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The Impact of Insulin Resistance on Hepatic Fibrosis among United States Adults with Non-Alcoholic Fatty Liver Disease: NHANES 2017 to 2018

Bae JC, Beste LA, Utzschneider KM

Background: We aimed to investigate the association of hepatic steatosis with liver fibrosis and to assess the interactive effects of hepatic steatosis and insulin resistance on liver fibrosis in a...
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Association between Relative Handgrip Strength and Insulin Resistance in Korean Elderly Men without Diabetes: Findings of the 2015 Korea National Health Nutrition Examination Survey

Joo KC, Son DH, Park JM

Background: Evidence regarding the association between handgrip strength (HGS) and insulin resistance in a non-diabetic population is scarce. This study aimed to investigate the association between relative HGS and insulin...
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Normalized Creatinine-to-Cystatin C Ratio and Risk of Diabetes in Middle-Aged and Older Adults: The China Health and Retirement Longitudinal Study

Qiu S, Cai X, Xie B, Yuan Y, Sun Z, Wu T

Background: Creatinine-to-cystatin C ratio is recently suggested to be a surrogate marker for sarcopenia. However, little is known about its association with diabetes. This study aimed to fill in this...
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Pathophysiological aspects of insulin resistance in Atrial Fibrillation: novel therapeutic approaches

Rafaqat S, Rafaqat S, Rafaqat S

Background: Insulin resistance is associated with metabolic disorders including diabetes, obesity, hypertension, and inflammation which are the risk factors for Atrial Fibrillation. Many studies have reported that type 2 diabetes...
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Iron Overload and the Risk of Diabetes in the General Population: Results of the Chinese Health and Nutrition Survey Cohort Study

Gao H, Yang J, Pan W, Yang M

Background: Recent studies have found that there are significant associations between body iron status and the development of diabetes. In the present study, we aimed to analyze the association among...
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Food Security Moderates the Relationships of Muscle Mass with Metabolic Syndrome and Insulin Resistance

Lee K

Background: This study aimed to determine whether food security moderates the relationship of skeletal muscle mass with metabolic syndrome (MetS) and insulin resistance (IR). Methods: This study analyzed the data of...
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The Impact of Psychological Insulin Resistance on Self-Care Activities in Patients with Type 2 Diabetes Mellitus Undergoing Insulin Therapy

Kim MG, Song HJ

Purpose: The purpose of this study was to identify the level of psychological insulin resistance and self-care activities and to evaluate the factors affecting self-care activities in patients with type...
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The protective effects of Aster yomena (Kitam.) Honda on high-fat diet-induced obese C57BL/6J mice

Kim MJ, Kim JH, Lee S, Kim B, Kim HY

BACKGROUND/OBJECTIVES: Aster yomena (Kitam.) Honda (AY) has remarkable bioactivities, such as antioxidant, anti-inflammation, and anti-cancer activities. On the other hand, the effects of AY against obesity-induced insulin resistance have not...
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Insulin Resistance: From Mechanisms to Therapeutic Strategies

Lee SH, Park SY, Choi CS

Insulin resistance is the pivotal pathogenic component of many metabolic diseases, including type 2 diabetes mellitus, and is defined as a state of reduced responsiveness of insulin-targeting tissues to physiological...
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Four-year changes in central fatness, risk of diabetes, and metabolic control in older adults: a cohort study with mediation analysis

Cai X, Luo D, Liu S, Li R, Lu Y, Li M, Qiu S

Background/Aims: Older adults are vulnerable to central obesity, while the association of changes in central fatness with risk of diabetes and metabolic control has not been investigated among this particular...
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Effect of obesity and metabolic health on urolithiasis: A nationwide population-based study

Choi C, Kim JK, Han K, Lee YG, Han JH

Purpose: To investigate the risk of symptomatic urolithiasis requiring surgical treatment according to obesity and metabolic health status using a nationwide dataset of the Korean population. Materials and Methods: Of the...
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Asthma Phenotype with Metabolic Dysfunction

Park JW

Asthma is chronic eosinophilic bronchitis with the dominancy of T helper 2 (Th2) inflammation. However, patients with asthma and metabolic dysfunction have pathogenic and pathological differences from those with Th2...
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Association between the serum estrone-to-estradiol ratio and parameters related to glucose metabolism and insulin resistance in women with polycystic ovary syndrome

Kim N, Chun S

Objective: We aimed to evaluate associations between the ratio of serum estrone (E1) to estradiol (E2) and parameters related to serum glucose metabolism and insulin resistance in women with polycystic...
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Obesity, Diabetes, and Increased Cancer Progression

Kim DS, Scherer PE

Rates of obesity and diabetes have increased significantly over the past decades and the prevalence is expected to continue to rise further in the coming years. Many observations suggest that...
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Carnitine Orotate Complex Ameliorates Insulin Resistance and Hepatic Steatosis Through Carnitine Acetyltransferase Pathway

Hong JH, Lee MK

Background: Carnitine orotate complex (Godex) has been shown to decrease glycated hemoglobin levels and improve steatosis in patients with type 2 diabetes mellitus with non-alcoholic fatty liver disease. However, the...
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Musclin Is Related to Insulin Resistance and Body Composition, but Not to Body Mass Index or Cardiorespiratory Capacity in Adults

Sánchez YL, Yepes-Calderón M, Valbuena L, Milán AF, Trillos-Almanza MC, Granados S, Peña M, Estrada-Castrillón M, Aristizábal JC, Narvez-Sanchez R, Gallo-Villegas J, Calderón JC

Background: We studied whether musclin function in humans is related to glycemic control, body composition, and cardiorespiratory capacity. Methods: A cross-sectional study was performed in sedentary adults with or without metabolic...
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Changes in Insulin Resistance Index and the Risk of Liver Fibrosis in Patients with Nonalcoholic Fatty Liver Disease without Diabetes: Kangbuk Samsung Health Study

Koo DJ, Lee MY, Jung I, Moon SJ, Kwon H, Park SE, Rhee EJ, Lee WY

Background: Fibrosis is the most important prognostic factor for nonalcoholic fatty liver disease (NAFLD). Insulin resistance plays a key role of fibrosis progression. We evaluated the association between changes in...
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Macrophage and Adipocyte Mitochondrial Dysfunction in Obesity-Induced Metabolic Diseases

Wang L, Hu J, Zhou H

Obesity is one of major health burdens of modern society as it contributes to the growing prevalence of its related comorbidities, such as diabetes, cardiovascular diseases, and some cancers. A...
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Combined Effects of Insulin Resistance and Inflammation on Comorbidities of Type 2 Diabetes

Kim EJ, Lee EY, Lee YH, Choi YJ, Park SW, Lee EJ, Lee HC, Huh KB

Background: Insulin resistance (IR) and inflammation are closely related to each other and share common pathophysiological and metabolic mechanisms. We aimed to investigate the combined effect of IR and inflammation...
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Unravelling Polycystic Ovary Syndrome and Its Comorbidities

Kim KW

Polycystic ovary syndrome (PCOS) is a chronic multisystem endocrine disorder that affects women of reproductive age. In the ovary, the dynamic balance between dormant and growing follicles that culminates in...
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