially beta2 subunit. In several studies, the... -
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- TNF-alpha and IL-12 Secretion in Macrophages in Response to Spores of Bacillus anthracis Sterne
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Baek JJ, Jung KH, Chai YG
- KMID: 2055021
- J Bacteriol Virol.
- 2006 Sep;36(3):141-150.
- doi: 10.4167/jbv.2006.36.3.141
Baerobic, spore forming, and rod-shaped bacterium. Anthrax spores are introduced into macrophage by phagocytosis and multiply after germination. The anthrax spores infected in macrophage produce lethal toxin eventually caused cell... -
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- Depression of Both Interferon-gamma and Tumor Necrosis Factor-alpha Production by Peripheral Blood Mononuclear Cells from Chronic Refractory Tuberculosis Patients
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Lee JS, Lee SH, Song CH, Lim JH, Kim HJ, Park JK, Paik TH, Kim CH, Kong SJ, Shon MH, Jo EK
- KMID: 2054961
- J Bacteriol Virol.
- 2002 Dec;32(4):393-400.
Understanding human immune responses in chronic refractory tuberculosis (CRTB) is important for developing immunotherapy against the disease. The aim of this study was to examine cytokine responses [interferon (IFN)-gamma, tumor... -
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- Dysregulated Production of IFN-g, IL-12, and IL-10 by Peripheral Blood Mononuclear Cells from Early Active Pulmonary and Multidrug-Resistant Tuberculosis Patients
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Lee JS, Son HS, Song CH, Kim HJ, Park JK, Paik TH, Suhr JW, Kim CH, Kong SJ, Shon MH, Jo EK
- KMID: 1573031
- J Bacteriol Virol.
- 2002 Jun;32(2):211-220.
In this study, we investigated profiles of the cytokines IFN-g, IL-12, and IL-10 in active pulmonary tuberculosis (EAPTB) patients, HIV-negative patients with multidrug-resistant tuberculosis (MDR-TB) and in healthy tuberculin reactors... -
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- The Effect of Interleukin-12 on the Immune Response in Allergic Rhinitis Mouse Model
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Kang SM, Ryu HY, Lee JH
- KMID: 2314241
- Pediatr Allergy Respir Dis.
- 2001 Sep;11(3):213-223.
PURPOSE: Interleukin-12, produced by tissue macrophages and B lymphocytes, stimulates proliferation of Th1-type cells, while inhibiting the generation of Th2- type cytokines and IgE production. The mice were sensitized and... -
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- Increased IL-12 , but Depressed IL-18 Production after In Vitro Stimulation with a 30-kDa Mycobacterial Antigen in Tuberculous Pleural Mononuclear Cells
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Song CH, Jo EK, Kim SH, Kim HJ, Suhr JW, Paik TH, Nam HH, Lim JH, Kim UO, Lee JS, Park JK
- KMID: 1571506
- J Bacteriol Virol.
- 2001 Sep;31(3):239-248.
In this study, we investigated interleukin (IL)-18 and IL-12 following in vitro stimulation with either the 30-kDa or purified protein derivative (PPD) antigens (Ag) of pleural mononuclear cells from 12... -
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- Effect of substance P on production of interleukin-12 and interferon-gamma from peripheral blood mononuclear cells of chronic severe atopic dermatitis patients
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Lim JH, Kang H, Park YM, Cho SH, Lee SY
- KMID: 2285932
- J Asthma Allergy Clin Immunol.
- 2001 Aug;21(4):636-646.
BACKGROUND: In atopic patients, allergen-specific T cells express the Th2 phenotype. It is known that interleukin-12 (IL-12) is a major cytokine for the induction of Th1 responses and that a... -
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