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Dendritic cells resist to disulfiram-induced cytotoxicity, but reduced interleukin-12/23(p40) production

Jung H, Joo HG

Disulfiram (DSF), a medication for alcoholism, has recently been used as a repurposing drug owing to its anticancer effects. Despite the crucial role of dendritic cells (DCs) in immune homeostasis...
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IL-12 Enhances Immune Response by Modulation of Myeloid Derived Suppressor Cells in Tumor Microenvironment

Choi JN, Sun EG, Cho SH

Myeloid derived suppressor cells (MDSCs) are a heterogenous population of immature cells that play a critical role in tumor associated immune suppression. In tumor conditions, the population of MDSCs increases....
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Novel treatments for inflammatory bowel disease

Lee HS, Park SK, Park DI

Increased understanding of the immunopathology of inflammatory bowel disease (IBD) has led to the development of targeted therapies and has unlocked a new era in IBD treatment. The development of...
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Efficacy and safety of ustekinumab in Japanese patients with moderately to severely active Crohn's disease: a subpopulation analysis of phase 3 induction and maintenance studies

Hibi T, Imai Y, Murata Y, Matsushima N, Zheng R, Gasink C

BACKGROUND/AIMS: Efficacy and safety of ustekinumab were evaluated in a Japanese subpopulation with moderately to severely active Crohn's disease (CD) in UNITI-1, UNITI-2 and IM-UNITI studies and results were compared...
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Membrane-bound p35 Subunit of IL-12 on Tumor Cells is Functionally Equivalent to Membrane-bound Heterodimeric Single Chain IL-12 for Induction of Anti-tumor Immunity

Kim HJ, Park SM, Lee H, Kim YS

In this study, we compared two different tumor cell vaccines for their induction of anti-tumor immunity; one was a tumor cell clone expressing a membrane-bound form of IL-12 p35 subunit...
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Tumor Cell Clone Expressing the Membrane-bound Form of IL-12p35 Subunit Stimulates Antitumor Immune Responses Dominated by CD8+ T Cells

Lim H, Do SA, Park SM, Kim YS

IL-12 is a secretory heterodimeric cytokine composed of p35 and p40 subunits. IL-12 p35 and p40 subunits are sometimes produced as monomers or homodimers. IL-12 is also produced as a...
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Deoxypodophyllotoxin Induces a Th1 Response and Enhances the Antitumor Efficacy of a Dendritic Cell-based Vaccine

Lee JS, Kim DH, Lee CM, Ha TK, Noh KT, Park JW, Heo DR, Son KH, Jung ID, Lee EK, Shin YK, Ahn SC, Park YM

BACKGROUND: Dendritic cell (DC)-based vaccines are currently being evaluated as a novel strategy for tumor vaccination and immunotherapy. However, inducing long-term regression in established tumor-implanted mice is difficult. Here, we...
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The Effect of Gefitinib on Immune Response of Human Peripheral Blood Monocyte-Derived Dendritic Cells

Cho JH, Kim MH, Lee KH, Kim KU, Jeon DS, Park HK, Kim YS, Lee MK, Park SK

  • KMID: 2319456
  • Tuberc Respir Dis.
  • 2010 Dec;69(6):456-464.
BACKGROUND: Synergistic antitumor effects of the combined chemoimmunotherapy based on dendritic cells have been reported recently. The aim of this study is to search new applicability of gefitinib into the...
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IL-12-STAT4-IFN-gamma axis is a key downstream pathway in the development of IL-13-mediated asthma phenotypes in a Th2 type asthma model

Kim YS, Choi SJ, Choi JP, Jeon SG, Oh SY, Lee BJ, Gho YS, Lee CG, Zhu Z, Elias JA, Kim YK

IL-4 and IL-13 are closely related cytokines that are produced by Th2 cells. However, IL-4 and IL-13 have different effects on the development of asthma phenotypes. Here, we evaluated downstream...
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IL-12 p40-Expressing Immune Cells Revealed by Cytokine Reporter Mouse System

Gi M, Kim J, Im W, Youn J, Hong S

  • KMID: 2283675
  • Korean J Phys Anthropol.
  • 2009 Mar;22(1):95-105.
Interleukin-12 (IL-12), consisting of p35 and p40, plays important roles in linking innate and adaptive immunity. While p35 is constitutively expressed, IL-12 p40 gene expression is induced upon activation by...
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Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers

Im SJ, Yang SH, Yoon SK, Sung YC

BACKGROUND: We previously reported that IFN-gamma producing T cell responses induced by the combined therapy of DNA vaccine and lamivudine for one year are important for the induction of sustained...
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Association of Interleukin-12 Gene Polymorphism with Persistence of Hepatitis B Virus Infection and Hepatocellular Carcinoma

Park JS, Cheong JY, Kang JK, Cho JH, Yu S, Shin HD, Park BL, Cho SW

  • KMID: 782935
  • Korean J Gastroenterol.
  • 2007 Nov;50(5):313-318.
BACKGROUND/AIMS: Infection with hepatitis B virus (HBV) may result in various conditions. Natural course of HBV infection is influenced by various host immune factors and cytokines play a crucial...
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Cord blood IL-10, IL-12 in preterm newborns as predictors of respiratory distress syndrome and bronchopulmonary dysplasia

Park JY, Kim JY, Cho SJ, Kim YJ, Park HS, Ha EH, Park EA

PURPOSE: Inflammation plays a major role in the pathogenesis of RDS and BPD in the immature lung. We investigated the possible role of IL-10 and IL-12 in the cord blood...
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mRNA Expression and RNA Editing (2451 C-to-U) of IL-12 Receptor beta2 in Adult Atopic Patients

Kim EJ, Lee WM, Ha JS, Ryoo NH, Jeon DS, Kim JR

Interleukin (IL)-12 activates T helper (Th) 1 cells to produce interferon (IFN)-gamma which inhibits atopic inflammation. IL-12 acts through interaction with its receptor, especially beta2 subunit. In several studies, the...
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TNF-alpha and IL-12 Secretion in Macrophages in Response to Spores of Bacillus anthracis Sterne

Baek JJ, Jung KH, Chai YG

Baerobic, spore forming, and rod-shaped bacterium. Anthrax spores are introduced into macrophage by phagocytosis and multiply after germination. The anthrax spores infected in macrophage produce lethal toxin eventually caused cell...
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Depression of Both Interferon-gamma and Tumor Necrosis Factor-alpha Production by Peripheral Blood Mononuclear Cells from Chronic Refractory Tuberculosis Patients

Lee JS, Lee SH, Song CH, Lim JH, Kim HJ, Park JK, Paik TH, Kim CH, Kong SJ, Shon MH, Jo EK

  • KMID: 2054961
  • J Bacteriol Virol.
  • 2002 Dec;32(4):393-400.
Understanding human immune responses in chronic refractory tuberculosis (CRTB) is important for developing immunotherapy against the disease. The aim of this study was to examine cytokine responses [interferon (IFN)-gamma, tumor...
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Dysregulated Production of IFN-g, IL-12, and IL-10 by Peripheral Blood Mononuclear Cells from Early Active Pulmonary and Multidrug-Resistant Tuberculosis Patients

Lee JS, Son HS, Song CH, Kim HJ, Park JK, Paik TH, Suhr JW, Kim CH, Kong SJ, Shon MH, Jo EK

  • KMID: 1573031
  • J Bacteriol Virol.
  • 2002 Jun;32(2):211-220.
In this study, we investigated profiles of the cytokines IFN-g, IL-12, and IL-10 in active pulmonary tuberculosis (EAPTB) patients, HIV-negative patients with multidrug-resistant tuberculosis (MDR-TB) and in healthy tuberculin reactors...
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The Effect of Interleukin-12 on the Immune Response in Allergic Rhinitis Mouse Model

Kang SM, Ryu HY, Lee JH

  • KMID: 2314241
  • Pediatr Allergy Respir Dis.
  • 2001 Sep;11(3):213-223.
PURPOSE: Interleukin-12, produced by tissue macrophages and B lymphocytes, stimulates proliferation of Th1-type cells, while inhibiting the generation of Th2- type cytokines and IgE production. The mice were sensitized and...
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Increased IL-12 , but Depressed IL-18 Production after In Vitro Stimulation with a 30-kDa Mycobacterial Antigen in Tuberculous Pleural Mononuclear Cells

Song CH, Jo EK, Kim SH, Kim HJ, Suhr JW, Paik TH, Nam HH, Lim JH, Kim UO, Lee JS, Park JK

  • KMID: 1571506
  • J Bacteriol Virol.
  • 2001 Sep;31(3):239-248.
In this study, we investigated interleukin (IL)-18 and IL-12 following in vitro stimulation with either the 30-kDa or purified protein derivative (PPD) antigens (Ag) of pleural mononuclear cells from 12...
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Effect of substance P on production of interleukin-12 and interferon-gamma from peripheral blood mononuclear cells of chronic severe atopic dermatitis patients

Lim JH, Kang H, Park YM, Cho SH, Lee SY

  • KMID: 2285932
  • J Asthma Allergy Clin Immunol.
  • 2001 Aug;21(4):636-646.
BACKGROUND: In atopic patients, allergen-specific T cells express the Th2 phenotype. It is known that interleukin-12 (IL-12) is a major cytokine for the induction of Th1 responses and that a...
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